Skip to main content

Research Repository

Advanced Search

All Outputs (48)

An Exploration of Factors Affecting Timely Referral of Patients with Chronic Limb-Threatening Ischaemia (2025)
Thesis
Atkins, E. (2025). An Exploration of Factors Affecting Timely Referral of Patients with Chronic Limb-Threatening Ischaemia. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/5130250

Chronic limb-threatening ischaemia (CLTI) is the end-stage of peripheral arterial disease. It is associated with significant risks of limb loss and mortality, which increase with delays to revascularisation. There is currently little understanding of... Read More about An Exploration of Factors Affecting Timely Referral of Patients with Chronic Limb-Threatening Ischaemia.

Interventions to improve the quality of life in patients living with endocrine conditions A (2025)
Thesis
Ssemmondo, E. (2025). Interventions to improve the quality of life in patients living with endocrine conditions A. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/5006299

Introduction
Patients living with chronic endocrine conditions experience a burden of disease which affects their quality of life compared to healthy controls. In people living with type 1 and type 2 diabetes, this may be due to micro or macrovascul... Read More about Interventions to improve the quality of life in patients living with endocrine conditions A.

Investigation of Aged Human Lung Endothelial Cells in Idiopathic Pulmonary Fibrosis (2024)
Thesis
Faulkner, E. C. Investigation of Aged Human Lung Endothelial Cells in Idiopathic Pulmonary Fibrosis. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4866422

Introduction
Older age is the main risk factor for idiopathic pulmonary fibrosis (IPF). Ageing-related changes in lung blood (pulmonary and bronchial) and lymphatic vessels are implicated in IPF pathophysiology, based on reports of their altered den... Read More about Investigation of Aged Human Lung Endothelial Cells in Idiopathic Pulmonary Fibrosis.

Parenteral nutrition and venting gastrostomy in the management of malignant bowel obstruction (2024)
Thesis
Patterson, M. J. Parenteral nutrition and venting gastrostomy in the management of malignant bowel obstruction. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4711450

Background: Malignant bowel obstruction (MBO) is a distressing complication of gastrointestinal, gynaecological and other cancers causing severe pain, intractable nausea and vomiting, anorexia, and death. There are no agreed best approaches for sympt... Read More about Parenteral nutrition and venting gastrostomy in the management of malignant bowel obstruction.

Identification of tumour anitgens that may facilitate effective cancer detection and treatment (2024)
Thesis
Mohamed, E. Identification of tumour anitgens that may facilitate effective cancer detection and treatment. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4866442

Tumour antigens (TAs) play a crucial role in terms of cancer diagnosis and targets for therapy. As TAs are normally expressed in restricted tissues such as testis, sensitivity and specificity may not be ideal, but they could still represent good biom... Read More about Identification of tumour anitgens that may facilitate effective cancer detection and treatment.

Addressing delays to treatment in patients with chronic limb-threatening ischaemia (2023)
Thesis
Birmpili, P. Addressing delays to treatment in patients with chronic limb-threatening ischaemia. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4371299

Patients with CLTI often face long delays from referral to the vascular surgery service and hospital admission to revascularisation, and there is limited evidence on the effect of these delays on patient outcomes. This thesis aims to identify factors... Read More about Addressing delays to treatment in patients with chronic limb-threatening ischaemia.

Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells (2023)
Thesis
Haque, F. Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4371279

The premalignant pancreatic cellular genotype can remain stable for years before rapid malignant transformation, often associated with inflammation. Tissue factor (TF) is an inflammatory modulator regulated by factor VIIa (fVIIa) for its levels and a... Read More about Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells.

Age-Associated Changes in Voltage-Gated Sodium Channels Within the Right Atrium Predispose the Elderly to Atrial Fibrillation (2022)
Thesis
Isaac, E. S. Age-Associated Changes in Voltage-Gated Sodium Channels Within the Right Atrium Predispose the Elderly to Atrial Fibrillation. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4508137

Atrial Fibrillation (AF) is the most common cardiac arrhythmia worldwide with sufferers of the condition facing significant morbidity and mortality. Ageing alone is identified as the most significant risk factor for developing the arrhythmia. As such... Read More about Age-Associated Changes in Voltage-Gated Sodium Channels Within the Right Atrium Predispose the Elderly to Atrial Fibrillation.

Determination of epithelial growth factor receptor mutations in circulatory tumour cells from non-small cell lung cancer patients isolated using a novel microfluidic device (2022)
Thesis
Ogidi, N. O. Determination of epithelial growth factor receptor mutations in circulatory tumour cells from non-small cell lung cancer patients isolated using a novel microfluidic device. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4270004

Patients with epidermal growth factor receptor (EGFR) sensitizing mutations in non small cell lung cancer (NSCLC) receive benefit from Tyrosine Kinase inhibitors. Accurate selection of patients before treatment is highly dependent on precise molecula... Read More about Determination of epithelial growth factor receptor mutations in circulatory tumour cells from non-small cell lung cancer patients isolated using a novel microfluidic device.

The detection and assessment of malnutrition, sarcopenia and cachexia, in older adults with cancer (2022)
Thesis
Bullock, A. F. The detection and assessment of malnutrition, sarcopenia and cachexia, in older adults with cancer. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4484119

Background: Older adults with cancer are a complex and growing population requiring tailored care to achieve optimum treatment outcomes. However, their care is complicated by underrecognised
and under-treated nutrition-related wasting disorders: mal... Read More about The detection and assessment of malnutrition, sarcopenia and cachexia, in older adults with cancer.

