All Outputs (699)

Microsystems for personalized biomolecular diagnostics (2011)
Journal Article
Shaw, K. J., Birch, C., Hughes, E. M., Jakes, A. D., Greenman, J., & Haswell, S. J. (2011). Microsystems for personalized biomolecular diagnostics. Engineering in Life Sciences, 11(2), 121-132. https://doi.org/10.1002/elsc.201000175

The development of microfluidic methodology that can be used in conjunction with drug screening and biomolecular diagnostics offers a route to evidence-based personalized medical care. Ideally, all personal diagnostics are best carried out in a rapid... Read More about Microsystems for personalized biomolecular diagnostics.

Reply (2011)
Journal Article
Khan Mazari, F. A., & Chetter, I. C. (2011). Reply. Journal of vascular surgery, 53(4), 1164. https://doi.org/10.1016/j.jvs.2010.12.037

A pilot study to investigate the role of the 26S proteasome in radiotherapy resistance and loco-regional recurrence following breast conserving therapy for early breast cancer (2011)
Journal Article
ELFadl, D., Hodgkinson, V. C., Long, E. D., Scaife, L., Drew, P. J., Lind, M. J., & Cawkwell, L. (2011). A pilot study to investigate the role of the 26S proteasome in radiotherapy resistance and loco-regional recurrence following breast conserving therapy for early breast cancer. The Breast : official journal of the European Society of Mastology, 20(4), 334-337. https://doi.org/10.1016/j.breast.2011.02.017

Breast conserving therapy is a currently accepted method for managing patients with early stage breast cancer. However, approximately 7% of patients may develop loco-regional tumour recurrence within 5 years. We previously reported that expression of... Read More about A pilot study to investigate the role of the 26S proteasome in radiotherapy resistance and loco-regional recurrence following breast conserving therapy for early breast cancer.

Angiotensin converting enzyme inhibitors effect on endothelial dysfunction: a meta-analysis of randomised controlled trials (2011)
Journal Article
Shahin, Y., Khan, J. A., Samuel, N., & Chetter, I. (2011). Angiotensin converting enzyme inhibitors effect on endothelial dysfunction: a meta-analysis of randomised controlled trials. Atherosclerosis, 216(1), 7-16. https://doi.org/10.1016/j.atherosclerosis.2011.02.044

ObjectiveSeveral studies have assessed the effect of angiotensin converting enzyme inhibitors (ACEIs) on endothelial dysfunction as measured by brachial flow-mediated vasodilatation (FMD). We conducted a meta-analysis to investigate this effect in co... Read More about Angiotensin converting enzyme inhibitors effect on endothelial dysfunction: a meta-analysis of randomised controlled trials.

Repeatedly identified differentially expressed proteins (RIDEPs) from antibody microarray proteomic analysis (2011)
Journal Article
Hodgkinson, V. C., ELFadl, D., Drew, P. J., Lind, M. J., & Cawkwell, L. (2011). Repeatedly identified differentially expressed proteins (RIDEPs) from antibody microarray proteomic analysis. Journal of Proteomics, 74(5), 698-703. https://doi.org/10.1016/j.jprot.2011.02.014

Antibody microarrays are powerful new tools in the field of comparative proteomics. The success of the biomarker discovery pipeline relies on the quality of data generated in the discovery phase and careful selection of proteins for the verification... Read More about Repeatedly identified differentially expressed proteins (RIDEPs) from antibody microarray proteomic analysis.

Randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins (2011)
Journal Article
Carradice, D., Mekako, A. I., Mazari, F. A. K., Samuel, N., Hatfield, J., & Chetter, I. C. (2011). Randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins. British journal of surgery, 98(4), 501-510. https://doi.org/10.1002/bjs.7394

Background: Endovenous laser ablation (EVLA) is a popular minimally invasive treatment for varicose veins. Surgical treatment, featuring junctional ligation and inversion stripping, has shown excellent clinical and cost effectiveness. The clinical ef... Read More about Randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins.

Ultrasound evaluation of carotid body tumours (2011)
Journal Article
Samuel, N., Smith, G., Wolstenhulme, S., & Chetter, I. (2011). Ultrasound evaluation of carotid body tumours. Ultrasound, 19(1), 26-30. https://doi.org/10.1258/ult.2010.010037

Carotid body tumour (CBT) is a rare neoplasm that usually presents as an asymptomatic slow-growing neck mass at the carotid bifurcation. Due to these benign attributes, CBTs often go undiagnosed for a few years before a lateral neck mass becomes clin... Read More about Ultrasound evaluation of carotid body tumours.

