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Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs (2021)
Journal Article
Solagna, F., Tezze, C., Lindenmeyer, M. T., Lu, S., Wu, G., Liu, S., Zhao, Y., Mitchell, R., Meyer, C., Omairi, S., Kilic, T., Paolini, A., Ritvos, O., Pasternack, A., Matsakas, A., Kylies, D., zur Wiesch, J. S., Turner, J. E., Wanner, N., Nair, V., …Huber, T. B. (2021). Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs. Journal of Clinical Investigation, 131(11), Article e135821. https://doi.org/10.1172/JCI135821

Skeletal muscle wasting is commonly associated with chronic kidney disease (CKD), resulting in increased morbidity and mortality. However, the link between kidney and muscle function remains poorly understood. Here, we took a complementary interorgan... Read More about Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs.

Inertial focusing of microparticles, bacteria, and blood in serpentine glass channels (2021)
Journal Article
Rodriguez-Mateos, P., Ngamsom, B., Dyer, C. E., Iles, A., & Pamme, N. (in press). Inertial focusing of microparticles, bacteria, and blood in serpentine glass channels. ELECTROPHORESIS, https://doi.org/10.1002/elps.202100083

Early detection of pathogenic microorganisms is pivotal to diagnosis and prevention of health and safety crises. Standard methods for pathogen detection often rely on lengthy culturing procedures, confirmed by biochemical assays, leading to >24 h for... Read More about Inertial focusing of microparticles, bacteria, and blood in serpentine glass channels.

COSMIC, chemotherapy plus ofatumumab at standard or mega-dose in chronic lymphocytic leukaemia, a phase II randomised study (2021)
Journal Article
Allsup, D., Howard, D., Emmerson, J., Hockaday, A., Rawstron, A., Oughton, J. B., Bloor, A., Phillips, D., Nathwani, A., Paneesha, S., Turner, D., Munir, T., & Hillmen, P. (in press). COSMIC, chemotherapy plus ofatumumab at standard or mega-dose in chronic lymphocytic leukaemia, a phase II randomised study. British journal of haematology, https://doi.org/10.1111/bjh.17526

Intraovarian injection of platelet-rich plasma in assisted reproduction: too much too soon? (2021)
Journal Article
Atkinson, L., Martin, F., & Sturmey, R. G. (2021). Intraovarian injection of platelet-rich plasma in assisted reproduction: too much too soon?. Human Reproduction, 36(7), 1737-1750. https://doi.org/10.1093/humrep/deab106

The prospect of ovarian rejuvenation offers the tantalising prospect of treating age-related declines in fertility or in pathological conditions such as premature ovarian failure. The concept of ovarian rejuvenation was invigorated by the indication... Read More about Intraovarian injection of platelet-rich plasma in assisted reproduction: too much too soon?.

Ovarian Cancer in the Sudan - Identifying the Social and Clinical Factors that Prevent an Early Diagnosis (2021)
Journal Article
Mohamed, E., Bature, F., Ali, I., Abdelaziz, F., Alsayed, S., Mukhtar, M., Osman, B., & Guinn, B. (2021). Ovarian Cancer in the Sudan - Identifying the Social and Clinical Factors that Prevent an Early Diagnosis. Austin Journal of Obstetrics and Gynecology, 8(5), Article 1181. https://doi.org/10.26420/austiniobstetgynecol.2021.1181

Ovarian cancer, because it often presents with vague symptoms, is a difficult disease to diagnose at the early stages, especially in developing countries. In Sudan, diagnosis is further complicated by additional factors and challenges. First, as in a... Read More about Ovarian Cancer in the Sudan - Identifying the Social and Clinical Factors that Prevent an Early Diagnosis.

Biofilm-Infected Human Clusteroid Three-Dimensional Coculture Platform to Replace Animal Models in Testing Antimicrobial Nanotechnologies (2021)
Journal Article
Wang, A., Weldrick, P., Madden, L. A., & Paunov, V. N. (2021). Biofilm-Infected Human Clusteroid Three-Dimensional Coculture Platform to Replace Animal Models in Testing Antimicrobial Nanotechnologies. ACS Applied Materials & Interfaces, 13(19), 22182-22194. https://doi.org/10.1021/acsami.1c02679

Microbial biofilms are a major concern in wound care, implant devices, and organ infections. Biofilms allow higher tolerance to antimicrobial drugs, can impair wound healing, and potentially lead to sepsis. There has been a recent focus on developing... Read More about Biofilm-Infected Human Clusteroid Three-Dimensional Coculture Platform to Replace Animal Models in Testing Antimicrobial Nanotechnologies.