Effects of the pharmacological interventions and a structured education in the management of polycystic ovary syndrome (PCOS) (2022)
Thesis
Abdalla, M. A. Effects of the pharmacological interventions and a structured education in the management of polycystic ovary syndrome (PCOS). (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4224300

Introduction
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder that affects women of reproductive age and is associated with an array of metabolic disorders. Insulin resistance, increased body weight, dyslipidaemia and excess an... Read More about Effects of the pharmacological interventions and a structured education in the management of polycystic ovary syndrome (PCOS).

Developing an evidence-based system to facilitate the predictive assessment and optimisation of older adults with cancer (2021)
Thesis
McKenzie, G. A. G. Developing an evidence-based system to facilitate the predictive assessment and optimisation of older adults with cancer. (Thesis). The University of Hull and the University of York. https://hull-repository.worktribe.com/output/4192792

Introduction: Older adults with cancer have worse outcomes than their younger counterparts, including higher postoperative complications, chemotherapy toxicity and treatment allocation to best supportive care. Oncogeriatric assessment (OGA) can provi... Read More about Developing an evidence-based system to facilitate the predictive assessment and optimisation of older adults with cancer.

Mechanochemical ablation in the treatment of superficial venous incompetence (2021)
Thesis
Mohamed, A. Mechanochemical ablation in the treatment of superficial venous incompetence. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4223528

Background
The routine management of venous incompetence has undergone considerable changes in the last two decades led by the introduction of minimally invasive endovenous techniques. At the heart of these changes has been a drive to offer patients... Read More about Mechanochemical ablation in the treatment of superficial venous incompetence.

Entering a new era of surgical training : developing 3-dimensional print models for hands-on surgical training and its introduction into the congenital cardiac surgical curriculum (2021)
Thesis
Hussein, N. Entering a new era of surgical training : developing 3-dimensional print models for hands-on surgical training and its introduction into the congenital cardiac surgical curriculum. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4223672

Congenital heart surgery is a technically challenging subspecialty of cardiothoracic surgery. This is due to a combination of factors including the rarity and variety of pathology and the small patient size. This coupled with the increasing public sc... Read More about Entering a new era of surgical training : developing 3-dimensional print models for hands-on surgical training and its introduction into the congenital cardiac surgical curriculum.

Alternative exercise programmes for the treatment of intermittent claudication - from unsupervised home-based walking to supervised high-intensity interval cycling (2021)
Thesis
Pymer, S. Alternative exercise programmes for the treatment of intermittent claudication - from unsupervised home-based walking to supervised high-intensity interval cycling. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4223166

Supervised exercise programmes (SEP) for intermittent claudication (IC) suffer from low provision and uptake rates. As such, alternative interventions should be explored, such as home-based exercise programmes (HEP) and high-intensity interval traini... Read More about Alternative exercise programmes for the treatment of intermittent claudication - from unsupervised home-based walking to supervised high-intensity interval cycling.

Association of Differing Qatari Genotypes with Vitamin D Metabolites (2020)
Thesis
Dakroury, Y. Association of Differing Qatari Genotypes with Vitamin D Metabolites. (Thesis). Hull York Medical School, The University of Hull and The University of York. https://hull-repository.worktribe.com/output/4192858

This work aimed to determine the possible association between Qatari genotypes and vitamin-D deficiency and diabetes complications. Through next-generation exome sequencing three major genetic Qatari genotypes were determined, Q1 - Bedouin, Q2 - Pers... Read More about Association of Differing Qatari Genotypes with Vitamin D Metabolites.

A study of clinicopathological characteristics, symptoms and patients experiences related to outcomes in people with cancer and I-PE (2019)
Thesis
Benelhaj, N. E. A study of clinicopathological characteristics, symptoms and patients experiences related to outcomes in people with cancer and I-PE. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4222310

Background: The clinical course of incidental pulmonary embolism in cancer population represents an area of controversy. It presents a growing challenge for clinicians because of a lack of prospective data.

Aim: This research aims to investigate t... Read More about A study of clinicopathological characteristics, symptoms and patients experiences related to outcomes in people with cancer and I-PE.

Investigating the effectiveness of dialkylcarbamoylchloride-coated wound dressings in the prevention of surgical site infection (2019)
Thesis
Totty, J. P. Investigating the effectiveness of dialkylcarbamoylchloride-coated wound dressings in the prevention of surgical site infection. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4222026

Background: Surgical site infection (SSI) is the second most common healthcare acquired infection and may complicate between 5 and 30% of all surgical procedures. Avoidance of antibiotic or antimicrobial agents is important to future prevention strat... Read More about Investigating the effectiveness of dialkylcarbamoylchloride-coated wound dressings in the prevention of surgical site infection.

Myocardial energy metabolism in patients undergoing cardiac surgery (2018)
Thesis
Haqzad, Y. S. Myocardial energy metabolism in patients undergoing cardiac surgery. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4221969

In chapter 1, short and long term outcomes were assessed in diabetic phenotypes. The phenotypes have been propensity matched for factors that significantly contribute to outcomes. Tablet controlled diabetics have worse short and long term outcomes co... Read More about Myocardial energy metabolism in patients undergoing cardiac surgery.