All Outputs (9)

Systematic Review and Meta-Analysis of Cardiovascular Consequences of Myocardial Bridging in Hypertrophic Cardiomyopathy (2022)
Journal Article
Bruce, C., Ubhi, N., McKeegan, P., & Sanders, K. (2023). Systematic Review and Meta-Analysis of Cardiovascular Consequences of Myocardial Bridging in Hypertrophic Cardiomyopathy. The American journal of cardiology, 188, P110-P119. https://doi.org/10.1016/j.amjcard.2022.10.059

Myocardial bridging (MB) is a congenital variant in which a segment of a coronary artery follows an atypical intramural course under a “bridge” of myocardium and is notably common in hypertrophic cardiomyopathy (HCM). This systematic review and meta-... Read More about Systematic Review and Meta-Analysis of Cardiovascular Consequences of Myocardial Bridging in Hypertrophic Cardiomyopathy.

Anatomy Nights: An international public engagement event increases audience knowledge of brain anatomy (2022)
Journal Article
Sanders, K. A., Philp, J. A., Jordan, C. Y., Cale, A. S., Cunningham, C. L., & Organ, J. M. (2022). Anatomy Nights: An international public engagement event increases audience knowledge of brain anatomy. PLoS ONE, 17(6 June), Article e0267550. https://doi.org/10.1371/journal.pone.0267550

Anatomy Nights is an international public engagement event created to bring anatomy and anatomists back to public spaces with the goal of increasing the public's understanding of their own anatomy by comparison with non-human tissues. The event consi... Read More about Anatomy Nights: An international public engagement event increases audience knowledge of brain anatomy.

Genome-wide DNA methylation changes in CD19+ B cells from relapsing-remitting multiple sclerosis patients (2018)
Journal Article
Maltby, V. E., Lea, R. A., Graves, M. C., Sanders, K. A., Benton, M. C., Tajouri, L., …Lechner-Scott, J. (2018). Genome-wide DNA methylation changes in CD19+ B cells from relapsing-remitting multiple sclerosis patients. Scientific reports, 8, Article 17418. https://doi.org/10.1038/s41598-018-35603-0

Multiple Sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system. The inflammatory process in MS is driven by both T and B cells and current therapies are targeted to each of these cell types. Epigenetic mechanis... Read More about Genome-wide DNA methylation changes in CD19+ B cells from relapsing-remitting multiple sclerosis patients.

DNA methylation changes in CD4+ T cells isolated from multiple sclerosis patients on dimethyl fumarate (2018)
Journal Article
Maltby, V. E., Lea, R. A., Ribbons, K. A., Sanders, K. A., Kennedy, D., Min, M., …Lechner-Scott, J. (2018). DNA methylation changes in CD4+ T cells isolated from multiple sclerosis patients on dimethyl fumarate. Multiple Sclerosis Journal - Experimental, Translational and Clinical, 4(3), https://doi.org/10.1177/2055217318787826

Background: Dimethyl fumarate is an oral treatment for multiple sclerosis, whose mechanism of action is not fully understood. Objective: To investigate the effects of dimethyl fumarate on DNA methylation in the CD4+ T cells of multiple sclerosis pati... Read More about DNA methylation changes in CD4+ T cells isolated from multiple sclerosis patients on dimethyl fumarate.

Erythrocyte microRNA sequencing reveals differential expression in relapsing-remitting multiple sclerosis (2018)
Journal Article
Groen, K., Maltby, V. E., Lea, R. A., Sanders, K. A., Fink, J. L., Scott, R. J., …Lechner-Scott, J. (2018). Erythrocyte microRNA sequencing reveals differential expression in relapsing-remitting multiple sclerosis. Journal Title BMC Medical Genomics, 11(1), Article 48. https://doi.org/10.1186/s12920-018-0365-7

Background: There is a paucity of knowledge concerning erythrocytes in the aetiology of Multiple Sclerosis (MS) despite their potential to contribute to disease through impaired antioxidant capacity and altered haemorheological features. Several stud... Read More about Erythrocyte microRNA sequencing reveals differential expression in relapsing-remitting multiple sclerosis.

