All Outputs (953)

Polyfunctionalised nanoparticles bearing robust gadolinium surface units for high relaxivity performance in MRI (2019)
Journal Article
Nicolas, C., Wenzel, M., Perry, H., Yoon, I.-C., Molisso, S., Stasiuk, G., Elson, D., Cass, A., & Wilton-Ely, J. (in press). Polyfunctionalised nanoparticles bearing robust gadolinium surface units for high relaxivity performance in MRI. Chemistry: a European journal, https://doi.org/10.1002/chem.201901820

The first example of an octadentate gadolinium unit based on DO3A (hydration number q = 1) with a dithiocarbamate tether has been designed and attached to the surface of gold nanoparticles (around 4.4 nm in diameter). In addition to the superior robu... Read More about Polyfunctionalised nanoparticles bearing robust gadolinium surface units for high relaxivity performance in MRI.

Breathing new life into old antibiotics: Overcoming antibacterial resistance by antibiotic-loaded nanogel carriers with cationic surface functionality (2019)
Journal Article
Weldrick, P. J., Iveson, S., Hardman, M. J., & Paunov, V. N. (2019). Breathing new life into old antibiotics: Overcoming antibacterial resistance by antibiotic-loaded nanogel carriers with cationic surface functionality. Nanoscale, 11(21), 10472-10485. https://doi.org/10.1039/c8nr10022e

Multidrug-resistant pathogens are prevalent in chronic wounds. There is an urgent need to develop novel antimicrobials and formulation strategies that can overcome antibiotic resistance and provide a safe alternative to traditional antibiotics. This... Read More about Breathing new life into old antibiotics: Overcoming antibacterial resistance by antibiotic-loaded nanogel carriers with cationic surface functionality.

Epigenetic Control of Gene Expression in the Normal and Malignant Human Prostate: A Rapid Response Which Promotes Therapeutic Resistance (2019)
Journal Article
Frame, F. M., & Maitland, N. J. (2019). Epigenetic Control of Gene Expression in the Normal and Malignant Human Prostate: A Rapid Response Which Promotes Therapeutic Resistance. International Journal of Molecular Sciences, 20(10), Article 2437. https://doi.org/10.3390/ijms20102437

A successful prostate cancer must be capable of changing its phenotype in response to a variety of microenvironmental influences, such as adaptation to treatment or successful proliferation at a particular metastatic site. New cell phenotypes emerge... Read More about Epigenetic Control of Gene Expression in the Normal and Malignant Human Prostate: A Rapid Response Which Promotes Therapeutic Resistance.

Application of extracellular flux analysis for determining mitochondrial function in mammalian oocytes and early embryos (2019)
Preprint / Working Paper
Muller, B., Lewis, N., Adeniyi, T., Leese, H. J., Brison, D., & Sturmey, R. G. Application of extracellular flux analysis for determining mitochondrial function in mammalian oocytes and early embryos

Background Mitochondria provide the major source of ATP for mammalian oocyte maturation and early embryo development. Oxygen Consumption Rate (OCR) is an established measure of mitochondrial function. OCR by mammalian oocytes and embryos has generall... Read More about Application of extracellular flux analysis for determining mitochondrial function in mammalian oocytes and early embryos.

Bioimprint aided cell recognition and depletion of human leukemic HL60 cells from peripheral blood (2019)
Journal Article
Das, A. A., Medlock, J., Liang, H., Nees, D., Allsup, D. J., Madden, L. A., & Paunov, V. N. (2019). Bioimprint aided cell recognition and depletion of human leukemic HL60 cells from peripheral blood. Journal of Materials Chemistry B, 7(22), 3497-3504. https://doi.org/10.1039/c9tb00679f

We report a large scale preparation of bioimprints of layers of cultured human leukemic HL60 cells which can perform cell shape and size recognition from a mixture with peripheral blood mononuclear cells (PBMCs). We demonstrate that the bioimprint-ce... Read More about Bioimprint aided cell recognition and depletion of human leukemic HL60 cells from peripheral blood.

