All Outputs (10)

Bioproduction of Linalool From Paper Mill Waste (2022)
Journal Article
Rinaldi, M. A., Tait, S., Toogood, H. S., & Scrutton, N. S. (2022). Bioproduction of Linalool From Paper Mill Waste. Frontiers in Bioengineering and Biotechnology, 10, Article 892896. https://doi.org/10.3389/fbioe.2022.892896

A key challenge in chemicals biomanufacturing is the maintenance of stable, highly productive microbial strains to enable cost-effective fermentation at scale. A “cookie-cutter” approach to microbial engineering is often used to optimize host stabili... Read More about Bioproduction of Linalool From Paper Mill Waste.

Alternative metabolic pathways and strategies to high-titre terpenoid production in: Escherichia coli (2022)
Journal Article
Rinaldi, M. A., Ferraz, C. A., & Scrutton, N. S. (2022). Alternative metabolic pathways and strategies to high-titre terpenoid production in: Escherichia coli. Natural Product Reports, 39(1), 90-118. https://doi.org/10.1039/d1np00025j

Covering: up to 2021 Terpenoids are a diverse group of chemicals used in a wide range of industries. Microbial terpenoid production has the potential to displace traditional manufacturing of these compounds with renewable processes, but further titre... Read More about Alternative metabolic pathways and strategies to high-titre terpenoid production in: Escherichia coli.

Flavonoid Versus Artemisinin Anti-malarial Activity in Artemisia annua Whole-Leaf Extracts (2019)
Journal Article
Czechowski, T., Rinaldi, M. A., Famodimu, M. T., Van Veelen, M., Larson, T. R., Winzer, T., …Graham, I. A. (2019). Flavonoid Versus Artemisinin Anti-malarial Activity in Artemisia annua Whole-Leaf Extracts. Frontiers in Plant Science, 10, Article 984. https://doi.org/10.3389/fpls.2019.00984

Artemisinin, a sesquiterpene lactone produced by Artemisia annua glandular secretory trichomes, is the active ingredient in the most effective treatment for uncomplicated malaria caused by Plasmodium falciparum parasites. Other metabolites in A. annu... Read More about Flavonoid Versus Artemisinin Anti-malarial Activity in Artemisia annua Whole-Leaf Extracts.

The PEX1 ATPase stabilizes PEX6 and plays essential roles in peroxisome biology (2017)
Journal Article
Rinaldi, M. A., Fleming, W. A., Gonzalez, K. L., Park, J., Ventura, M. J., Patel, A. B., & Bartel, B. (2017). The PEX1 ATPase stabilizes PEX6 and plays essential roles in peroxisome biology. Plant Physiology, 174(4), 2231-2247. https://doi.org/10.1104/pp.17.00548

A variety of metabolic pathways are sequestered in peroxisomes, conserved organelles that are essential for human and plant survival. Peroxin (PEX) proteins generate and maintain peroxisomes. The PEX1 ATPase facilitates recycling of the peroxisome ma... Read More about The PEX1 ATPase stabilizes PEX6 and plays essential roles in peroxisome biology.

The roles of β-oxidation and cofactor homeostasis in peroxisome distribution and function in Arabidopsis thaliana (2016)
Journal Article
Rinaldi, M. A., Patel, A. B., Park, J., Lee, K., Strader, L. C., & Bartel, B. (2016). The roles of β-oxidation and cofactor homeostasis in peroxisome distribution and function in Arabidopsis thaliana. Genetics, 204(3), 1089-1115. https://doi.org/10.1534/genetics.116.193169

Key steps of essential metabolic pathways are housed in plant peroxisomes. We conducted a microscopy-based screen for anomalous distribution of peroxisomally targeted fluorescence in Arabidopsis thaliana. This screen uncovered 34 novel alleles in 15... Read More about The roles of β-oxidation and cofactor homeostasis in peroxisome distribution and function in Arabidopsis thaliana.

