All Outputs (1207)

Evaluating trastuzumab in the treatment of HER2 positive breast cancer (2020)
Journal Article
Jaques, R., Xu, S., & Matsakas, A. (2020). Evaluating trastuzumab in the treatment of HER2 positive breast cancer. Histology and Histopathology, 35(10), 1059-1075. https://doi.org/10.14670/HH-18-221

© 2020, Histology and Histopathology. All rights reserved. The transmembrane oncoprotein HER2 is encoded by ERBB2 gene and overexpressed in around 20% of invasive breast cancers. It can be specifically targeted by Trastuzumab (Herceptin®), a humanise... Read More about Evaluating trastuzumab in the treatment of HER2 positive breast cancer.

Understanding the shared experiences of creating a digital life story with individuals with dementia and their spouse (2020)
Journal Article
Sweeney, L., Wolverson, E., & Clarke, C. (2021). Understanding the shared experiences of creating a digital life story with individuals with dementia and their spouse. Dementia, 20(5), 1791–1813. https://doi.org/10.1177/1471301220970403

Introduction
Life story books in dementia are used as a part of person-centred care. Whilst the current literature demonstrates associations between completing life story books and increased well-being, little is known about the process and how it i... Read More about Understanding the shared experiences of creating a digital life story with individuals with dementia and their spouse.

Tellurium in Late Permian-Early Triassic Sediments as a Proxy for Siberian Flood Basalt Volcanism (2020)
Journal Article
Regelous, M., Regelous, A., Grasby, S. E., Bond, D. P., Haase, K. M., Gleißner, S., & Wignall, P. B. (2020). Tellurium in Late Permian-Early Triassic Sediments as a Proxy for Siberian Flood Basalt Volcanism. Geochemistry, geophysics, geosystems G³, 21(11), Article e2020GC009064. https://doi.org/10.1029/2020GC009064

We measured the concentrations of trace elements in Late Permian to Early Triassic sediments from Spitsbergen. High mercury concentrations in sediments from the level of the Permo-Triassic Mass Extinction (PTME) at this location were previously attri... Read More about Tellurium in Late Permian-Early Triassic Sediments as a Proxy for Siberian Flood Basalt Volcanism.

Surgical fixation compared with cast immobilisation for adults with a bicortical fracture of the scaphoid waist: the SWIFFT RCT (2020)
Journal Article
Dias, J., Brealey, S., Cook, L., Fairhurst, C., Hinde, S., Leighton, P., Choudary, S., Costa, M., Hewitt, C., Hodgson, S., Jefferson, L., Jeyapalan, K., Keding, A., Northgraves, M., Palmer, J., Rangan, A., Richardson, G., Taub, N., Tew, G., Thompson, J., & Torgerson, D. (2020). Surgical fixation compared with cast immobilisation for adults with a bicortical fracture of the scaphoid waist: the SWIFFT RCT. Health Technology Assessment, 24(52), 1-234. https://doi.org/10.3310/hta24520

Participants: Adults (aged ≥ 16 years) presenting within 2 weeks of injury with a clear, bicortical fracture of the scaphoid waist on plain radiographs. Interventions: Early surgical fixation using Conformité Européenne-marked headless compression sc... Read More about Surgical fixation compared with cast immobilisation for adults with a bicortical fracture of the scaphoid waist: the SWIFFT RCT.

Hourly performance forecast of a dew point cooler using explainable Artificial Intelligence and evolutionary optimisations by 2050 (2020)
Journal Article
Golizadeh Akhlaghi, Y., Aslansefat, K., Zhao, X., Sadati, S., Badiei, A., Xiao, X., Shittu, S., Fan, Y., & Ma, X. (2021). Hourly performance forecast of a dew point cooler using explainable Artificial Intelligence and evolutionary optimisations by 2050. Applied energy, 281, Article 116062. https://doi.org/10.1016/j.apenergy.2020.116062

The empirical success of the Artificial Intelligence (AI), has enhanced importance of the transparency in black box Machine Learning (ML) models. This study pioneers in developing an explainable and interpretable Deep Neural Network (DNN) model for a... Read More about Hourly performance forecast of a dew point cooler using explainable Artificial Intelligence and evolutionary optimisations by 2050.

Do early warning track and trigger tools improve patient outcomes? A systematic synthesis without meta-analysis (2020)
Journal Article
Credland, N., Dyson, J., & Johnson, M. J. (in press). Do early warning track and trigger tools improve patient outcomes? A systematic synthesis without meta-analysis. Journal of advanced nursing, https://doi.org/10.1111/jan.14619

Aim
To determine the effect of Early Warning Track and Trigger Tools on patient outcomes.

Design
A systematic review: synthesis without meta‐analysis.

Data sources
Electronic databases were searched from 1 January 2013–1 August 2018 and 221... Read More about Do early warning track and trigger tools improve patient outcomes? A systematic synthesis without meta-analysis.

