All Outputs (69)

Accuracy and utility of blood and urine biomarkers for the noninvasive diagnosis of endometriosis: a systematic literature review and meta-analysis (2022)
Journal Article
Dolińska, W., Draper, H., Othman, L., Thompson, C., Girvan, S., Cunningham, K., Allen, J., Rigby, A., Phillips, K., & Guinn, B. A. (2023). Accuracy and utility of blood and urine biomarkers for the noninvasive diagnosis of endometriosis: a systematic literature review and meta-analysis. F&S Reviews, 4(2), 116-130. https://doi.org/10.1016/j.xfnr.2022.12.001

Objective: Endometriosis is a chronic, incurable condition associated with debilitating pain and subfertility affecting over 190 million women worldwide, which has no reliable noninvasive diagnostic tool. We aimed to determine the state-of-the-art in... Read More about Accuracy and utility of blood and urine biomarkers for the noninvasive diagnosis of endometriosis: a systematic literature review and meta-analysis.

Chronic cough—the limitation and advances in assessment techniques (2022)
Journal Article
Zhang, M., Sykes, D. L., Brindle, K., Sadofsky, L. R., & Morice, A. H. (2022). Chronic cough—the limitation and advances in assessment techniques. Journal of thoracic disease, 14(12), 5097-5119. https://doi.org/10.21037/jtd-22-874

Accurate and consistent assessments of cough are essential to advance the understanding of the mechanisms of cough and individualised the management of patients. Considerable progress has been made in this work. Here we reviewed the currently availab... Read More about Chronic cough—the limitation and advances in assessment techniques.

Machine learning-based predictions of gamma passing rates for virtual specific-plan verification based on modulation maps, monitor unit profiles, and composite dose images (2022)
Journal Article
Quintero, P., Benoit, D., Cheng, Y., Moore, C., & Beavis, A. (2022). Machine learning-based predictions of gamma passing rates for virtual specific-plan verification based on modulation maps, monitor unit profiles, and composite dose images. Physics in Medicine and Biology, 67(24), Article 245001. https://doi.org/10.1088/1361-6560/aca38a

Machine learning (ML) methods have been implemented in radiotherapy to aid virtual specific-plan verification protocols, predicting gamma passing rates (GPR) based on calculated modulation complexity metrics because of their direct relation to dose d... Read More about Machine learning-based predictions of gamma passing rates for virtual specific-plan verification based on modulation maps, monitor unit profiles, and composite dose images.

Investigating the importance of CBX2’s structural motifs for its chromatin interactions and pro-oncogenic epigenetic regulatory function in triple negative breast cancer (2022)
Thesis
Dobrowinski, W. Investigating the importance of CBX2’s structural motifs for its chromatin interactions and pro-oncogenic epigenetic regulatory function in triple negative breast cancer. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4291232

Epigenetics is the study of the change in gene expression patterns that are not caused by direct alterations in the DNA nucleotide sequence but instead are as a result of the dynamic remodelling of the chromatin state. Regulation of the chromatin lan... Read More about Investigating the importance of CBX2’s structural motifs for its chromatin interactions and pro-oncogenic epigenetic regulatory function in triple negative breast cancer.

The language of abiotic stress in aquatic animals : molecular characterisation of stress metabolite-mediated stress communication (2022)
Thesis
Feugère, L. The language of abiotic stress in aquatic animals : molecular characterisation of stress metabolite-mediated stress communication. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4311814

It is well established that aquatic animals inform their neighbours of predation risk through chemical cues. In this thesis, I tested the hypothesis that stress propagation is a widespread mechanism also activated by abiotic stressors – such as those... Read More about The language of abiotic stress in aquatic animals : molecular characterisation of stress metabolite-mediated stress communication.

Outdoor Microplastic Analysis Using Inlet Filters from an NOx Regulatory Air Quality Monitoring Device (2022)
Journal Article
Jenner, L. C., Kureshi, R. R., White, D., Chapman, E., Sadofsky, L. R., & Rotchell, J. M. (2022). Outdoor Microplastic Analysis Using Inlet Filters from an NOx Regulatory Air Quality Monitoring Device. Atmosphere, 13(12), Article 2017. https://doi.org/10.3390/atmos13122017

Atmospheric microplastics (MPs) are a ubiquitous environmental contaminant of emerging concern. Sampling methods provide information relating to surface area concentration and MP characteristics, without direct comparison with routinely measured stan... Read More about Outdoor Microplastic Analysis Using Inlet Filters from an NOx Regulatory Air Quality Monitoring Device.

Investigating the role Of CBX2 to promote cell growth in triple negative breast cancer (2022)
Thesis
Bilton, L. Investigating the role Of CBX2 to promote cell growth in triple negative breast cancer. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4240594

Breast cancer is the uncontrolled proliferation of breast cells and is one of the most common cancers in the UK. It is a complex disease that can be divided into different subtypes based upon the presence or lack of hormone receptors, namely the oest... Read More about Investigating the role Of CBX2 to promote cell growth in triple negative breast cancer.

