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Polyfunctionalised nanoparticles bearing robust gadolinium surface units for high relaxivity performance in MRI

Nicolas, Chabloz; Wenzel, Margot; Perry, Hannah; Yoon, Il-Chul; Molisso, Susannah; Stasiuk, Graeme; Elson, Daniel; Cass, Anthony; Wilton-Ely, James

Authors

Chabloz Nicolas

Margot Wenzel

Hannah Perry

Il-Chul Yoon

Susannah Molisso

Graeme Stasiuk

Daniel Elson

Anthony Cass

James Wilton-Ely



Abstract

The first example of an octadentate gadolinium unit based on DO3A (hydration number q = 1) with a dithiocarbamate tether has been designed and attached to the surface of gold nanoparticles (around 4.4 nm in diameter). In addition to the superior robustness of this attachment, the restricted rotation of the Gd complex on the nanoparticle surface leads to a dramatic increase in relaxivity (r1) from 4.0 mM‐1 s‐1 in unbound form to 34.3 mM‐1 s‐1 (at 10 MHz, 37 °C) and 22 ± 2 mM‐1s‐1 (at 63.87 MHz, 25 °C) when immobilised on the surface. The ‘one‐pot’ synthetic route provides a straightforward and versatile way of preparing a range of multifunctional gold nanoparticles. The incorporation of additional surface units improving biocompatibility (PEG and thioglucose units) and targeting (folic acid) lead to little detrimental effect on the high relaxivity observed for these non‐toxic multifunctional materials. In addition to the passive targeting attributed to gold nanoparticles, the inclusion of a unit capable of targeting the folate receptors overexpressed by cancer cells, such as HeLa cells, illustrates the potential of these assemblies.

Citation

Nicolas, C., Wenzel, M., Perry, H., Yoon, I., Molisso, S., Stasiuk, G., …Wilton-Ely, J. (in press). Polyfunctionalised nanoparticles bearing robust gadolinium surface units for high relaxivity performance in MRI. Chemistry : a European journal, https://doi.org/10.1002/chem.201901820

Journal Article Type Article
Acceptance Date May 22, 2019
Online Publication Date May 24, 2019
Deposit Date May 28, 2019
Publicly Available Date May 25, 2020
Journal Chemistry – A European Journal
Print ISSN 0947-6539
Electronic ISSN 1521-3765
Publisher Wiley
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1002/chem.201901820
Keywords General Chemistry
Public URL https://hull-repository.worktribe.com/output/1856587
Publisher URL https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201901820

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