Differential methylation at MHC in CD4+ T cells is associated with multiple sclerosis independently of HLA-DRB1 (2017)
Journal Article
Maltby, V. E., Lea, R. A., Sanders, K. A., White, N., Benton, M. C., Scott, R. J., & Lechner-Scott, J. (2017). Differential methylation at MHC in CD4+ T cells is associated with multiple sclerosis independently of HLA-DRB1. Clinical epigenetics, 9(1), Article 71. https://doi.org/10.1186/s13148-017-0371-1

Background: Although many genetic variants have been associated with multiple sclerosis (MS) risk, they do not explain all the disease risk and there remains uncertainty as to how these variants contribute to disease. DNA methylation is an epigenetic... Read More about Differential methylation at MHC in CD4+ T cells is associated with multiple sclerosis independently of HLA-DRB1.

Next-generation sequencing reveals broad down-regulation of microRNAs in secondary progressive multiple sclerosis CD4+ T cells (2016)
Journal Article
Sanders, K. A., Benton, M. C., Lea, R. A., Maltby, V. E., Agland, S., Griffin, N., …Lechner-Scott, J. (2016). Next-generation sequencing reveals broad down-regulation of microRNAs in secondary progressive multiple sclerosis CD4+ T cells. Clinical epigenetics, 8(1), Article 87. https://doi.org/10.1186/s13148-016-0253-y

Background: Immunoactivation is less evident in secondary progressive MS (SPMS) compared to relapsing-remitting disease. MicroRNA (miRNA) expression is integral to the regulation of gene expression; determining their impact on immune-related cell fun... Read More about Next-generation sequencing reveals broad down-regulation of microRNAs in secondary progressive multiple sclerosis CD4+ T cells.

Genome-wide DNA methylation profiling of CD8+ T cells shows a distinct epigenetic signature to CD4+ T cells in multiple sclerosis patients (2015)
Journal Article
Maltby, V. E., Graves, M. C., Lea, R. A., Benton, M. C., Sanders, K. A., Tajouri, L., …Lechner-Scott, J. (2015). Genome-wide DNA methylation profiling of CD8+ T cells shows a distinct epigenetic signature to CD4+ T cells in multiple sclerosis patients. Clinical epigenetics, 7(1), Article 118. https://doi.org/10.1186/s13148-015-0152-7

Background: Multiple sclerosis (MS) is thought to be a T cell-mediated autoimmune disorder. MS pathogenesis is likely due to a genetic predisposition triggered by a variety of environmental factors. Epigenetics, particularly DNA methylation, provide... Read More about Genome-wide DNA methylation profiling of CD8+ T cells shows a distinct epigenetic signature to CD4+ T cells in multiple sclerosis patients.

Polymeric nanofibrous substrates stimulate pluripotent stem cells to form three-dimensional multilayered patty-like spheroids in feeder-free culture and maintain their pluripotency (2014)
Journal Article
Alamein, M. A., Wolvetang, E. J., Ovchinnikov, D. A., Stephens, S., Sanders, K., & Warnke, P. H. (2015). Polymeric nanofibrous substrates stimulate pluripotent stem cells to form three-dimensional multilayered patty-like spheroids in feeder-free culture and maintain their pluripotency. Journal of tissue engineering and regenerative medicine, 9(9), 1078-1083. https://doi.org/10.1002/term.1960

Expansion of pluripotent stem cells in defined media devoid of animal-derived feeder cells to generate multilayered three-dimensional (3D) bulk preparations or spheroids, rather than two-dimensional (2D) monolayers, is advantageous for many regenerat... Read More about Polymeric nanofibrous substrates stimulate pluripotent stem cells to form three-dimensional multilayered patty-like spheroids in feeder-free culture and maintain their pluripotency.