The Ratio of Factor VIIa:Tissue Factor Content within Microvesicles Determines the Differential Influence on Endothelial Cells (2019)
Journal Article
Madkhali, Y., Featherby, S., Collier, M., Maraveyas, A., Greenman, J., & Ettelaie, C. (2019). The Ratio of Factor VIIa:Tissue Factor Content within Microvesicles Determines the Differential Influence on Endothelial Cells. TH Open, 03(02), e132-e145. https://doi.org/10.1055/s-0039-1688934

Tissue factor (TF)-positive microvesicles from various sources can promote cellular proliferation or alternatively induce apoptosis, but the determining factors are unknown. In this study the hypothesis that the ratio of fVIIa:TF within microvesicles... Read More about The Ratio of Factor VIIa:Tissue Factor Content within Microvesicles Determines the Differential Influence on Endothelial Cells.

Gene expression and metabolic response of bovine oviduct epithelial cells to the early embryo (2019)
Journal Article
Hamdi, M., Sánchez-Calabuig, M. J., Rodríguez-Alonso, B., Bagés-Arnal, S., Roussi, K., Sturmey, R., Gutiérrez-Adán, A., Lonergan, P., & Rizos, D. (2019). Gene expression and metabolic response of bovine oviduct epithelial cells to the early embryo. Reproduction, 158(1), 85-94. https://doi.org/10.1530/REP-18-0561

© 2019 Society for Reproduction and Fertility During its journey through the oviduct, the bovine embryo may induce transcriptomic and metabolic responses, via direct or indirect contact, from bovine oviduct epithelial cells (BOECs). An in vitro model... Read More about Gene expression and metabolic response of bovine oviduct epithelial cells to the early embryo.

Current Insights into the Potential Misuse of Platelet-based Applications for Doping in Sports (2019)
Journal Article
Scully, D., & Matsakas, A. (2019). Current Insights into the Potential Misuse of Platelet-based Applications for Doping in Sports. International journal of sports medicine, 40(7), 427-433. https://doi.org/10.1055/a-0884-0734

Platelet-based applications are currently used for the delivery of growth factors and other biomolecules as autologous biomaterials in regenerative medicine and cosmetic therapies. Many studies have revealed that platelet-based applications such as p... Read More about Current Insights into the Potential Misuse of Platelet-based Applications for Doping in Sports.

A patient tumour-on-a-chip system for personalised investigation of radiotherapy based treatment regimens (2019)
Journal Article
Kennedy, R., Kuvshinov, D., Sdrolia, A., Kuvshinova, E., Hilton, K., Crank, S., Beavis, A. W., Green, V., & Greenman, J. (2019). A patient tumour-on-a-chip system for personalised investigation of radiotherapy based treatment regimens. Scientific reports, 9(1), Article 6327. https://doi.org/10.1038/s41598-019-42745-2

Development of personalised cancer models to predict response to radiation would benefit patient care; particularly in malignancies where treatment resistance is prevalent. Herein, a robust, easy to use, tumour-on-a-chip platform which maintains prec... Read More about A patient tumour-on-a-chip system for personalised investigation of radiotherapy based treatment regimens.

Low molecular weight heparin and direct oral anticoagulants influence tumour formation, growth, invasion and vascularisation by separate mechanisms (2019)
Journal Article
Featherby, S., Xiao, Y. P., Ettelaie, C., Nikitenko, L. L., Greenman, J., & Maraveyas, A. (2019). Low molecular weight heparin and direct oral anticoagulants influence tumour formation, growth, invasion and vascularisation by separate mechanisms. Scientific reports, 9(1), Article 6272. https://doi.org/10.1038/s41598-019-42738-1

The bidirectional association between coagulation and cancer has been established. However, anticoagulant therapies have been reported to have beneficial outcomes by influencing the vascularisation of the tumours. In this study the influence of a set... Read More about Low molecular weight heparin and direct oral anticoagulants influence tumour formation, growth, invasion and vascularisation by separate mechanisms.

