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TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids (2010)
Journal Article
Sadofsky, L. R., Boa, A. N., Maher, S. A., Birrell, M. A., Belvisi, M. G., & Morice, A. H. (2011). TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids. Pharmacological research : the official journal of the Italian Pharmacological Society, 63(1), 30-36. https://doi.org/10.1016/j.phrs.2010.11.004

The nociceptor TRPA1 is thought to be activated through covalent modification of specific cysteine residues on the N terminal of the channel. The precise mechanism of covalent modification with unsaturated carbonyl-containing compounds is unclear, th... Read More about TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids.

Quantifying chronic cough: Objective versus subjective measurements (2010)
Journal Article
Faruqi, S., Thompson, R., Wright, C., Sheedy, W., & Morice, A. H. (2011). Quantifying chronic cough: Objective versus subjective measurements. Respirology : official journal of the Asian Pacific Society of Respirology, 16(2), 314-320. https://doi.org/10.1111/j.1440-1843.2010.01893.x

Background and objective: The assessment of chronic cough has been improved by the development of objective ambulatory cough monitoring systems and subjective quality of life questionnaires. Experimental induction of cough is a useful tool in the ass... Read More about Quantifying chronic cough: Objective versus subjective measurements.

Statins and ischaemia reperfusion injury: a molecular biological review (2010)
Journal Article
N.A. Abdul Rahman, M., & C. Chetter, I. (2010). Statins and ischaemia reperfusion injury: a molecular biological review. Current Vascular Pharmacology, 8(6), 831-835. https://doi.org/10.2174/157016110793563780

The 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase inhibitors (statins) are a class of drug used to lower low-density lipoprotein (LDL) levels. However, in recent years, statins have been shown to possess a pleiotropic effect beyond its choleste... Read More about Statins and ischaemia reperfusion injury: a molecular biological review.

Atorvastatin increases 25-hydroxy vitamin D concentrations in patients with polycystic ovary syndrome (2010)
Journal Article
Sathyapalan, T., Shepherd, J., Arnett, C., Coady, A.-M., Kilpatrick, E. S., & Atkin, S. L. (2010). Atorvastatin increases 25-hydroxy vitamin D concentrations in patients with polycystic ovary syndrome. Clinical Chemistry, 56(11), 1696-1700. https://doi.org/10.1373/clinchem.2010.144014

BACKGROUND: It has been shown that many women with polycystic ovary syndrome (PCOS) are 25-hydroxyvitamin D (25OHD) insufficient. Both statin treatment and vitamin D supplementation have been shown to improve biochemical hyperandrogenemia, insulin re... Read More about Atorvastatin increases 25-hydroxy vitamin D concentrations in patients with polycystic ovary syndrome.

Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression (2010)
Journal Article
Bournazos, S., Grinfeld, J., Alexander, K. M., Murchison, J. T., Wallace, W. A., McFarlane, P., Hirani, N., Simpson, A. J., Dransfield, I., & Hart, S. P. (2010). Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression. BMC Pulmonary Medicine, 10(1), Article ARTN 51. https://doi.org/10.1186/1471-2466-10-51

Background: A significant genetic component has been described for idiopathic pulmonary fibrosis (IPF). The R131H (rs1801274) polymorphism of the IgG receptor FcγRIIa determines receptor affinity for IgG subclasses and is associated with several chro... Read More about Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression.

Fcγ Receptor IIIb (CD16b) Polymorphisms are Associated with Susceptibility to Idiopathic Pulmonary Fibrosis (2010)
Journal Article
Bournazos, S., Bournazou, I., Murchison, J. T., Wallace, W. A., McFarlane, P., Hirani, N., Simpson, A. J., Dransfield, I., & Hart, S. P. (2010). Fcγ Receptor IIIb (CD16b) Polymorphisms are Associated with Susceptibility to Idiopathic Pulmonary Fibrosis. Lung, 188(6), 475-481. https://doi.org/10.1007/s00408-010-9262-3

An excess of neutrophils in the alveoli and lung interstitium has been described in idiopathic pulmonary fibrosis (IPF). Engagement of neutrophil Fcγ receptors with IgG complexes may contribute to the pathogenesis of IPF. The neutrophil FcγRIIIb rece... Read More about Fcγ Receptor IIIb (CD16b) Polymorphisms are Associated with Susceptibility to Idiopathic Pulmonary Fibrosis.

