Microsystems for personalized biomolecular diagnostics

Shaw, Kirsty J.; Birch, Christopher; Hughes, Elizabeth M.; Jakes, Adam D.; Greenman, John; Haswell, Stephen J.

Abstract

The development of microfluidic methodology that can be used in conjunction with drug screening and biomolecular diagnostics offers a route to evidence-based personalized medical care. Ideally, all personal diagnostics are best carried out in a rapid and frequent manner and a microfluidic interface can provide appropriate methodology. The ability to perform genetic analysis or biomarker detection at point-of-care would allow the clinician to decide on the most informed course of treatment. Microfluidic systems for biomolecular analysis at all levels, from genes to whole tissue biopsies, have been proposed. Much of the work presented here is at an early stage of development but will consider the range of design considerations together with the plethora of potential applications of integrated microfluidic technology.

Citation

Shaw, K. J., Birch, C., Hughes, E. M., Jakes, A. D., Greenman, J., & Haswell, S. J. (2011). Microsystems for personalized biomolecular diagnostics. Engineering in Life Sciences, 11(2), 121-132. https://doi.org/10.1002/elsc.201000175

• Journal Article Type: Article
• Acceptance Date: Feb 18, 2011
• Online Publication Date: Apr 27, 2011
• Publication Date: 2011-04
• Journal: ENGINEERING IN LIFE SCIENCES
• Print ISSN: 1618-0240
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 2
• Pages: 121-132
• DOI: https://doi.org/10.1002/elsc.201000175
• Keywords: Diagnostics; Healthcare; Integration; Microfluidics; Personalized medicine
• Public URL: https://hull-repository.worktribe.com/output/396319
• Publisher URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/elsc.201000175