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High INtensity Interval Training in pATiEnts with Intermittent Claudication: A Qualitative Acceptability Study (2024)
Journal Article
Pymer, S., Harwood, A., Ibeggazene, S., McGregor, G., Huang, C., Nicholls, A., Ingle, L., Long, J., Rooms, M., Chetter, I. C., & Twiddy, M. (2024). High INtensity Interval Training in pATiEnts with Intermittent Claudication: A Qualitative Acceptability Study. Annals of vascular surgery, 102, 17-24. https://doi.org/10.1016/j.avsg.2023.11.043

Background: A novel high-intensity interval training (HIIT) program has demonstrated feasibility for patients with intermittent claudication (IC). The aim of this study was to explore patient perspectives of the HIIT program to inform refinement and... Read More about High INtensity Interval Training in pATiEnts with Intermittent Claudication: A Qualitative Acceptability Study.

Exploring pathways to optimise care in malignant bowel obstruction (EPOC): Protocol for a three-phase critical realist approach to theory-led intervention development for shared decision-making (2024)
Journal Article
Bravington, A., Boland, J. W., Greenley, S., Lind, M., Murtagh, F. E., Patterson, M., Pearson, M., & Johnson, M. J. (2024). Exploring pathways to optimise care in malignant bowel obstruction (EPOC): Protocol for a three-phase critical realist approach to theory-led intervention development for shared decision-making. PLoS ONE, 19(1 January), Article e0294218. https://doi.org/10.1371/journal.pone.0294218

Introduction Malignant bowel obstruction is a distressing complication of cancer, causing pain, nausea and vomiting, and often has a poor prognosis. Severe and rapidly developing symptoms, a lack of robust clinical guidelines and the need for multidi... Read More about Exploring pathways to optimise care in malignant bowel obstruction (EPOC): Protocol for a three-phase critical realist approach to theory-led intervention development for shared decision-making.

Effect of intermittently scanned continuous glucose monitoring in people with diabetes with a psychosocial indication for initiation (2024)
Journal Article
Ssemmondo, E., Deshmukh, H., Wilmot, E. G., Adeleke, K. A., Shah, N., Walton, C., Barnes, D., Ryder, R. E., & Sathyapalan, T. (2024). Effect of intermittently scanned continuous glucose monitoring in people with diabetes with a psychosocial indication for initiation. Diabetes, Obesity and Metabolism, 26(4), 1340-1345. https://doi.org/10.1111/dom.15435

Aim: To understand the effect of intermittently scanned continuous glucose monitoring (isCGM) in people with diabetes with a ‘psychosocial’ indication for access. Methods: The study utilized baseline and follow-up data from the Association of British... Read More about Effect of intermittently scanned continuous glucose monitoring in people with diabetes with a psychosocial indication for initiation.

Early ultrasound surveillance of newly-created haemodialysis arteriovenous fistula (2024)
Journal Article
Richards, J., Summers, D., Sidders, A., Allen, E., Thomas, H., Hossain, M. A., Paul, S., Slater, M., Bartlett, M., Lagaac, R., Laing, E., Hopkins, V., Fitzpatrick-Creamer, C., Hudson, C., Parsons, J., Turner, S., Tambyraja, A., Somalanka, S., Hunter, J., Dutta, S., …Walker, A. (2024). Early ultrasound surveillance of newly-created haemodialysis arteriovenous fistula. Kidney International Reports, 9(4), 1005-1019. https://doi.org/10.1016/j.ekir.2024.01.011

Introduction
We assess if ultrasound surveillance of newly-created arteriovenous fistulas (AVFs) can predict nonmaturation sufficiently reliably to justify randomized controlled trial (RCT) evaluation of ultrasound-directed salvage intervention.
Me... Read More about Early ultrasound surveillance of newly-created haemodialysis arteriovenous fistula.

Clinical features of type 1 diabetes in older adults and the impact of intermittently scanned continuous glucose monitoring: An Association of British Clinical Diabetologists (ABCD) study (2024)
Journal Article
Deshmukh, H., Adeleke, K., Wilmot, E. G., Folwell, A., Barnes, D., Walker, N., Saunders, S., Ssemmondo, E., Walton, C., Patmore, J., Ryder, R. E., & Sathyapalan, T. (2024). Clinical features of type 1 diabetes in older adults and the impact of intermittently scanned continuous glucose monitoring: An Association of British Clinical Diabetologists (ABCD) study. Diabetes, Obesity and Metabolism, 26(4), 1333-1339. https://doi.org/10.1111/dom.15434

Aims: To evaluate the clinical features and impact of flash glucose monitoring in older adults with type 1 diabetes (T1D) across age groups defined as young-old, middle-old, and old-old. Materials and Methods: Clinicians were invited to submit anonym... Read More about Clinical features of type 1 diabetes in older adults and the impact of intermittently scanned continuous glucose monitoring: An Association of British Clinical Diabetologists (ABCD) study.