Clinical expert guidelines for the management of cough in lung cancer: Report of a UK task group on cough (2010)
Journal Article
Molassiotis, A., Smith, J. A., Bennett, M. I., Blackhall, F., Taylor, D., Zavery, B., Harle, A., Booton, R., Rankin, E. M., Lloyd-Williams, M., & Morice, A. H. (2010). Clinical expert guidelines for the management of cough in lung cancer: Report of a UK task group on cough. Cough, 6(1), Article 9. https://doi.org/10.1186/1745-9974-6-9

Background: Cough is a common and distressing symptom in lung cancer patients. The clinical management of cough in lung cancer patients is suboptimal with limited high quality research evidence available. The aim of the present paper is to present a... Read More about Clinical expert guidelines for the management of cough in lung cancer: Report of a UK task group on cough.

A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal ao (2010)
Journal Article
Rahman, M. A., Khan, J. A., Mazari, F. A. K., Mockford, K., McCollum, P. T., & Chetter, I. (2011). A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal ao. Annals of vascular surgery, 25(1), 32-38. https://doi.org/10.1016/j.avsg.2010.06.006

BackgroundA double-blind, randomized controlled trial was carried out to study the effects of statins on matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in areas of peak and low abdominal aortic aneurysm (A... Read More about A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal ao.

Computerized dynamic posturography in the objective assessment of balance in patients with intermittent claudication (2010)
Journal Article
Mockford, K. A., Mazari, F. A. K., Jordan, A. R., Vanicek, N., Chetter, I. C., & Coughlin, P. A. (2011). Computerized dynamic posturography in the objective assessment of balance in patients with intermittent claudication. Annals of vascular surgery, 25(2), 182-190. https://doi.org/10.1016/j.avsg.2010.07.021

One-third of all elderly patients fall each year and impaired balance has been recognized as a specific risk factor. Intermittent claudication is common among the elderly population, affecting approximately 5% of the population over the age of 50. Th... Read More about Computerized dynamic posturography in the objective assessment of balance in patients with intermittent claudication.

Treatment of cystic fibrosis associated cutaneous vasculitis with chloroquine (2010)
Journal Article
Molyneux, I. D., Moon, T., Webb, A. K., & Morice, A. H. (2010). Treatment of cystic fibrosis associated cutaneous vasculitis with chloroquine. Journal of Cystic Fibrosis, 9(6), 439-441. https://doi.org/10.1016/j.jcf.2010.08.017

Vasculitis is a well recognised complication of Cystic Fibrosis. Corticosteroids are the mainstay of treatment but some cases can be resistant and may require additional disease modifying agents.We describe a case of steroid resistant cutaneous vascu... Read More about Treatment of cystic fibrosis associated cutaneous vasculitis with chloroquine.

Hull early walking aid for rehabilitation of transtibial amputees - randomized controlled trial (HEART) (2010)
Journal Article
Mazari, F. A. K., Mockford, K., Vanicek, N., Barnett, C., Khan, J. A., Brown, B., Smith, L., Polman, R. C., Hancock, A., & Chetter, I. C. (2010). Hull early walking aid for rehabilitation of transtibial amputees - randomized controlled trial (HEART). Journal of vascular surgery, 52(6), 1564-1571. https://doi.org/10.1016/j.jvs.2010.07.006

Purpose: To compare articulated and nonarticulated early walking aids (EWAs) for clinical and quality-of-life outcomes in transtibial amputees. Methods: Patients undergoing lower limb amputation in a tertiary-care vascular surgical unit were screened... Read More about Hull early walking aid for rehabilitation of transtibial amputees - randomized controlled trial (HEART).

Disparate effects of atorvastatin compared with simvastatin on C-reactive protein concentrations in patients with Type 2 diabetes (2010)
Journal Article
Sathyapalan, T., Atkin, S. L., & Kilpatrick, E. S. (2010). Disparate effects of atorvastatin compared with simvastatin on C-reactive protein concentrations in patients with Type 2 diabetes. Diabetes Care, 33(9), 1948-1950. https://doi.org/10.2337/dc10-0201

OBJECTIVE - Reduction in LDL and high sensitivity (hs) C-reactive protein (CRP) are independent indicators of successful cardiovascular risk reduction with statins. This study compared the effect of equivalent LDL-lowering doses of simvastatin and at... Read More about Disparate effects of atorvastatin compared with simvastatin on C-reactive protein concentrations in patients with Type 2 diabetes.