Active Withernsea Deep Dive Report to Sport England: Inequalities Impacting on Physical Activity, and Policies to Mitigate or Prevent those Inequalities (2020)
Report
Powell, L., & Midgley, G. (2020). Active Withernsea Deep Dive Report to Sport England: Inequalities Impacting on Physical Activity, and Policies to Mitigate or Prevent those Inequalities. Sport England and East Riding of Yorkshire Council

Inorganic fouling of heat transfer surface from potable water during convective heat transfer (2020)
Journal Article
Al-Gailani, A., Sanni, O., Charpentier, T. V., Crisp, R., Bruins, J. H., & Neville, A. (2021). Inorganic fouling of heat transfer surface from potable water during convective heat transfer. Applied thermal engineering, 184, Article 116271. https://doi.org/10.1016/j.applthermaleng.2020.116271

In this work, inorganic fouling of the heat transfer surfaces from potable water has been studied using a once-through flow cell to visualize and follow the deposition processes. The effects of surface material and flow rate on the amount and morphol... Read More about Inorganic fouling of heat transfer surface from potable water during convective heat transfer.

The Kasei Valles, Mars: a unified record of episodic channel flows and ancient ocean levels (2020)
Journal Article
Duran, S., & Coulthard, T. J. (2020). The Kasei Valles, Mars: a unified record of episodic channel flows and ancient ocean levels. Scientific reports, 10(1), Article 18571. https://doi.org/10.1038/s41598-020-75080-y

There is widespread evidence across Mars of past flows in major channel systems as well as more than one palaeo ocean level. However, evidence for the timing of channel flows and ocean levels is based on geographically diverse sources with a limited... Read More about The Kasei Valles, Mars: a unified record of episodic channel flows and ancient ocean levels.

Targeted and passive environmental DNA approaches outperform established methods for detection of quagga mussels, Dreissena rostriformis bugensis in flowing water (2020)
Journal Article
Blackman, R. C., Ling, K. K. S., Harper, L. R., Shum, P., Hänfling, B., & Lawson-Handley, L. (2020). Targeted and passive environmental DNA approaches outperform established methods for detection of quagga mussels, Dreissena rostriformis bugensis in flowing water. Ecology and Evolution, https://doi.org/10.1002/ece3.6921

The early detection of invasive non-native species (INNS) is important for informing management actions. Established monitoring methods require the collection or observation of specimens, which is unlikely at the beginning of an invasion when densiti... Read More about Targeted and passive environmental DNA approaches outperform established methods for detection of quagga mussels, Dreissena rostriformis bugensis in flowing water.

Perceptions and experiences of laws and regulations governing access to opioids in South, Southeast, East and Central Asia: A systematic review, critical interpretative synthesis and development of a conceptual framework (2020)
Journal Article
Clark, J., Gnanapragasam, S., Greenley, S., Pearce, J., & Johnson, M. (in press). Perceptions and experiences of laws and regulations governing access to opioids in South, Southeast, East and Central Asia: A systematic review, critical interpretative synthesis and development of a conceptual framework. Palliative medicine, https://doi.org/10.1177/0269216320966505

© The Author(s) 2020. Background: Opioids are essential medicines. Despite international and national laws permitting availability, opioid access remains inadequate, particularly in South, Southeast, East and Central Asia. Aim: To review evidence of... Read More about Perceptions and experiences of laws and regulations governing access to opioids in South, Southeast, East and Central Asia: A systematic review, critical interpretative synthesis and development of a conceptual framework.

Impact of Minimum Unit Pricing on Alcohol-Related Emergency Department Attendances in Scotland: A Natural Experiment Study (2020)
Preprint / Working Paper
So, V., Millard, A. D., Katikireddi, S. V., Deluca, P., Drummond, C., Eadie, D., Fitzgerald, N., Ford, A., Forsyth, R., Graham, L., Hilton, S., Ludbrook, A., McCartney, G., Molaodi, O., Open, M., Owens, L., Perry, S., Phillips, T., Stead, M., Yap, C., …Leyland, A. H. Impact of Minimum Unit Pricing on Alcohol-Related Emergency Department Attendances in Scotland: A Natural Experiment Study

Background: Minimum Unit Pricing (MUP) was introduced in Scotland at 50p per unit (8g) of alcohol on 1st May 2018 to reduce alcohol consumption and associated harms. We assessed its impact on alcohol-related emergency department (ED) attendances, dri... Read More about Impact of Minimum Unit Pricing on Alcohol-Related Emergency Department Attendances in Scotland: A Natural Experiment Study.

GASP XXIX-unwinding the arms of spiral galaxies via ram-pressure stripping (2020)
Journal Article
Bellhouse, C., McGee, S. L., Smith, R., Poggianti, B. M., Jaffé, Y. L., Kraljic, K., Franchetto, A., Fritz, J., Vulcani, B., Tonnesen, S., Roediger, E., Moretti, A., Gullieuszik, M., & Shin, J. (2020). GASP XXIX-unwinding the arms of spiral galaxies via ram-pressure stripping. Monthly notices of the Royal Astronomical Society, 500(1), 1285-1312. https://doi.org/10.1093/mnras/staa3298

We present the first study of the effect of ram pressure ‘unwinding’ the spiral arms of cluster galaxies. We study 11 ram-pressure stripped galaxies from GASP (GAs Stripping Phenomena in galaxies) in which, in addition to more commonly observed ‘jell... Read More about GASP XXIX-unwinding the arms of spiral galaxies via ram-pressure stripping.

