All Outputs (701)

Platelet Actin Cytoskeletal Reversibility is Cyclic Nucleotide and Matrix Type Dependent (2019)
Thesis
Atkinson, L. (2019). Platelet Actin Cytoskeletal Reversibility is Cyclic Nucleotide and Matrix Type Dependent. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4912485

Platelets circulate in the vasculature in a quiescent state due to the presence of endothelial-derived nitric oxide (NO) and prostacyclin (PGI2). However, this inhibition is relieved upon vascular injury due to exposed matrix proteins, which cause pl... Read More about Platelet Actin Cytoskeletal Reversibility is Cyclic Nucleotide and Matrix Type Dependent.

The effects of opioids on cognition in older adults with cancer and chronic non-cancer pain: A systematic review (2019)
Journal Article
Pask, S., Dell’Olio, M., Murtagh, F. E., & Boland, J. W. (2020). The effects of opioids on cognition in older adults with cancer and chronic non-cancer pain: A systematic review. Journal of pain and symptom management, 59(4), 871-893. https://doi.org/10.1016/j.jpainsymman.2019.10.022

Context
Opioids are prescribed to manage moderate to severe pain and can be used with older adults; however, they may lead to several adverse effects, including cognitive impairment.

Objective
To identify, appraise and synthesise evidence on i)... Read More about The effects of opioids on cognition in older adults with cancer and chronic non-cancer pain: A systematic review.

Palliative care in Parkinson's disease: Review of needs assessment tools (2019)
Journal Article
Richfield, E. W., & Johnson, M. J. (2020). Palliative care in Parkinson's disease: Review of needs assessment tools. Annals of palliative medicine, 9, S6-S15. https://doi.org/10.21037/apm.2019.09.18

Palliative care in Parkinson’s disease (PD) has developed significantly in the past five years. The presence of unmet palliative care need, similar to that in malignant conditions, is well established, but may not always be identified by clinicians i... Read More about Palliative care in Parkinson's disease: Review of needs assessment tools.

Identification and assessment of breathlessness in clinical practice: a systematic review and narrative synthesis. (2019)
Journal Article
Elliott-Button, H., Johnson, M. J., Nwulu, U., & Clark, J. (2020). Identification and assessment of breathlessness in clinical practice: a systematic review and narrative synthesis. Journal of pain and symptom management, 59(3), 724-733.e19. https://doi.org/10.1016/j.jpainsymman.2019.10.014

Context: Breathlessness is common in chronic conditions but often goes unidentified by clinicians. It is important to understand how identification and assessment of breathlessness occurs across health care settings, to promote routine outcome assess... Read More about Identification and assessment of breathlessness in clinical practice: a systematic review and narrative synthesis..

Optimising platelet secretomes to deliver robust tissue-specific regeneration (2019)
Journal Article
Scully, D., Sfyri, P., Wilkinson, H. N., Acebes‐Huerta, A., Verpoorten, S., Muñoz‐Turrillas, M. C., Parnell, A., Patel, K., Hardman, M. J., Gutiérrez, L., & Matsakas, A. (2020). Optimising platelet secretomes to deliver robust tissue-specific regeneration. Journal of tissue engineering and regenerative medicine, 14(1), 82-98. https://doi.org/10.1002/term.2965

Promoting cell proliferation is the cornerstone of most tissue regeneration therapies. As platelet-based applications promote cell division and can be customised for tissue-specific efficacy, this makes them strong candidates for developing novel reg... Read More about Optimising platelet secretomes to deliver robust tissue-specific regeneration.

