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Impaired heat shock protein 72 expression in women with polycystic ovary syndrome following a supervised exercise programme

Vince, Rebecca V; Kirk, Richard J; Aye, Myint M; Atkin, Stephen L; Madden, Leigh A.


Richard J Kirk

Myint M Aye

Stephen L Atkin


Induction of heat shock protein expression and the heat shock (stress) response are seen in exercise. This exercise-induced response is thought protective against cellular stress through the expression of heat shock proteins. The highly inducible heat shock protein 72 (HSP72) has been shown to be expressed in a number of stress-related conditions, but not investigated in women with polycystic ovary syndrome (PCOS). Twenty-one women (10 controls, 11 with PCOS) concluded an 8-week supervised, moderate-intensity exercise programme. Monocytes and lymphocytes were analysed by flow cytometry for HSP72 expression from blood samples prior to, mid-way and at the completion of the programme. The monocyte HSP72 expression showed an increase from baseline values through mid-way (p = 0.025), and at the completion of the programme (p = 0.011) only in the control group, the PCOS group showed no significant change. This pattern was similar for lymphocyte HSP72 expression where a significant increase was found at the completion of the programme (p = 0.01) only in the control group. The magnitude of increased HSP72 expression following completion of the programme was linked to baseline values only in the control group. In conclusion, increased HSP72 expression to exercise over an 8-week period was seen in control but not in PCOS women, suggesting that there is an impairment of HSP72 expression in response to exercise in these women.


Vince, R. V., Kirk, R. J., Aye, M. M., Atkin, S. L., & Madden, L. A. (2020). Impaired heat shock protein 72 expression in women with polycystic ovary syndrome following a supervised exercise programme. Cell Stress and Chaperones, 25(1), 73-80.

Journal Article Type Article
Acceptance Date Oct 25, 2019
Online Publication Date Nov 16, 2019
Publication Date 2020-01
Deposit Date Nov 17, 2019
Publicly Available Date Nov 18, 2019
Journal Cell Stress and Chaperones
Print ISSN 1355-8145
Electronic ISSN 1466-1268
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 25
Issue 1
Pages 73-80
Keywords Hsp72; Polycystic ovarian syndrome; Heat shock protein
Public URL
Publisher URL
Additional Information Received: 24 July 2019; Revised: 9 October 2019; Accepted: 25 October 2019; First Online: 16 November 2019; : ; : The authors declare that they have no conflict of interest.; : All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.


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