All Outputs (72)

The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence (2021)
Journal Article
Abdalla, M. A., Deshmukh, H., Atkin, S., & Sathyapalan, T. (2021). The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence. Therapeutic Advances in Endocrinology and Metabolism, 12, https://doi.org/10.1177/2042018821989238

© The Author(s), 2021. Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age. Metabolic consequences associated with PCOS include, but are not limited to, insulin resistance (IR), type 2... Read More about The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence.

Platelet releasate normalises the compromised muscle regeneration in a mouse model of hyperlipidaemia (2021)
Journal Article
Barlow, J., Sfyri, P. P., Mitchell, R., Verpoorten, S., Scully, D., Andreou, C., Papadopoulos, P., Patel, K., & Matsakas, A. (2021). Platelet releasate normalises the compromised muscle regeneration in a mouse model of hyperlipidaemia. Experimental Physiology, 106(3), 700-713. https://doi.org/10.1113/ep088937

Muscle satellite cells are important stem cells for skeletal muscle regeneration and repair after injury. ApoE‐deficient mice, an established mouse model of hyperlipidaemia and atherosclerosis, show evidence of oxidative stress‐induced lesions and fa... Read More about Platelet releasate normalises the compromised muscle regeneration in a mouse model of hyperlipidaemia.

Evaluating a web- and telephone-based personalised exercise intervention for individuals living with metastatic prostate cancer (ExerciseGuide): protocol for a pilot randomised controlled trial (2021)
Journal Article
Evans, H. E., Forbes, C. C., Galvão, D. A., Vandelanotte, C., Newton, R. U., Wittert, G., Chambers, S., Vincent, A. D., Kichenadasse, G., Brook, N., Girard, D., & Short, C. E. (2021). Evaluating a web- and telephone-based personalised exercise intervention for individuals living with metastatic prostate cancer (ExerciseGuide): protocol for a pilot randomised controlled trial. Pilot and Feasibility Studies, 7(1), Article 21. https://doi.org/10.1186/s40814-020-00763-2

Introduction: Preliminary research has shown the effectiveness of supervised exercise-based interventions in alleviating sequela resulting from metastatic prostate cancer. Despite this, many individuals do not engage in sufficient exercise to gain th... Read More about Evaluating a web- and telephone-based personalised exercise intervention for individuals living with metastatic prostate cancer (ExerciseGuide): protocol for a pilot randomised controlled trial.

Therapeutics for type-2 diabetes mellitus: a glance at the recent inclusions and novel agents under development for use in clinical practice (2021)
Journal Article
Shah, N., Abdalla, M. A., Deshmukh, H., & Sathyapalan, T. (2021). Therapeutics for type-2 diabetes mellitus: a glance at the recent inclusions and novel agents under development for use in clinical practice. Therapeutic Advances in Endocrinology and Metabolism, 12, https://doi.org/10.1177/20420188211042145

Diabetes mellitus (DM) is a chronic, progressive, and multifaceted illness resulting in significant physical and psychological detriment to patients. As of 2019, 463 million people are estimated to be living with DM worldwide, out of which 90% have t... Read More about Therapeutics for type-2 diabetes mellitus: a glance at the recent inclusions and novel agents under development for use in clinical practice.

The effect of spironolactone on cardiovascular function and markers of fibrosis in people at increased risk of developing heart failure: the heart 'OMics' in AGEing (HOMAGE) randomized clinical trial (2020)
Journal Article
Cleland, J. G. F., Ferreira, J. P., Mariottoni, B., Pellicori, P., Cuthbert, J., Verdonschot, J. A. J., Petutschnigg, J., Ahmed, F. Z., Cosmi, F., Brunner La Rocca, H. P., Mamas, M. A., Clark, A. L., Edelmann, F., Pieske, B., Khan, J., McDonald, K., Rouet, P., Staessen, J. A., Mujaj, B., González, A., …the HOMAGE Trial Committees and Investigators. (2021). The effect of spironolactone on cardiovascular function and markers of fibrosis in people at increased risk of developing heart failure: the heart 'OMics' in AGEing (HOMAGE) randomized clinical trial. European Heart Journal, 42(6), 684-696. https://doi.org/10.1093/eurheartj/ehaa758

Aims: To investigate the effects of spironolactone on fibrosis and cardiac function in people at increased risk of developing heart failure. Methods and results: Randomized, open-label, blinded-endpoint trial comparing spironolactone (50 mg/day) or c... Read More about The effect of spironolactone on cardiovascular function and markers of fibrosis in people at increased risk of developing heart failure: the heart 'OMics' in AGEing (HOMAGE) randomized clinical trial.

Considering the feasibility, tolerability and safety of high intensity interval training as a novel treatment for patients with intermittent claudication (2020)
Journal Article
Pymer, S., Ibeggazene, S., Palmer, J., Smith, G. E., Carroll, S., Ingle, L., Harwood, A., & Chetter, I. C. (2021). Considering the feasibility, tolerability and safety of high intensity interval training as a novel treatment for patients with intermittent claudication. Journal of Cardiopulmonary Rehabilitation and Prevention, 41(3), 188-193. https://doi.org/10.1097/HCR.0000000000000551

Considering the Feasibility, Tolerability and Safety of High-Intensity Interval Training as a Novel Treatment for Patients with Intermittent Claudication.