Pharmacodynamics, pharmacokinetics and CYP3A4 interaction potential of the selective P2X3 receptor antagonist filapixant: A randomized multiple ascending-dose study in healthy young men (2024)
Journal Article
Friedrich, C., Singh, D., Francke, K., Klein, S., Hetzel, T., Zolk, O., Gashaw, I., Scheerans, C., & Morice, A. (2024). Pharmacodynamics, pharmacokinetics and CYP3A4 interaction potential of the selective P2X3 receptor antagonist filapixant: A randomized multiple ascending-dose study in healthy young men. British Journal of Clinical Pharmacology, https://doi.org/10.1111/bcp.16091

Aims: We report on investigations exploring the P2X3-receptor antagonist filapixant's effect on taste perception and cough-reflex sensitivity and describe its pharmacokinetics, including its CYP3A4-interaction potential. Methods: In a randomized, pla... Read More about Pharmacodynamics, pharmacokinetics and CYP3A4 interaction potential of the selective P2X3 receptor antagonist filapixant: A randomized multiple ascending-dose study in healthy young men.

Advancements in the management of obesity: a review of current evidence and emerging therapies (2024)
Journal Article
Abdalla Ahmed, M. A., Ssemmondo, E., Mark-Wagstaff, C., & Sathyapalan, T. (2024). Advancements in the management of obesity: a review of current evidence and emerging therapies. Expert Review of Endocrinology and Metabolism, 19(3), 257-268. https://doi.org/10.1080/17446651.2024.2347258

Introduction: Obesity is the modern world’s current epidemic, with substantial health and economic impact. This study aimed to provide a narrative overview of the past, currently available, and future treatment options that offer therapeutic and prev... Read More about Advancements in the management of obesity: a review of current evidence and emerging therapies.

High-resolution CT phenotypes in pulmonary sarcoidosis: a multinational Delphi consensus study (2023)
Journal Article
Desai, S. R., Sivarasan, N., Johannson, K. A., George, P. M., Culver, D. A., Devaraj, A., Lynch, D. A., Milne, D., Renzoni, E., Nunes, H., Sverzellati, N., Spagnolo, P., Baughman, R. P., Yadav, R., Piciucchi, S., Walsh, S. L. F., Kouranos, V., Wells, A. U., Anderson, A., Morgenthau, A., …Inoue, Y. (in press). High-resolution CT phenotypes in pulmonary sarcoidosis: a multinational Delphi consensus study. The lancet. Respiratory medicine, https://doi.org/10.1016/S2213-2600%2823%2900267-9

One view of sarcoidosis is that the term covers many different diseases. However, no classification framework exists for the future exploration of pathogenetic pathways, genetic or trigger predilections, patterns of lung function impairment, or treat... Read More about High-resolution CT phenotypes in pulmonary sarcoidosis: a multinational Delphi consensus study.

Identification of biomarkers for the early detection of non-small cell lung cancer: a systematic review and meta-analysis (2023)
Journal Article
Mohamed, E., García Martínez, D. J., Hosseini, M. S., Yoong, S. Q., Fletcher, D., Hart, S., & Guinn, B. A. (2024). Identification of biomarkers for the early detection of non-small cell lung cancer: a systematic review and meta-analysis. Carcinogenesis, 45(1-2), Article bgad091. https://doi.org/10.1093/carcin/bgad091

Lung cancer (LC) causes few symptoms in the earliest stages, leading to one of the highest mortality rates among cancers. Low-dose computerised tomography (LDCT) is used to screen high-risk individuals, reducing the mortality rate by 20%. However, LD... Read More about Identification of biomarkers for the early detection of non-small cell lung cancer: a systematic review and meta-analysis.

Molecular Mechanisms Linking Diabetes with Increased Risk of Thrombosis (2023)
Journal Article
Batten, L., Sathyapalan, T., & Palmer, T. M. (2023). Molecular Mechanisms Linking Diabetes with Increased Risk of Thrombosis. International Journal of Molecular Sciences, 24(24), Article 17465. https://doi.org/10.3390/ijms242417465

This review will provide an overview of what is currently known about mechanisms linking poor glycaemic control with increased thrombotic risk. The leading causes of death in people with diabetes are strokes and cardiovascular disease. Significant mo... Read More about Molecular Mechanisms Linking Diabetes with Increased Risk of Thrombosis.

Supervised Exercise Therapy for Intermittent Claudication: A Propensity Score Matched Analysis of Retrospective Data on Long Term Cardiovascular Outcomes (2023)
Journal Article
Ravindhran, B., Lim, A. J., Kurian, T., Walshaw, J., Hitchman, L. H., Lathan, R., Smith, G. E., Carradice, D., Chetter, I. C., & Pymer, S. (in press). Supervised Exercise Therapy for Intermittent Claudication: A Propensity Score Matched Analysis of Retrospective Data on Long Term Cardiovascular Outcomes. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, https://doi.org/10.1016/j.ejvs.2023.11.040

Objective: This study aimed to explore the long term outcomes of patients with intermittent claudication (IC) who completed supervised exercise therapy (SET) vs. those who declined or prematurely discontinued SET, focusing on the incidence of chronic... Read More about Supervised Exercise Therapy for Intermittent Claudication: A Propensity Score Matched Analysis of Retrospective Data on Long Term Cardiovascular Outcomes.