Loss of CD36 protects against diet-induced obesity but results in impaired muscle stem cell function, delayed muscle regeneration and hepatic steatosis (2019)
Journal Article
Verpoorten, S., Sfyri, P., Scully, D., Mitchell, R., Tzimou, A., Mougios, V., Patel, K., & Matsakas, A. (2020). Loss of CD36 protects against diet-induced obesity but results in impaired muscle stem cell function, delayed muscle regeneration and hepatic steatosis. Acta Physiologica, 228(3), https://doi.org/10.1111/apha.13395

Aim: The prevalence of obesity is a major risk factor for cardiovascular and metabolic diseases including impaired skeletal muscle regeneration. Since skeletal muscle regenerative capacity is regulated by satellite cells, we aimed to investigate whet... Read More about Loss of CD36 protects against diet-induced obesity but results in impaired muscle stem cell function, delayed muscle regeneration and hepatic steatosis.

Presurgery conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease (2019)
Journal Article
Palmer, J., Pymer, S., Smith, G. E., Harwood, A. E., Ingle, L., Huang, C., & Chetter, I. C. (2019). Presurgery conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease. The Cochrane database of systematic reviews, 2019(9), Article CD013407. https://doi.org/10.1002/14651858.cd013407

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

To assess the effectiveness of prehabilitation (preoperative exercise, either alone or in combination with nutritional or psychological interventions or both)... Read More about Presurgery conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease.

Family display, family type, or community? Limitations in the application of a concept (2019)
Journal Article
Walsh, J., McNamee, S., & Seymour, J. (2019). Family display, family type, or community? Limitations in the application of a concept. Families, Relationships and Societies, https://doi.org/10.1332/204674319x15647592551202

In this paper we develop the concept of family display by responding to David Morgan’s suggestion that researchers should consider whether ‘family displays’ are used to convey a ‘type’ of Family. We do so by applying the concept to the accounts of mi... Read More about Family display, family type, or community? Limitations in the application of a concept.

Tissue iron promotes wound repair via M2 macrophage polarisation and the chemokines CCL17 and CCL22 (2019)
Journal Article
Wilkinson, H. N., Roberts, E. R., Stafford, A. R., Banyard, K. L., Matteucci, P., Mace, K. A., & Hardman, M. J. (2019). Tissue iron promotes wound repair via M2 macrophage polarisation and the chemokines CCL17 and CCL22. American Journal of Pathology, 189(11), 2196-2208. https://doi.org/10.1016/j.ajpath.2019.07.015

Macrophages are important for effective iron recycling and erythropoiesis, but they also play a crucial role in wound healing, orchestrating tissue repair. Recently, we demonstrated a significant accumulation of iron in healing wounds and a requireme... Read More about Tissue iron promotes wound repair via M2 macrophage polarisation and the chemokines CCL17 and CCL22.

The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects (2019)
Journal Article
Al-Qaissi, A., Alqarni, S., Javed, Z., Atkin, S. L., Sathyapalan, T., Vince, R., & Madden, L. A. (2019). The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects. Endocrine, https://doi.org/10.1007/s12020-019-02059-9

© 2019, The Author(s). Background: A retrospective analysis was carried out from patients and controls during the past 5 years from a series of studies investigating endothelial microparticles (MP). Methods: In total, 319 samples from 207 individuals... Read More about The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects.

Prevalence and incidence of atrial fibrillation in ambulatory patients with heart failure (2019)
Journal Article
Pellicori, P., Urbinati, A., Kaur, K., Zhang, J., Shah, P., Kazmi, S., …Clark, A. L. (2019). Prevalence and incidence of atrial fibrillation in ambulatory patients with heart failure. The American journal of cardiology, 124(10), 1554-1560. https://doi.org/10.1016/j.amjcard.2019.08.018

Heart failure (HF) and atrial fibrillation (AF) commonly co-exist. We aimed to determine the prevalence and incidence of AF in ambulatory patients with HF. HF was defined by the presence of symptoms or signs supported by objective evidence of cardiac... Read More about Prevalence and incidence of atrial fibrillation in ambulatory patients with heart failure.