Structured Abstract
Purpose: This study assessed the feasibility, tolerability, safety and... Read More about Considering the feasibility, tolerability and safety of high intensity interval training as a novel treatment for patients with intermittent claudication.

Relation Between Thyroid Function and Mortality in Patients With Chronic Heart Failure (2020)
Journal Article
Samuel, N. A., Cuthbert, J. J., Brown, O. I., Kazmi, S., Cleland, J. G., Rigby, A. S., & Clark, A. L. (2021). Relation Between Thyroid Function and Mortality in Patients With Chronic Heart Failure. The American journal of cardiology, 139, 57-63. https://doi.org/10.1016/j.amjcard.2020.10.034

Thyroid dysfunction is common in patients with chronic heart failure (CHF), but there is conflicting evidence regarding its prognostic significance. We investigated the relation between thyroid function and prognosis in a large, well characterized co... Read More about Relation Between Thyroid Function and Mortality in Patients With Chronic Heart Failure.

CANcer BEhavioural nutrition and exercise feasibility trial (CanBenefit); phase I qualitative interview findings (2020)
Journal Article
Swan, F., Chen, H., Forbes, C. C., Johnson, M. J., & Lind, M. (in press). CANcer BEhavioural nutrition and exercise feasibility trial (CanBenefit); phase I qualitative interview findings. Journal of Geriatric Oncology, https://doi.org/10.1016/j.jgo.2020.09.026

Background: Older people with lung cancer are often frail and unfit due to their cancer and co-morbidities and may tolerate cancer treatments poorly. Physical activity (PA) and a healthy diet offer quality of life benefit to people with cancer before... Read More about CANcer BEhavioural nutrition and exercise feasibility trial (CanBenefit); phase I qualitative interview findings.

Examining the Priorities, Needs and Preferences of Men with Metastatic Prostate Cancer in Designing a Personalised eHealth Exercise Intervention (2020)
Journal Article
Evans, H. E., Forbes, C. C., Vandelanotte, C., Galvão, D. A., Newton, R. U., Wittert, G., Chambers, S., Kichenadasse, G., Brook, N., Girard, D., & Short, C. E. (2021). Examining the Priorities, Needs and Preferences of Men with Metastatic Prostate Cancer in Designing a Personalised eHealth Exercise Intervention. International Journal of Behavioral Medicine, 28(4), 431-443. https://doi.org/10.1007/s12529-020-09932-2

Background: Few individuals with metastatic prostate cancer have access to prostate cancer-specific exercise support, despite demonstrated benefits. eHealth tools, such as websites, may be viable options for increasing access. To be effective and acc... Read More about Examining the Priorities, Needs and Preferences of Men with Metastatic Prostate Cancer in Designing a Personalised eHealth Exercise Intervention.

‘I don’t talk about my distress to others; I feel that I have to suffer my problems..’ Voices of Indian women with breast cancer: a qualitative interview study (2020)
Journal Article
Daniel, S., Venkateswaran, C., Hutchinson, A., & Johnson, M. J. (2020). ‘I don’t talk about my distress to others; I feel that I have to suffer my problems..’ Voices of Indian women with breast cancer: a qualitative interview study. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, https://doi.org/10.1007/s00520-020-05756-8

Background: Breast cancer is the commonest form of cancer among women globally, including in India. The rising incidence in the developing world is thought to be due to increased life expectancy, urbanization and adoption of western lifestyles. A rec... Read More about ‘I don’t talk about my distress to others; I feel that I have to suffer my problems..’ Voices of Indian women with breast cancer: a qualitative interview study.

Postload glucose spike but not fasting glucose determines prognosis after myocardial infarction in patients without known or newly diagnosed diabetes (2020)
Journal Article
Chattopadhyay, S., George, A., John, J., & Sathyapalan, T. (2021). Postload glucose spike but not fasting glucose determines prognosis after myocardial infarction in patients without known or newly diagnosed diabetes. Journal of Diabetes, 13(3), 191-199. https://doi.org/10.1111/1753-0407.13111

Background: The effect of postload glucose spikes (PGS), the difference between 2 hour post-load plasma glucose (2hPLPG) and fasting plasma glucose (FPG), on post–myocardial infarction (post-MI) prognosis in nondiabetic patients is unexplored. Method... Read More about Postload glucose spike but not fasting glucose determines prognosis after myocardial infarction in patients without known or newly diagnosed diabetes.

Implementation of geriatric assessment in oncology settings: A systematic realist review (2020)
Journal Article
McKenzie, G. A., Bullock, A. F., Greenley, S. L., Lind, M. J., Johnson, M. J., & Pearson, M. (2021). Implementation of geriatric assessment in oncology settings: A systematic realist review. Journal of Geriatric Oncology, 12(1), 22-33. https://doi.org/10.1016/j.jgo.2020.07.003

Older adults with cancer are more likely to have worse clinical outcomes than their younger counterparts, and shared decision-making can be difficult, due to both complexity from adverse ageing and under-representation in clinical trials. Geriatric a... Read More about Implementation of geriatric assessment in oncology settings: A systematic realist review.