Investigating the impact of interstitial fluid flow on cancer biology (2022)
Thesis
Pyne, E. S. Investigating the impact of interstitial fluid flow on cancer biology. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4251436

Despite major advances in our understanding of cancer progression mechanisms, cancer remains a leading cause of death in the UK and globally. Solid tumours are complex, and heterogeneous, existing in a dynamic microenvironment subjected to a variety... Read More about Investigating the impact of interstitial fluid flow on cancer biology.

Airborne transmission of biological agents within the indoor built environment: a multidisciplinary review (2022)
Journal Article
Argyropoulos, C. D., Skoulou, V., Efthimiou, G., & Michopoulos, A. K. (2022). Airborne transmission of biological agents within the indoor built environment: a multidisciplinary review. Air Quality, Atmosphere and Health, https://doi.org/10.1007/s11869-022-01286-w

The nature and airborne dispersion of the underestimated biological agents, monitoring, analysis and transmission among the human occupants into building environment is a major challenge of today. Those agents play a crucial role in ensuring comforta... Read More about Airborne transmission of biological agents within the indoor built environment: a multidisciplinary review.

Microplastics in the surgical environment (2022)
Journal Article
Field, D. T., Green, J. L., Bennett, R., Jenner, L. C., Sadofsky, L., Chapman, E., Loubani, M., & Rotchell, J. M. (2022). Microplastics in the surgical environment. Environment International, 170, Article 107630. https://doi.org/10.1016/j.envint.2022.107630

Atmospheric microplastics (MPs) have been consistently detected within indoor and outdoor air samples. Locations with high human activity are reported to have high MP levels. The aim was to quantify and characterise the MPs present within the surgica... Read More about Microplastics in the surgical environment.

A sample-to-answer COVID-19 diagnostic device based on immiscible filtration and CRISPR-Cas12a-assisted detection (2022)
Journal Article
Ngamsom, B., Iles, A., Kamita, M., Kimani, R., Wakaba, P., Rodriguez-Mateos, P., Mungai, M., Dyer, C. E., Walter, C., Gitaka, J., & Pamme, N. (2022). A sample-to-answer COVID-19 diagnostic device based on immiscible filtration and CRISPR-Cas12a-assisted detection. Talanta Open, 6, Article 100166. https://doi.org/10.1016/j.talo.2022.100166

In response to the ongoing coronavirus disease 2019 (COVID-19) pandemic and disparities of vaccination coverage in low-and middle-income countries, it is vital to adopt a widespread testing and screening programme, combined with contact tracing, to m... Read More about A sample-to-answer COVID-19 diagnostic device based on immiscible filtration and CRISPR-Cas12a-assisted detection.

Insights into the Effect of Magnetic Confinement on the Performance of Magnetic Nanocomposites in Magnetic Hyperthermia and Magnetic Resonance Imaging (2022)
Journal Article
Scialla, S., Genicio, N., Brito, B., Florek-Wojciechowska, M., Stasiuk, G. J., Kruk, D., Bañobre-López, M., & Gallo, J. (2022). Insights into the Effect of Magnetic Confinement on the Performance of Magnetic Nanocomposites in Magnetic Hyperthermia and Magnetic Resonance Imaging. ACS Applied Nano Materials, 5(11), 16462–16474. https://doi.org/10.1021/acsanm.2c03537

The combination of superparamagnetic iron oxide nanoparticles (SPIONs) and lipid matrices enables the integration of imaging, drug delivery, and therapy functionalities into smart theranostic nanocomposites. SPION confinement creates new interactions... Read More about Insights into the Effect of Magnetic Confinement on the Performance of Magnetic Nanocomposites in Magnetic Hyperthermia and Magnetic Resonance Imaging.

Identification and prioritization of tumour-associated antigens for immunotherapeutic and diagnostic capacity in epithelial ovarian cancer: a systematic literature review (2022)
Journal Article
Wiseman, L., Cinti, N., & Guinn, B. A. (2022). Identification and prioritization of tumour-associated antigens for immunotherapeutic and diagnostic capacity in epithelial ovarian cancer: a systematic literature review. Carcinogenesis, 43(11), 1015-1029. https://doi.org/10.1093/carcin/bgac084

Epithelial ovarian cancer (EOC) is a prevalent carcinoma in the female population associated with poor prognostic outcomes, in part due to the late stage of the disease at diagnosis. Aiming to identify tumour-associated antigens (TAAs) with the poten... Read More about Identification and prioritization of tumour-associated antigens for immunotherapeutic and diagnostic capacity in epithelial ovarian cancer: a systematic literature review.

Age-Associated Changes in Voltage-Gated Sodium Channels Within the Right Atrium Predispose the Elderly to Atrial Fibrillation (2022)
Thesis
Isaac, E. S. Age-Associated Changes in Voltage-Gated Sodium Channels Within the Right Atrium Predispose the Elderly to Atrial Fibrillation. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4508137

Atrial Fibrillation (AF) is the most common cardiac arrhythmia worldwide with sufferers of the condition facing significant morbidity and mortality. Ageing alone is identified as the most significant risk factor for developing the arrhythmia. As such... Read More about Age-Associated Changes in Voltage-Gated Sodium Channels Within the Right Atrium Predispose the Elderly to Atrial Fibrillation.

