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Microsystems for personalized biomolecular diagnostics

Shaw, Kirsty J.; Birch, Christopher; Hughes, Elizabeth M.; Jakes, Adam D.; Greenman, John; Haswell, Stephen J.

Authors

Kirsty J. Shaw

Christopher Birch

Elizabeth M. Hughes

Adam D. Jakes

Stephen J. Haswell



Abstract

The development of microfluidic methodology that can be used in conjunction with drug screening and biomolecular diagnostics offers a route to evidence-based personalized medical care. Ideally, all personal diagnostics are best carried out in a rapid and frequent manner and a microfluidic interface can provide appropriate methodology. The ability to perform genetic analysis or biomarker detection at point-of-care would allow the clinician to decide on the most informed course of treatment. Microfluidic systems for biomolecular analysis at all levels, from genes to whole tissue biopsies, have been proposed. Much of the work presented here is at an early stage of development but will consider the range of design considerations together with the plethora of potential applications of integrated microfluidic technology.

Journal Article Type Article
Publication Date 2011-04
Journal ENGINEERING IN LIFE SCIENCES
Print ISSN 1618-0240
Electronic ISSN 1618-2863
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 11
Issue 2
Pages 121-132
APA6 Citation Shaw, K. J., Birch, C., Hughes, E. M., Jakes, A. D., Greenman, J., & Haswell, S. J. (2011). Microsystems for personalized biomolecular diagnostics. Engineering in Life Sciences, 11(2), 121-132. doi:10.1002/elsc.201000175
DOI https://doi.org/10.1002/elsc.201000175
Keywords Diagnostics; Healthcare; Integration; Microfluidics; Personalized medicine
Publisher URL https://onlinelibrary.wiley.com/doi/abs/10.1002/elsc.201000175