An analysis of the quality of experimental design and reliability of results in tribology research (2019)
Journal Article
Watson, M., Christoforou, P., Herrera, P., Preece, D., Carrell, J., Harmon, M., …Marshall, M. (2019). An analysis of the quality of experimental design and reliability of results in tribology research. Wear, 426-427, 1712-1718. https://doi.org/10.1016/j.wear.2018.12.028

In recent years several high profile projects have questioned the repeatability and validity of scientific research in the fields of psychology and medicine. In general, these studies have shown or estimated that less than 50% of published research f... Read More about An analysis of the quality of experimental design and reliability of results in tribology research.

The investigation of lipoxygenases as therapeutic targets in malignant pleural mesothelioma (2019)
Journal Article
Oguh-Olayinka, L., Agarwal, V., Ranatunge, D., Campbell, A., Laufer, S., Cawkwell, L., & Lind, M. J. (2020). The investigation of lipoxygenases as therapeutic targets in malignant pleural mesothelioma. Pathology and Oncology Research, 26(2), 985-995. https://doi.org/10.1007/s12253-019-00652-x

Advanced malignant pleural mesothelioma (MPM) has an extremely poor prognosis with limited chemotherapy options, therefore the identification of new therapeutic targets would aid in disease management. Arachidonic acid is metabolised by cyclooxygenas... Read More about The investigation of lipoxygenases as therapeutic targets in malignant pleural mesothelioma.

Circulating endothelial microparticles reduce in concentration following an exercise programme in women with polycystic ovary syndrome (2019)
Journal Article
Kirk, R. J., Madden, L. A., Peart, D. J., Aye, M. M., Atkin, S. L., & Vince, R. V. (2019). Circulating endothelial microparticles reduce in concentration following an exercise programme in women with polycystic ovary syndrome. Frontiers in endocrinology, 10(MAR), Article 200. https://doi.org/10.3389/fendo.2019.00200

Purpose: Endothelial dysfunction is a known comorbidity in women with polycystic ovary syndrome (PCOS). The aim was to assess if supervised, moderate intensity exercise could potentially impact markers of endothelial disruption; endothelial cell deri... Read More about Circulating endothelial microparticles reduce in concentration following an exercise programme in women with polycystic ovary syndrome.

Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling (2019)
Journal Article
Alyodawi, K., Vermeij, W., Omairi, S., Kretz, O., Hopkinson, M., Solagna, F., Joch, B., Brandt, R., Barnhoorn, S., Van Vliet, N., Ridwan, Y., Essers, J., Mitchell, R., Morash, T., Pasternack, A., Ritvos, O., Matsakas, A., Collins-Hooper, H., Huber, T., Hoeijmakers, J., & Patel, K. (2019). Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling. Journal of Cachexia, Sarcopenia and Muscle, 10(3), 662-686. https://doi.org/10.1002/jcsm.12404

© 2019 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders Background: One of the principles underpinning our understanding of ageing is t... Read More about Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling.

A novel microfluidic device capable of maintaining functional thyroid carcinoma specimens ex vivo provides a new drug screening platform (2019)
Journal Article
Riley, A., Green, V., Cheah, R., McKenzie, G., Karsai, L., England, J., & Greenman, J. (2019). A novel microfluidic device capable of maintaining functional thyroid carcinoma specimens ex vivo provides a new drug screening platform. BMC Cancer, 19(1), Article 259. https://doi.org/10.1186/s12885-019-5465-z

Background
Though the management of malignancies has improved vastly in recent years, many treatment options lack the desired efficacy and fail to adequately augment patient morbidity and mortality. It is increasingly clear that patient response to... Read More about A novel microfluidic device capable of maintaining functional thyroid carcinoma specimens ex vivo provides a new drug screening platform.

