Circulating endothelial microparticles reduce in concentration following an exercise programme in women with polycystic ovary syndrome

Kirk, Richard J.; Madden, Leigh A.; Peart, Daniel J.; Aye, Myint M.; Atkin, Stephen L.; Vince, Rebecca V.

doi:10.3389/fendo.2019.00200

Circulating endothelial microparticles reduce in concentration following an exercise programme in women with polycystic ovary syndrome

Kirk, Richard J.; Madden, Leigh A.; Peart, Daniel J.; Aye, Myint M.; Atkin, Stephen L.; Vince, Rebecca V.

Authors

Richard J. Kirk

Dr Leigh Madden L.A.Madden@hull.ac.uk
Post-Doctoral Research Assistant

Daniel J. Peart

Myint M. Aye

Stephen L. Atkin

Dr Rebecca Vince Rebecca.Vince@hull.ac.uk
Senior Lecturer in Health Physiology

Abstract

Purpose: Endothelial dysfunction is a known comorbidity in women with polycystic ovary syndrome (PCOS). The aim was to assess if supervised, moderate intensity exercise could potentially impact markers of endothelial disruption; endothelial cell derived microparticles (EMP).
Methods: The current study investigated the effects of a supervised 8-week moderate intensity exercise programme on EMP in women with PCOS (n=11) and control women free from any known disease (n=10). EMP were enumerated via specific antibody (CD105, CD106) labelling and flow cytometry.
Results: CD105+MP significantly reduced in women with PCOS from pre to post exercise programme, with CD105+ MP reducing from 2114 CD105+ MP per µl platelet free plasma (PFP) to 424 CD105+ MP per µl PFP (p = 0.025). Control women showed no significant change in CD105+ MP (p = 0.25) after completing the same exercise programme. CD106+ MP showed no change in either PCOS (p = 0.95) or control groups (p = 0.99). No significant correlations existed with the changes in endothelial microparticles (EMP) compared to body composition changes as a result of exercise.
Conclusion: Supervised, moderate intensity exercise independent of substantial weight loss reduced circulating CD105+MP, likely reflecting an improvement in endothelial function in women with PCOS compared to healthy control women. Additionally, EMP may be a useful marker for physical improvement in exercise programmes for clinical populations.

Citation

Kirk, R. J., Madden, L. A., Peart, D. J., Aye, M. M., Atkin, S. L., & Vince, R. V. (2019). Circulating endothelial microparticles reduce in concentration following an exercise programme in women with polycystic ovary syndrome. Frontiers in endocrinology, 10(MAR), Article 200. https://doi.org/10.3389/fendo.2019.00200

Journal Article Type	Article
Acceptance Date	Mar 11, 2019
Online Publication Date	Apr 1, 2019
Publication Date	Mar 29, 2019
Deposit Date	Mar 26, 2019
Publicly Available Date	Apr 30, 2019
Journal	Frontiers in Endocrinology
Print ISSN	1664-2392
Electronic ISSN	1664-2392
Publisher	Frontiers Media
Peer Reviewed	Peer Reviewed
Volume	10
Issue	MAR
Article Number	200
DOI	https://doi.org/10.3389/fendo.2019.00200
Keywords	Polycystic ovary syndrome; Endothelial microparticles (EMPs); Exercise; Endothelial function; Obesity
Public URL	https://hull-repository.worktribe.com/output/1428295
Publisher URL	https://www.frontiersin.org/articles/10.3389/fendo.2019.00200/full

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Copyright Statement
© 2019 Kirk, Madden, Peart, Aye, Atkin and Vince. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.