Do angiotensin converting enzyme inhibitors improve walking distance in patients with symptomatic lower limb arterial disease? A systematic review and meta-analysis of randomised controlled trials (2010)
Journal Article
Shahin, Y., Mazari, F., & Chetter, I. (2011). Do angiotensin converting enzyme inhibitors improve walking distance in patients with symptomatic lower limb arterial disease? A systematic review and meta-analysis of randomised controlled trials. International journal of surgery, 9(3), 209-213. https://doi.org/10.1016/j.ijsu.2010.12.006

Background
Several studies have reported the clinical effects of long-term treatment with cardioprotective medications in patients with lower limb peripheral arterial disease (PAD) in terms of reducing cardiovascular morbidity and mortality. A numbe... Read More about Do angiotensin converting enzyme inhibitors improve walking distance in patients with symptomatic lower limb arterial disease? A systematic review and meta-analysis of randomised controlled trials.

Targeted epidermal growth factor receptor therapy in malignant pleural mesothelioma: where do we stand? (2010)
Journal Article
Agarwal, V., Lind, M. J., & Cawkwell, L. (2011). Targeted epidermal growth factor receptor therapy in malignant pleural mesothelioma: where do we stand?. Cancer Treatment Reviews, 37(7), 533-542. https://doi.org/10.1016/j.ctrv.2010.11.004

The median survival for patients with malignant pleural mesothelioma remains extremely poor and there is a need for the development of more effective treatment modalities. The epidermal growth factor receptor is frequently over-expressed in malignant... Read More about Targeted epidermal growth factor receptor therapy in malignant pleural mesothelioma: where do we stand?.

The national heart failure audit for England and Wales 2008-2009 (2010)
Journal Article
Yassin, A., Cleland, J., McDonagh, T., Rigby, A. S., Whittaker, T., Dargie, H. J., & on behalf of the National Heart Failure Audit Team for England and Wales. (2011). The national heart failure audit for England and Wales 2008-2009. Heart, 97(11), 876-886. https://doi.org/10.1136/hrt.2010.209171

Objectives To obtain national data on the clinical characteristics, investigation, management and outcome of patients hospitalised with a diagnosis of heart failure. Method A survey was carried out of the first 10 patients hospitalised with a primary... Read More about The national heart failure audit for England and Wales 2008-2009.

On Not Going Home at the End of the Day: Spatialised Discourses of Family Life in Single Location Home/Workplaces (2010)
Book Chapter
Seymour, J. (2010). On Not Going Home at the End of the Day: Spatialised Discourses of Family Life in Single Location Home/Workplaces. In Geographies of Children, Youth and Families: An International Perspective (108 - 120). Routledge

This chapter draws on a study of family practices in family-run hotels, pubs and discourse therefore „allows the researcher to map the doing of family life is revealed as a and boarding houses in the UK. One focus of the research is the spatiality of... Read More about On Not Going Home at the End of the Day: Spatialised Discourses of Family Life in Single Location Home/Workplaces.

Cough hypersensitivity syndrome: A distinct clinical entity (2010)
Journal Article
Morice, A. H., Faruqi, S., Wright, C. E., Thompson, R., & Bland, J. M. (2011). Cough hypersensitivity syndrome: A distinct clinical entity. Lung, 189(1), 73-79. https://doi.org/10.1007/s00408-010-9272-1

We postulate that most patients with chronic cough have a single discrete clinical entity: Cough Hypersensitivity Syndrome. We constructed a questionnaire that elicits the major components of the syndrome. Here we describe the validation of this ques... Read More about Cough hypersensitivity syndrome: A distinct clinical entity.

Recognition of inflammatory aneurysms in abdominal aortic aneurysm screening and surveillance (2010)
Journal Article
Smith, G. E., Samuel, N., Wolstenholme, S., Akomolafe, A. B., & Chetter, I. C. (2010). Recognition of inflammatory aneurysms in abdominal aortic aneurysm screening and surveillance. Ultrasound, 18(4), 186-190. https://doi.org/10.1258/ult.2010.010035

Inflammatory abdominal aortic aneurysms (IAAAs) account for 3-10% of all abdominal aortic aneurysms and are characterized by a thickened aneurysmal wall, with extensive fibrosis and adhesions. Ultrasound remains the investigation of choice for diagno... Read More about Recognition of inflammatory aneurysms in abdominal aortic aneurysm screening and surveillance.