Should aspirin be replaced with ADP blockers or anti-GPVI to manage thrombosis? (2022)
Journal Article
Khan, H., Ghulam, T., Ahmed, N., Babar, M. R., Calaminus, S. D., & Yusuf, M. Z. (2022). Should aspirin be replaced with ADP blockers or anti-GPVI to manage thrombosis?. Vascular Biology, https://doi.org/10.1530/vb-22-0010

Platelets have a pivotal role in maintaining cardiovascular homeostasis. They are kept docile by endothelial derived mediators. Aberration in haemostatic balance predisposes an individual to an elevated risk of a pro-thrombotic environment. Anti-plat... Read More about Should aspirin be replaced with ADP blockers or anti-GPVI to manage thrombosis?.

Computational Studies on Selected Macrolides Active against Escherichia coli Combined with the NMR Study of Tylosin A in Deuterated Chloroform (2022)
Journal Article
Arsic, B., Barber, J., Cikos, A., Kadirvel, M., Kostic, E., McBain, A., Milicevic, J., Oates, A., & Regan, A. (2022). Computational Studies on Selected Macrolides Active against Escherichia coli Combined with the NMR Study of Tylosin A in Deuterated Chloroform. Molecules, 27(21), Article 7280. https://doi.org/10.3390/molecules27217280

Although many antibiotics are active against Gram-positive bacteria, fewer also show activity against Gram-negative bacteria. Here, we present a combination of in silico (electron ion-interaction potential, molecular docking, ADMET), NMR, and microbi... Read More about Computational Studies on Selected Macrolides Active against Escherichia coli Combined with the NMR Study of Tylosin A in Deuterated Chloroform.

Cancer patients’ experiences of the diagnosis and treatment of incidental pulmonary embolism (a qualitative study) (2022)
Journal Article
Benelhaj, N. E., Hutchinson, A., Maraveyas, A., & Johnson, M. (2022). Cancer patients’ experiences of the diagnosis and treatment of incidental pulmonary embolism (a qualitative study). PLoS ONE, 17(10), Article e0276754. https://doi.org/10.1371/journal.pone.0276754

Background: The diagnosis of symptomatic cancer-associated thrombosis often causes distress and alarm for patients, especially for those unaware of the risk, or the signs and symptoms to look out for. There are few data about cancer patients’ experie... Read More about Cancer patients’ experiences of the diagnosis and treatment of incidental pulmonary embolism (a qualitative study).

Bn2DT3A, a Chelator for 68Ga Positron Emission Tomography: Hydroxide Coordination Increases Biological Stability of [68Ga][Ga(Bn2DT3A)(OH)]− (2022)
Journal Article
Price, T. W., Renard, I., Prior, T. J., Kubíček, V., Benoit, D. M., Archibald, S. J., Seymour, A. M., Hermann, P., & Stasiuk, G. J. (2022). Bn2DT3A, a Chelator for 68Ga Positron Emission Tomography: Hydroxide Coordination Increases Biological Stability of [68Ga][Ga(Bn2DT3A)(OH)]−. Inorganic chemistry, 61(43), 17059–17067. https://doi.org/10.1021/acs.inorgchem.2c01992

The chelator Bn2DT3A was used to produce a novel 68Ga complex for positron emission tomography (PET). Unusually, this system is stabilized by a coordinated hydroxide in aqueous solutions above pH 5, which confers sufficient stability for it to be use... Read More about Bn2DT3A, a Chelator for 68Ga Positron Emission Tomography: Hydroxide Coordination Increases Biological Stability of [68Ga][Ga(Bn2DT3A)(OH)]−.

Studies on skeletal muscle stem cell biology of the apolipoprotein E deficient mice (2022)
Thesis
Barlow, J. J. Studies on skeletal muscle stem cell biology of the apolipoprotein E deficient mice. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4224384

Skeletal muscle has tremendous adaptive and regenerative ability, this is achieved through a resource of stem cells which remain present in adults. These cells remain quiescent until activated by myogenic factors, at which point they proliferate and... Read More about Studies on skeletal muscle stem cell biology of the apolipoprotein E deficient mice.

Corrigendum: MEF2 transcription factors are key regulators of sprouting angiogenesis (2022)
Journal Article
Sacilotto, N., Chouliaras, K. M., Nikitenko, L. L., Lu, Y. W., Fritzsche, M., Wallace, M. D., Nornes, S., García-Moreno, F., Payne, S., Bridges, E., Liu, K., Biggs, D., Ratnayaka, I., Herbert, S. P., Molnár, Z., Harris, A. L., Davies, B., Bond, G. L., Bou-Gharios, G., Schwarz, J. J., & De Val, S. (2022). Corrigendum: MEF2 transcription factors are key regulators of sprouting angiogenesis. Genes & development, 36(19-20), 1096. https://doi.org/10.1101/gad.350249.122

The above-mentioned article contained three errors in the Supplemental Figures. In Supplemental Figure 3D, both bar graphs are missing labels for the X-axes due to an oversight during figure preparation.