Multi-omic analysis of two common p53 mutations: Proteins regulated by mutated p53 as potential targets for immunotherapy
(2022)
Journal Article
Vadakekolathu, J., Boocock, D. J., Pandey, K., Guinn, B. A., Legrand, A., Miles, A. K., …McArdle, S. E. (2022). Multi-omic analysis of two common p53 mutations: Proteins regulated by mutated p53 as potential targets for immunotherapy. Cancers, 14(16), Article 3975. https://doi.org/10.3390/cancers14163975
The p53 protein is mutated in more than 50% of human cancers. Mutated p53 proteins not only lose their normal function but often acquire novel oncogenic functions, a phenomenon termed mutant p53 gain-of-function. Mutant p53 has been shown to affect t... Read More about Multi-omic analysis of two common p53 mutations: Proteins regulated by mutated p53 as potential targets for immunotherapy.