Images depicting headache pain – a tool to aid the diagnosis of cluster headache: a pilot study (2019)
Journal Article
Buture, A., Boland, J. W., Ahmed, F., & Dikomitis, L. (2019). Images depicting headache pain – a tool to aid the diagnosis of cluster headache: a pilot study. Journal of Multidisciplinary Healthcare, 12, 691-698. https://doi.org/10.2147/JMDH.S207128

Introduction and objective: The diagnosis of primary headaches is based on the International Classification of Headache Disorders (ICHD-3). Cluster headache (CH), a debilitating primary headache, is often misdiagnosed as migraine. In the absence of b... Read More about Images depicting headache pain – a tool to aid the diagnosis of cluster headache: a pilot study.

Exercise training as a mediator for enhancing coronary collateral circulation: A review of the evidence (2019)
Journal Article
Nickolay, T., Nichols, S., Ingle, L., & Hoye, A. (2020). Exercise training as a mediator for enhancing coronary collateral circulation: A review of the evidence. Current Cardiology Reviews, 16(3), 212-220. https://doi.org/10.2174/1573403X15666190819144336

Coronary collateral vessels supply blood to areas of myocardium at risk after arterial occlusion. Flow through these channels is driven by a pressure gradient between the donor and the occluded artery. Concomitant with increased collateral flow is an... Read More about Exercise training as a mediator for enhancing coronary collateral circulation: A review of the evidence.

Mibefradil, a T-type Ca2+ channel blocker also blocks Orai channels by action at the extracellular surface (2019)
Journal Article
Li, P., Rubaiy, H. N., Chen, G.-L., Hallett, T., Zaibi, N., Zeng, B., Saurabh, R., & Xu, S.-Z. (2019). Mibefradil, a T-type Ca2+ channel blocker also blocks Orai channels by action at the extracellular surface. British Journal of Pharmacology, 176, 3845–3856. https://doi.org/10.1111/bph.14788

Background and purpose
Mibefradil (Mib), a T‐type Ca2+ channel blocker, has been investigated for treating solid tumours. However, its underlying mechanisms are still unclear. Here we aimed to investigate the pharmacological aspect of Mib on ORAI st... Read More about Mibefradil, a T-type Ca2+ channel blocker also blocks Orai channels by action at the extracellular surface.

The relationship between anthropometric measures and cardiometabolic health in shift work: findings from the Atlantic PATH Cohort Study (2019)
Journal Article
Sweeney, E., Yu, Z. M., Dummer, T. J. B., Cui, Y., DeClercq, V., Forbes, C., Grandy, S. A., Keats, M., Parker, L., & Adisesh, A. (2020). The relationship between anthropometric measures and cardiometabolic health in shift work: findings from the Atlantic PATH Cohort Study. International Archives of Occupational and Environmental Health, 93(1), 67-76. https://doi.org/10.1007/s00420-019-01459-8

Purpose: To evaluate the relationship between anthropometric measures and cardiometabolic health in shift workers compared to non-shift workers. Methods: A population health study was conducted with 4155 shift workers and 8258 non-shift workers from... Read More about The relationship between anthropometric measures and cardiometabolic health in shift work: findings from the Atlantic PATH Cohort Study.

High-sensitivity C-reactive protein in chronic heart failure: Patient characteristics, phenotypes, and mode of death (2019)
Journal Article
Pellicori, P., Zhang, J., Cuthbert, J., Urbinati, A., Shah, P., Kazmi, S., Clark, A. L., & Cleland, J. G. (2020). High-sensitivity C-reactive protein in chronic heart failure: Patient characteristics, phenotypes, and mode of death. Cardiovascular research, 116(1), 91-100. https://doi.org/10.1093/cvr/cvz198

Aims: Plasma concentrations of high-sensitivity C-reactive protein (hsCRP) are often raised in chronic heart failure (CHF) and might indicate inflammatory processes that could be a therapeutic target. We aimed to study the associations between hsCRP,... Read More about High-sensitivity C-reactive protein in chronic heart failure: Patient characteristics, phenotypes, and mode of death.