Investigation of the effects of anticoagulants on tissue factor mediated cellular processes (2021)
Thesis
Featherby, S. Investigation of the effects of anticoagulants on tissue factor mediated cellular processes. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4223521

Thrombotic complications are common in cancer patients and are amongst the leading causes of morbidity and mortality. Recently, it was reported that treatment of cancer patients with the low molecular weight heparin (LMWH) family of anticoagulants ca... Read More about Investigation of the effects of anticoagulants on tissue factor mediated cellular processes.

Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation (2021)
Journal Article
Englert, H., Rangaswamy, C., Deppermann, C., Sperhake, J. P., Krisp, C., Schreier, D., Gordon, E., Konrath, S., Haddad, M., Pula, G., Mailer, R. K., Schlüter, H., Kluge, S., Langer, F., Püschel, K., Panousis, K., Stavrou, E. X., Maas, C., Renné, T., & Frye, M. (2021). Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation. EBioMedicine, 67, Article 103382. https://doi.org/10.1016/j.ebiom.2021.103382

Background: Coagulopathy and inflammation are hallmarks of Coronavirus disease 2019 (COVID-19) and are associated with increased mortality. Clinical and experimental data have revealed a role for neutrophil extracellular traps (NETs) in COVID-19 dise... Read More about Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation.

Current and emerging investigational venetoclax-based therapies in chronic lymphocytic leukemia (2021)
Journal Article
Molica, S., Allsup, D., Gianfelici, V., Levato, L., Aiello, V., Bailey, J., & Polliack, A. (in press). Current and emerging investigational venetoclax-based therapies in chronic lymphocytic leukemia. Expert Opinion on Investigational Drugs, https://doi.org/10.1080/13543784.2021.1924669

Introduction: Venetoclax has emerged as a breakthrough treatment which has revolutionized the therapeutic paradigm of chronic lymphocytic leukemia (CLL). This is primarily attributed to the efficacy of venetoclax as a time-limited, chemo-free, therap... Read More about Current and emerging investigational venetoclax-based therapies in chronic lymphocytic leukemia.

Effect of treatment planning system parameters on beam modulation complexity for treatment plans with single-layer multi-leaf collimator and dual-layer stacked multi-leaf collimator (2021)
Journal Article
Quintero, P., Cheng, Y., Benoit, D., Moore, C., & Beavis, A. (2021). Effect of treatment planning system parameters on beam modulation complexity for treatment plans with single-layer multi-leaf collimator and dual-layer stacked multi-leaf collimator. British Journal of Radiology, 94(1122), Article 20201011. https://doi.org/10.1259/bjr.20201011

OBJECTIVE: High levels of beam modulation complexity (MC) and monitor units (MU) can compromise the plan deliverability of intensity-modulated radiotherapy treatments. Our study evaluates the effect of three treatment planning system (TPS) parameters... Read More about Effect of treatment planning system parameters on beam modulation complexity for treatment plans with single-layer multi-leaf collimator and dual-layer stacked multi-leaf collimator.

Immune Responses to Persistent or Recurrent Antigens: Implications for Immunological Memory and Immunotherapy (2021)
Book
Pera, A., & Caserta, S. (Eds.). (2021). Immune Responses to Persistent or Recurrent Antigens: Implications for Immunological Memory and Immunotherapy. Frontiers Media. https://doi.org/10.3389/978-2-88966-718-5

Immunological memory is considered the hallmark of the adaptive immune response, which is essential for long-term protection against infection throughout life. From the perspective of adaptive immunity, clonally expanded antigen-specific lymphocytes... Read More about Immune Responses to Persistent or Recurrent Antigens: Implications for Immunological Memory and Immunotherapy.

Radiolabelling an 18F biologic via facile IEDDA “click” chemistry on the GE FASTLab™ platform (2021)
Journal Article
Allott, L., Amgheib, A., Barnes, C., Braga, M., Brickute, D., Wang, N., Fu, R., Ghaem-Maghami, S., & Aboagye, E. O. (in press). Radiolabelling an 18F biologic via facile IEDDA “click” chemistry on the GE FASTLab™ platform. Reaction Chemistry and Engineering, https://doi.org/10.1039/d1re00117e

The use of biologics in positron emission tomography (PET) imaging is an important area of radiopharmaceutical development and new automated methods are required to facilitate their production. We report an automated radiosynthesis method to produce... Read More about Radiolabelling an 18F biologic via facile IEDDA “click” chemistry on the GE FASTLab™ platform.