Synthesis of super bright indium phosphide colloidal quantum dots through thermal diffusion (2019)
Journal Article
Clarke, M. T., Viscomi, F. N., Chamberlain, T. W., Hondow, N., Adawi, A. M., Sturge, J., Erwin, S. C., Bouillard, J. S. G., Tamang, S., & Stasiuk, G. J. (2019). Synthesis of super bright indium phosphide colloidal quantum dots through thermal diffusion. Communications Chemistry, 2(1), Article 36. https://doi.org/10.1038/s42004-019-0138-z

© 2019, The Author(s). Indium phosphide based quantum dots have emerged in recent years as alternatives to traditional heavy metal (cadmium, lead) based materials suitable for biomedical application due to their non-toxic nature. The major barrier to... Read More about Synthesis of super bright indium phosphide colloidal quantum dots through thermal diffusion.

The enigmatic morula: mechanisms of development, cell fate determination, self-correction and implications for ART (2019)
Journal Article
Lagalla, C., Coticchio, G., Lagalla, C., Sturmey, R., Pennetta, F., & Borini, A. (2019). The enigmatic morula: mechanisms of development, cell fate determination, self-correction and implications for ART. Human Reproduction Update, 25(4), 422-438. https://doi.org/10.1093/humupd/dmz008

Background: Assisted reproduction technology offers the opportunity to observe the very early stages of human development. However, due to practical constraints, for decades morphological examination of embryo development has been undertaken at a few... Read More about The enigmatic morula: mechanisms of development, cell fate determination, self-correction and implications for ART.

N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites (2019)
Journal Article
Chandrabalan, A., McPhillie, M. J., Morice, A. H., Boa, A. N., & Sadofsky, L. R. (2019). N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites. European Journal of Medicinal Chemistry, 170, 141-156. https://doi.org/10.1016/j.ejmech.2019.02.074

The transient receptor potential ankyrin 1 (TRPA1) channel is a non-selective cation channel, which detects noxious stimuli leading to pain, itch and cough. However, the mechanism(s) of channel modulation by many of the known, non-reactive modulators... Read More about N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites.

Effects on prostate cancer cells of targeting RNA polymerase III (2019)
Journal Article
Petrie, J. L., Swan, C., Ingram, R. M., Frame, F. M., Collins, A. T., Dumay-Odelot, H., Teichmann, M., Maitland, N. J., & White, R. J. (2019). Effects on prostate cancer cells of targeting RNA polymerase III. Nucleic Acids Research, 47(8), 3937-3956. https://doi.org/10.1093/nar/gkz128

RNA polymerase (pol) III occurs in two forms, containing either the POLR3G subunit or the related paralogue POLR3GL. Whereas POLR3GL is ubiquitous, POLR3G is enriched in undifferentiated cells. Depletion of POLR3G selectively triggers proliferative a... Read More about Effects on prostate cancer cells of targeting RNA polymerase III.

Safety and efficacy of a sirolimus-eluting coronary stent with ultra-thin strut for treatment of atherosclerotic lesions (TALENT): a prospective multicentre randomised controlled trial (2019)
Journal Article
Zaman, A., de Winter, R. J., Kogame, N., Chang, C. C., Modolo, R., Spitzer, E., Tonino, P., Hofma, S., Zurakowski, A., Smits, P. C., Prokopczuk, J., Moreno, R., Choudhury, A., Petrov, I., Cequier, A., Kukreja, N., Hoye, A., Iniguez, A., Ungi, I., Serra, A., …Serruys, P. W. (2019). Safety and efficacy of a sirolimus-eluting coronary stent with ultra-thin strut for treatment of atherosclerotic lesions (TALENT): a prospective multicentre randomised controlled trial. Lancet, 393(10175), 987-997. https://doi.org/10.1016/S0140-6736%2818%2932467-X

Background: Supraflex is a sirolimus-eluting stent with a biodegradable polymer coating and ultra-thin struts. We aimed to compare Supraflex with the standard of care, Xience, an everolimus-eluting stent with a durable polymer coating, regarding clin... Read More about Safety and efficacy of a sirolimus-eluting coronary stent with ultra-thin strut for treatment of atherosclerotic lesions (TALENT): a prospective multicentre randomised controlled trial.