Daniel J. Peart
Implications of a pre-exercise alkalosis-mediated attenuation of HSP72 on its response to a subsequent bout of exercise
Peart, Daniel J.; Kirk, Richard J.; Madden, Leigh A.; Vince, Rebecca V.
Richard J. Kirk
Dr Leigh Madden L.A.Madden@hull.ac.uk
Dr Rebecca Vince Rebecca.Vince@hull.ac.uk
Lecturer in Physiology
The aim of this study was to investigate if a pre-exercise alkalosis-mediated attenuation of HSP72 had any effect on the response of the same stress protein after a subsequent exercise. Seven physically active males [25.0 ± 6.5 years, 182.1 ± 6.0 cm, 74.0 ± 8.3 kg, peak aerobic power (PPO) 316 ± 46 W] performed a repeated sprint exercise (EXB1) following a dose of 0.3 g kg⁻¹ body mass of sodium bicarbonate (BICARB), or a placebo of 0.045 g kg⁻¹ body mass of sodium chloride (PLAC). Participants then completed a 90-min intermittent cycling protocol (EXB2). Monocyte expressed HSP72 was significantly attenuated after EXB1 in BICARB compared to PLAC, however, there was no difference in the HSP72 response to the subsequent EXB2 between conditions. Furthermore there was no difference between conditions for measures of oxidative stress (protein carbonyl and HSP32). These findings confirm the sensitivity of the HSP72 response to exercise-induced changes in acid–base status in vivo, but suggest that the attenuated response has little effect upon subsequent stress in the same day.
|Journal Article Type||Article|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Peart, D. J., Kirk, R. J., Madden, L. A., & Vince, R. V. (2016). Implications of a pre-exercise alkalosis-mediated attenuation of HSP72 on its response to a subsequent bout of exercise. Amino acids, 48(2), 499-504 . https://doi.org/10.1007/s00726-015-2103-1|
|Keywords||HSP72, Bicarbonate, Alkalosis, Stress, Monocyte|
|Copyright Statement||©2016 University of Hull|
|Additional Information||Authors' accepted manuscript of article published in : Amino acids, 2016, v.48, issue 2. The final publication is available at Springer via http://dx.doi.org/10.1007/s00726-015-2103-1|
©2016 University of Hull