Atherogenic lipid stress induces platelet hyperactivity through CD36-mediated hyposensitivity to prostacyclin-; the role of phosphodiesterase 3A. (2019)
Journal Article
Berger, M., Raslan, Z., Aburima, A., Magwenzi, S., Wraith, K. S., Spurgeon, B. E., Hindle, M. S., Law, R., Febbraio, M., & Naseem, K. M. (2020). Atherogenic lipid stress induces platelet hyperactivity through CD36-mediated hyposensitivity to prostacyclin-; the role of phosphodiesterase 3A. Haematologica, 105(3), 808-819. https://doi.org/10.3324/haematol.2018.213348

©2020 Ferrata Storti Foundation Prostacyclin (PGI2) controls platelet activation and thrombosis through a cyclic adenosine monophosphate (cAMP) signaling cascade. However, in patients with cardiovascular diseases this protective mechanism fails for r... Read More about Atherogenic lipid stress induces platelet hyperactivity through CD36-mediated hyposensitivity to prostacyclin-; the role of phosphodiesterase 3A..

“Man in the driving seat”: A grounded theory study of the psychosocial experiences of Black African and Black Caribbean men treated for prostate cancer and their partners (2019)
Journal Article
Bamidele, O., McGarvey, H., Lagan, B. M., Parahoo, K., Chinegwundoh MBE, F., & McCaughan, E. (2019). “Man in the driving seat”: A grounded theory study of the psychosocial experiences of Black African and Black Caribbean men treated for prostate cancer and their partners. Psycho-oncology, 28(8), 1712-1720. https://doi.org/10.1002/pon.5150

Objective: Evidence suggests that treatment side‐effects of prostate cancer (CaP) substantially affect the psychosocial well‐being of affected men and their partners. However, this phenomenon is poorly understood among high risk (1 in 4) Black Africa... Read More about “Man in the driving seat”: A grounded theory study of the psychosocial experiences of Black African and Black Caribbean men treated for prostate cancer and their partners.

A systematic review of high-intensity interval training as an exercise intervention for intermittent claudication (2019)
Journal Article
Pymer, S., Palmer, J., Harwood, A. E., Ingle, L., Smith, G. E., & Chetter, I. C. (2019). A systematic review of high-intensity interval training as an exercise intervention for intermittent claudication. Journal of vascular surgery, https://doi.org/10.1016/j.jvs.2019.03.050

Background
Intermittent claudication (IC) is the most common symptom of peripheral arterial disease, which significantly affects walking ability, functional capacity and quality of life. Supervised exercise programs (SEP) are recommended as first-lin... Read More about A systematic review of high-intensity interval training as an exercise intervention for intermittent claudication.

The effect of atorvastatin (and subsequent metformin) on adipose tissue acylation-stimulatory-protein concentration and inflammatory biomarkers in overweight/obese women with polycystic ovary syndrome (2019)
Journal Article
Sathyapalan, T., Hobkirk, J. P., Javed, Z., Carroll, S., Coady, A. M., Pemberton, P., Smith, A., Cianflone, K., & Atkin, S. L. (2019). The effect of atorvastatin (and subsequent metformin) on adipose tissue acylation-stimulatory-protein concentration and inflammatory biomarkers in overweight/obese women with polycystic ovary syndrome. Frontiers in endocrinology, 10(JUN), Article 394. https://doi.org/10.3389/fendo.2019.00394

Copyright © 2019 Sathyapalan, Hobkirk, Javed, Carroll, Coady, Pemberton, Smith, Cianflone and Atkin. Background: Atorvastatin has been shown to improve cardiovascular risk (CVR) indices in women with polycystic ovary syndrome (PCOS). Low-grade chroni... Read More about The effect of atorvastatin (and subsequent metformin) on adipose tissue acylation-stimulatory-protein concentration and inflammatory biomarkers in overweight/obese women with polycystic ovary syndrome.