Artificial neural networks to predict presence of significant pathology in patients presenting to routine colorectal clinics (2010)
Journal Article
Maslekar, S., Gardiner, A. B., Monson, J. R. T., & Duthie, G. S. (2010). Artificial neural networks to predict presence of significant pathology in patients presenting to routine colorectal clinics. Colorectal Disease, 12(12), 1254-1259. https://doi.org/10.1111/j.1463-1318.2009.02005.x

Aim Artificial neural networks (ANNs) are computer programs used to identify complex relations within data. Routine predictions of presence of colorectal pathology based on population statistics have little meaning for individual patient. This result... Read More about Artificial neural networks to predict presence of significant pathology in patients presenting to routine colorectal clinics.

Quantifying chronic cough: Objective versus subjective measurements (2010)
Journal Article
Faruqi, S., Thompson, R., Wright, C., Sheedy, W., & Morice, A. H. (2011). Quantifying chronic cough: Objective versus subjective measurements. Respirology : official journal of the Asian Pacific Society of Respirology, 16(2), 314-320. https://doi.org/10.1111/j.1440-1843.2010.01893.x

Background and objective: The assessment of chronic cough has been improved by the development of objective ambulatory cough monitoring systems and subjective quality of life questionnaires. Experimental induction of cough is a useful tool in the ass... Read More about Quantifying chronic cough: Objective versus subjective measurements.

Sorafenib enhances the in vitro anti-endothelial effects of low dose (metronomic) chemotherapy (2010)
Journal Article
Murray, A., Little, S. J., Stanley, P., Cawkwell, L., & Maraveyas, A. (2010). Sorafenib enhances the in vitro anti-endothelial effects of low dose (metronomic) chemotherapy. Oncology Reports, 24(4), 1049-1058. https://doi.org/10.3892/or-00000954

Angiogenesis inhibitors may enhance the effects of low dose (metronomic) chemotherapy. However, there is a wide range of novel angiogenesis inhibitors which must be tested in combinations with oral chemotherapy agents to assess the anti-endothelial a... Read More about Sorafenib enhances the in vitro anti-endothelial effects of low dose (metronomic) chemotherapy.

A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal ao (2010)
Journal Article
Rahman, M. A., Khan, J. A., Mazari, F. A. K., Mockford, K., McCollum, P. T., & Chetter, I. (2011). A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal ao. Annals of vascular surgery, 25(1), 32-38. https://doi.org/10.1016/j.avsg.2010.06.006

BackgroundA double-blind, randomized controlled trial was carried out to study the effects of statins on matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in areas of peak and low abdominal aortic aneurysm (A... Read More about A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal ao.

Computerized dynamic posturography in the objective assessment of balance in patients with intermittent claudication (2010)
Journal Article
Mockford, K. A., Mazari, F. A. K., Jordan, A. R., Vanicek, N., Chetter, I. C., & Coughlin, P. A. (2011). Computerized dynamic posturography in the objective assessment of balance in patients with intermittent claudication. Annals of vascular surgery, 25(2), 182-190. https://doi.org/10.1016/j.avsg.2010.07.021

One-third of all elderly patients fall each year and impaired balance has been recognized as a specific risk factor. Intermittent claudication is common among the elderly population, affecting approximately 5% of the population over the age of 50. Th... Read More about Computerized dynamic posturography in the objective assessment of balance in patients with intermittent claudication.

Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure (2010)
Journal Article
Shelton, R. J., Ingle, L., Rigby, A. S., Witte, K. K., Cleland, J. G., & Clark, A. L. (2010). Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure. European journal of heart failure, 12(9), 983-989. https://doi.org/10.1093/eurjhf/hfq086

Aims
Mechanisms of exercise limitation in patients with chronic heart failure (CHF) are incompletely understood. During matched submaximal, fixed-rate exercise, oxygen uptake is similar in patients and healthy controls. However, the importance of ca... Read More about Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure.

Hull early walking aid for rehabilitation of transtibial amputees - randomized controlled trial (HEART) (2010)
Journal Article
Mazari, F. A. K., Mockford, K., Vanicek, N., Barnett, C., Khan, J. A., Brown, B., Smith, L., Polman, R. C., Hancock, A., & Chetter, I. C. (2010). Hull early walking aid for rehabilitation of transtibial amputees - randomized controlled trial (HEART). Journal of vascular surgery, 52(6), 1564-1571. https://doi.org/10.1016/j.jvs.2010.07.006

Purpose: To compare articulated and nonarticulated early walking aids (EWAs) for clinical and quality-of-life outcomes in transtibial amputees. Methods: Patients undergoing lower limb amputation in a tertiary-care vascular surgical unit were screened... Read More about Hull early walking aid for rehabilitation of transtibial amputees - randomized controlled trial (HEART).