The forensic exploitation of fingermark chemistry: A review (2020)
Journal Article
Bleay, S. M., Bailey, M. J., Croxton, R. S., & Francese, S. (in press). The forensic exploitation of fingermark chemistry: A review. WIREs Forensic Science, Article e1403. https://doi.org/10.1002/wfs2.1403

The substances deposited from the fingertip onto a surface during contact between them represent a highly complex range of chemicals that can be exploited in a variety of ways in a forensic investigation. An overview is given of the multitude of chem... Read More about The forensic exploitation of fingermark chemistry: A review.

Recent advances in drug discovery for diabetic kidney disease (2020)
Journal Article
Danta, C. C., Boa, A. N., Bhandari, S., Sathyapalan, T., & Xu, S. Z. (2021). Recent advances in drug discovery for diabetic kidney disease. Expert Opinion on Drug Discovery, 16(4), 447-461. https://doi.org/10.1080/17460441.2021.1832077

Introduction: Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease (ESRD), and 40% of patients with diabetes develop DKD. Although some pathophysiological mechanisms and drug targets of DKD have been described, the effectivenes... Read More about Recent advances in drug discovery for diabetic kidney disease.

Old ways and new fears bayanihan and covid-19 (2020)
Journal Article
Bankoff, G. (2020). Old ways and new fears bayanihan and covid-19. Philippine studies, historical & ethnographic viewpoints, 68(3-4), 467-475

© Ateneo de Manila University. In times of trouble, Filipinos traditionally turn to one another for help. This form of community assistance is popularly known as bayanihan. Historically, Filipinos have met the challenges of life in their perilous hom... Read More about Old ways and new fears bayanihan and covid-19.

Exam Preparation: Concerns of London Upper Secondary School Students with Implications for Teachers and Teaching (2020)
Journal Article
Minott, M. A. (2020). Exam Preparation: Concerns of London Upper Secondary School Students with Implications for Teachers and Teaching. Journal of Educational Research and Practice, 10(1), 338-350. https://doi.org/10.5590/jerap.2020.10.1.21

The aim of this qualitative case study was to ascertain factors impacting the examination preparation process and causing concerns for London upper secondary students, to learn steps taken to reduce and/or resolve the concerns, and to discuss the imp... Read More about Exam Preparation: Concerns of London Upper Secondary School Students with Implications for Teachers and Teaching.

An age-associated reduction in Nav1.5 protein expression correlates with an increase in Nav1.8 protein expression in the right atrial appendage of the human heart. (2020)
Presentation / Conference Contribution
Isaac, E., Cooper, S., Lancaster, M., Loubani, M., & Jones, S. An age-associated reduction in Nav1.5 protein expression correlates with an increase in Nav1.8 protein expression in the right atrial appendage of the human heart. Presented at Basic Cardiovascular Sciences Scientific Sessions 2020, Online

Background: Nav1.5 is the predominantly expressed voltage-gated sodium channel (VGSC) isoform in the heart, responsible for phase 0 of the action potential. Our rodent studies have shown expression of neuronal isoform Nav1.8 protein in the adult hear... Read More about An age-associated reduction in Nav1.5 protein expression correlates with an increase in Nav1.8 protein expression in the right atrial appendage of the human heart..

Coordination and collaboration for humanitarian operational excellence : big data and modern information processing systems (2020)
Journal Article
Akhtar, P., Osburg, V.-S., Kabra, G., Ullah, S., Shabbir, H., & Kumari, S. (in press). Coordination and collaboration for humanitarian operational excellence : big data and modern information processing systems. Production planning & control, https://doi.org/10.1080/09537287.2020.1834126

Humanitarian operational excellence depends on effective coordination and collaboration not only between supply chain partners but also among other actors such as host government, local and international non-government organizations (NGOs), and donor... Read More about Coordination and collaboration for humanitarian operational excellence : big data and modern information processing systems.

Transcriptomic analysis of age-associated periventricular lesions reveals dysregulation of the immune response (2020)
Journal Article
Fadul, M. M., Heath, P. R., Cooper-Knock, J., Kurz, J. M., Al-Azzawi, H. A., Ali, Z., Smith, T., Matthews, F. E., Brayne, C., Wharton, S. B., & Simpson, J. E. (2020). Transcriptomic analysis of age-associated periventricular lesions reveals dysregulation of the immune response. International Journal of Molecular Sciences, 21(21), Article 7924. https://doi.org/10.3390/ijms21217924

White matter lesions (WML) are a common feature of the ageing brain associated with cognitive impairment. The gene expression profiles of periventricular lesions (PVL, n = 7) and radiologically-normal-appearing (control) periventricular white matter... Read More about Transcriptomic analysis of age-associated periventricular lesions reveals dysregulation of the immune response.