Fixed-duration therapy comes of age in CLL: long-term results of MURANO and CLL14 trials (2023)
Journal Article
Molica, S., & Allsup, D. (2023). Fixed-duration therapy comes of age in CLL: long-term results of MURANO and CLL14 trials. Expert Review of Anticancer Therapy, https://doi.org/10.1080/14737140.2023.2288899

Introduction: Chronic lymphocytic leukemia (CLL) management has witnessed a transformative shift with the advent of time-limited venetoclax and anti-CD20 monoclonal antibody (mAb) regimens, as exemplified by the groundbreaking MURANO and CLL14 trials... Read More about Fixed-duration therapy comes of age in CLL: long-term results of MURANO and CLL14 trials.

Targeting TP53 disruption in chronic lymphocytic leukemia: Current strategies and future directions (2023)
Journal Article
Molica, S., Tam, C., Allsup, D., & Polliack, A. (in press). Targeting TP53 disruption in chronic lymphocytic leukemia: Current strategies and future directions. Hematological Oncology, https://doi.org/10.1002/hon.3238

In the modern era of Chronic Lymphocytic Leukemia (CLL) targeted therapy, the loss of p53 function due to genetic abnormalities remains a significant challenge. This is because even targeted agents, which are currently the mainstay of treatment for C... Read More about Targeting TP53 disruption in chronic lymphocytic leukemia: Current strategies and future directions.

Consensus goals and standards for specialist cough clinics: the NEUROCOUGH international Delphi study (2023)
Journal Article
Song, W. J., Dupont, L., Birring, S. S., Chung, K. F., Dąbrowska, M., Dicpinigaitis, P., Ribas, C. D., Fontana, G., Gibson, P. G., Guilleminault, L., Hull, J. H., Idzko, M., Kardos, P., Kim, H. J., Lai, K., Lavorini, F., Millqvist, E., Morice, A. H., Niimi, A., Parker, S. M., …McGarvey, L. P. (2023). Consensus goals and standards for specialist cough clinics: the NEUROCOUGH international Delphi study. ERJ Open Research, 9(6), Article 00618-2023. https://doi.org/10.1183/23120541.00618-2023

Background Current guidelines on the management of chronic cough do not provide recommendations for the operation of specialist cough clinics. The objective of the present study was to develop expert consensus on goals and standard procedures for spe... Read More about Consensus goals and standards for specialist cough clinics: the NEUROCOUGH international Delphi study.

Molecular mechanisms of action of negative pressure wound therapy: A systematic review (2023)
Journal Article
Ravindhran, B., Schafer, N., Howitt, A., Carradice, D., Smith, G., & Chetter, I. (2023). Molecular mechanisms of action of negative pressure wound therapy: A systematic review. Expert Reviews in Molecular Medicine, 25, Article e29. https://doi.org/10.1017/erm.2023.24

Negative pressure wound therapy (NPWT) has significantly advanced wound care and continues to find new applications. Its effects at a molecular level however, remain a subject of debate. The aim of this systematic review is to summarize the current e... Read More about Molecular mechanisms of action of negative pressure wound therapy: A systematic review.

Exploration of the correlation of serum polychlorinated biphenyl levels with luteal phase hormonal parameters and infertility in women with or without polycystic ovary syndrome (2023)
Journal Article
Butler, A. E., Brennan, E., Drage, D. S., Sathyapalan, T., & Atkin, S. L. (2023). Exploration of the correlation of serum polychlorinated biphenyl levels with luteal phase hormonal parameters and infertility in women with or without polycystic ovary syndrome. Frontiers in endocrinology, 14, Article 1270949. https://doi.org/10.3389/fendo.2023.1270949

Introduction: Polychlorinated biphenyls (PCBs) are organic lipophilic pollutants that accumulate in the body. Previous research has linked PCBs with menstrual function; therefore, this study was undertaken to investigate the correlation of PCBs with... Read More about Exploration of the correlation of serum polychlorinated biphenyl levels with luteal phase hormonal parameters and infertility in women with or without polycystic ovary syndrome.

Feasibility of delivering supervised exercise training following surgical resection and during adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PRECISE): a case series (2023)
Journal Article
Brown, M., O’Connor, D., Turkington, R., Eatock, M., Vince, R., Hulme, C., Bowdery, R., Robinson, R., Wadsley, J., Maraveyas, A., & Prue, G. (2023). Feasibility of delivering supervised exercise training following surgical resection and during adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PRECISE): a case series. BMC Sports Science, Medicine and Rehabilitation, 15(1), Article 116. https://doi.org/10.1186/s13102-023-00722-3

Introduction: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive neoplasm, with surgical resection and adjuvant chemotherapy the only curative treatment. Treatment-related toxicities place a considerable burden on patients although exercise tra... Read More about Feasibility of delivering supervised exercise training following surgical resection and during adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PRECISE): a case series.