Randomized clinical trial of tranexamic acid-free fibrin sealant during vascular surgical procedures (2010)
Journal Article
Chalmers, R. T. A., Darling, R. C., Wingard, J. T., Chetter, I., Cutler, B., Kern, J. A., & Hart, J. C. (2010). Randomized clinical trial of tranexamic acid-free fibrin sealant during vascular surgical procedures. British journal of surgery, 97(12), 1784-1789. https://doi.org/10.1002/bjs.7235

Background: This study evaluated the safety and haemostatic effectiveness of a fibrin sealant (EVICELTM Fibrin Sealant (Human)) during vascular surgery. Methods: This prospective randomized controlled trial compared the haemostatic effectiveness of f... Read More about Randomized clinical trial of tranexamic acid-free fibrin sealant during vascular surgical procedures.

COPD in young patients: A pre-specified analysis of the four-year trial of tiotropium (UPLIFT) (2010)
Journal Article
Morice, A. H., Celli, B., Kesten, S., Lystig, T., Tashkin, D., & Decramer, M. (2010). COPD in young patients: A pre-specified analysis of the four-year trial of tiotropium (UPLIFT). Respiratory medicine, 104(11), 1659-1667. https://doi.org/10.1016/j.rmed.2010.07.016

Whilst recent large-scale studies have provided much evidence on the natural history and therapeutic response in patients with chronic obstructive pulmonary disease (COPD), relatively little is known about the effect in younger patients. We report a... Read More about COPD in young patients: A pre-specified analysis of the four-year trial of tiotropium (UPLIFT).

Validation of the ERS standard citric acid cough challenge in healthy adult volunteers (2010)
Journal Article
Wright, C. E., Jackson, J., Thompson, R. L., & Morice, A. H. (2010). Validation of the ERS standard citric acid cough challenge in healthy adult volunteers. Cough, 6(1), Article 8. https://doi.org/10.1186/1745-9974-6-8

Protocols measuring cough sensitivity can vary in terms of nebuliser, tussive agent, single and dose response. A definitive method for measuring cough sensitivity needs to be established. The ERS guidelines recommend the KoKo DigiDoser (KD) delivery... Read More about Validation of the ERS standard citric acid cough challenge in healthy adult volunteers.

Chronic cough associated with Crohn's disease (2010)
Journal Article
Faruqi, S., Avery, G., & Morice, A. H. (2010). Chronic cough associated with Crohn's disease. Cough, 6(1), https://doi.org/10.1186/1745-9974-6-6

A 62-year-old man presented with chronic dry cough. He was known to have Crohn's disease which was in remission. A plain chest radiograph demonstrated bilateral apical infiltrates. A HRCT of the chest showed normal proximal airways. Stenosis of mediu... Read More about Chronic cough associated with Crohn's disease.

Kinematic adaptations to ischemic pain in claudicants during continuous walking (2010)
Journal Article
Mockford, K. A., Vanicek, N., Jordan, A., Chetter, I. C., & Coughlin, P. A. (2010). Kinematic adaptations to ischemic pain in claudicants during continuous walking. Gait and Posture, 32(3), 395-399. https://doi.org/10.1016/j.gaitpost.2010.06.021

Intermittent claudication has been associated with impaired gait and balance. The study aim was to compare gait adaptations over time between claudicants classified with good versus poor balance. Kinematic data were collected from 24 claudicants duri... Read More about Kinematic adaptations to ischemic pain in claudicants during continuous walking.

Prospective observational study for comparison of use of Short Form-36 dimension scores and patient responses for derivation of preference based Short Form-6D index to calculate of quality adjusted life years (QALYs) for economic analyses in patients with (2010)
Presentation / Conference Contribution
Mazari, F., Abdul Rahman, H., Khan, J., Mockford, K., McCollum, P., & Chetter, I. Prospective observational study for comparison of use of Short Form-36 dimension scores and patient responses for derivation of preference based Short Form-6D index to calculate of quality adjusted life years (QALYs) for economic analyses in patients with