Release of redox enzymes and micro-RNAs in extracellular vesicles, during infection and inflammation (2021)
Journal Article
Caserta, S., & Ghezzi, P. (2021). Release of redox enzymes and micro-RNAs in extracellular vesicles, during infection and inflammation. Free radical biology & medicine, 169, 248-257. https://doi.org/10.1016/j.freeradbiomed.2021.04.010

Many studies reported that redox enzymes, particularly thioredoxin and peroxiredoxin, can be released by cells and act as soluble mediators in immunity. Recently, it became clear that peroxiredoxins can be secreted via the exosome-release route, yet... Read More about Release of redox enzymes and micro-RNAs in extracellular vesicles, during infection and inflammation.

The effects of chlorination, thickness, and moisture on glove donning efficiency (2021)
Journal Article
Preece, D., Hong Ng, T., Tong, H. K., Lewis, R., & Carré, M. J. (2021). The effects of chlorination, thickness, and moisture on glove donning efficiency. Ergonomics, 64(9), 1205-1216. https://doi.org/10.1080/00140139.2021.1907452

Changing gloves more frequently is encouraged, more now than ever given the COVID-19 pandemic. When the donning process has moisture introduced, however, complications can arise, which consumes vital time. Most commonly, gloves undergo a chlorination... Read More about The effects of chlorination, thickness, and moisture on glove donning efficiency.

Embryo Metabolism and What Does the Embryo Need? (2021)
Book Chapter
Vergaro, P., & Sturmey, R. G. (2021). Embryo Metabolism and What Does the Embryo Need?. In K. Lundin, & A. Ahlström (Eds.), Manual of Embryo Culture in Human Assisted Reproduction (30-41). Cambridge University Press. https://doi.org/10.1017/9781108874014.005

The embryo is a dynamic structure that can be affected by the interaction with the surrounding environment. During its journey through the female reproductive tract from fertilization to implantation, the embryo undergoes numerous biochemical and phy... Read More about Embryo Metabolism and What Does the Embryo Need?.

Culture Media and Embryo Culture (2021)
Book Chapter
Sunde, A., & Sturmey, R. G. (2021). Culture Media and Embryo Culture. In K. Lundin, & A. Ahlström (Eds.), Manual of Embryo Culture in Human Assisted Reproduction (42-52). Cambridge University Press. https://doi.org/10.1017/9781108874014.006

Before considering the basis of embryo culture medium, it is worthwhile reflecting on its function. A detailed overview of embryo metabolism is given in Chapter 4; however, in brief, the embryo must satisfy changing demands for energy by consumption... Read More about Culture Media and Embryo Culture.

Investigating the role of arginine methylation in glioblastoma using biomicrofluidics (2021)
Thesis
Samuel, S. F. Investigating the role of arginine methylation in glioblastoma using biomicrofluidics. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4223865

Despite intense research, the prognosis of patients with glioblastoma (GBM) remains extremely poor, with a median survival of 1.5 years after diagnosis. The need for new therapeutic options is therefore a vital step towards securing a better outlook... Read More about Investigating the role of arginine methylation in glioblastoma using biomicrofluidics.

Cytomegalovirus infection is associated with an increase in aortic stiffness in older men which may be mediated in part by CD4 memory T-cells (2021)
Journal Article
Kirkham, F., Pera, A., Simanek, A. M., Bano, A., Morrow, G., Reus, B., Caserta, S., Smith, H. E., Davies, K. A., Rajkumar, C., & Kern, F. (in press). Cytomegalovirus infection is associated with an increase in aortic stiffness in older men which may be mediated in part by CD4 memory T-cells. Theranostics, 11(12), 5728-5741. https://doi.org/10.7150/thno.58356

Human Cytomegalovirus (CMV) infection is associated with atherosclerosis, higher cardiovascular disease (CVD) risk, and an increase in memory T-cells (Tmem). T-cells have also been implicated in CVD, independently of CMV infection. To better understa... Read More about Cytomegalovirus infection is associated with an increase in aortic stiffness in older men which may be mediated in part by CD4 memory T-cells.

Investigating oxygen transport efficiencies in precision-cut liver slice-based organ-on-a-chip devices (2021)
Journal Article
Christensen, M. G., Cawthorne, C., Dyer, C. E., Greenman, J., & Pamme, N. (2021). Investigating oxygen transport efficiencies in precision-cut liver slice-based organ-on-a-chip devices. Microfluidics and Nanofluidics, 25(4), Article 35. https://doi.org/10.1007/s10404-021-02434-x

Microfluidic ‘organ-on-a-chip’ devices hold great potential for better mimicking the continuous flow microenvironment experienced by tissue and cells in vivo, thereby ensuring realistic transport of nutrients and elimination of waste products. Howeve... Read More about Investigating oxygen transport efficiencies in precision-cut liver slice-based organ-on-a-chip devices.