Mutation of the Arabidopsis LON2 peroxisomal protease enhances pexophagy (2014)
Journal Article
Bartel, B., Farmer, L. M., Rinaldi, M. A., Young, P. G., Danan, C. H., & Burkhart, S. E. (2014). Mutation of the Arabidopsis LON2 peroxisomal protease enhances pexophagy. Autophagy, 10(3), 518-519. https://doi.org/10.4161/auto.27565

Peroxisomes are critical organelles housing various, often oxidative, reactions. Pexophagy, the process by which peroxisomes are selectively targeted for destruction via autophagy, is characterized in yeast and mammals but had not been reported in pl... Read More about Mutation of the Arabidopsis LON2 peroxisomal protease enhances pexophagy.

Disrupting autophagy restores peroxisome function to an arabidopsis lon2 mutant and reveals a role for the LON2 protease in peroxisomal matrix protein degradation (2013)
Journal Article
Farmer, L. M., Rinaldi, M. A., Young, P. G., Danan, C. H., Burkhart, S. E., & Bartel, B. (2013). Disrupting autophagy restores peroxisome function to an arabidopsis lon2 mutant and reveals a role for the LON2 protease in peroxisomal matrix protein degradation. The Plant Cell, 25(10), 4085-4100. https://doi.org/10.1105/tpc.113.113407

Peroxisomes house critical metabolic reactions that are essential for seedling development. As seedlings mature, metabolic requirements change, and peroxisomal contents are remodeled. The resident peroxisomal protease LON2 is positioned to degrade ob... Read More about Disrupting autophagy restores peroxisome function to an arabidopsis lon2 mutant and reveals a role for the LON2 protease in peroxisomal matrix protein degradation.

The cytochrome b5 dependent C-5(6) sterol desaturase DES5A from the endoplasmic reticulum of Tetrahymena thermophila complements ergosterol biosynthesis mutants in Saccharomyces cerevisiae (2012)
Journal Article
Poklepovich, T. J., Rinaldi, M. A., Tomazic, M. L., Favale, N. O., Turkewitz, A. P., Nudel, C. B., & Nusblat, A. D. (2012). The cytochrome b5 dependent C-5(6) sterol desaturase DES5A from the endoplasmic reticulum of Tetrahymena thermophila complements ergosterol biosynthesis mutants in Saccharomyces cerevisiae. Steroids, 77(13), 1313-1320. https://doi.org/10.1016/j.steroids.2012.08.015

Tetrahymena thermophila is a free-living ciliate with no exogenous sterol requirement. However, it can perform several modifications on externally added sterols including desaturation at C5(6), C7(8), and C22(23). Sterol desaturases in Tetrahymena ar... Read More about The cytochrome b5 dependent C-5(6) sterol desaturase DES5A from the endoplasmic reticulum of Tetrahymena thermophila complements ergosterol biosynthesis mutants in Saccharomyces cerevisiae.

A gain-of-function mutation in IAA16 confers reduced responses to auxin and abscisic acid and impedes plant growth and fertility (2012)
Journal Article
Rinaldi, M. A., Liu, J., Enders, T. A., Bartel, B., & Strader, L. C. (2012). A gain-of-function mutation in IAA16 confers reduced responses to auxin and abscisic acid and impedes plant growth and fertility. Plant Molecular Biology, 79(4-5), 359-373. https://doi.org/10.1007/s11103-012-9917-y

Auxin regulates many aspects of plant development, in part, through degradation of the Aux/IAA family of transcriptional repressors. Consequently, stabilizing mutations in several Aux/IAA proteins confer reduced auxin responsiveness. However, of the... Read More about A gain-of-function mutation in IAA16 confers reduced responses to auxin and abscisic acid and impedes plant growth and fertility.

Incentive or habit learning in amphibians? (2011)
Journal Article
Muzio, R. N., Pistone Creydt, V., Iurman, M., Rinaldi, M. A., Sirani, B., & Papini, M. R. (2011). Incentive or habit learning in amphibians?. PLoS ONE, 6(11), Article e25798. https://doi.org/10.1371/journal.pone.0025798

Toads (Rhinella arenarum) received training with a novel incentive procedure involving access to solutions of different NaCl concentrations. In Experiment 1, instrumental behavior and weight variation data confirmed that such solutions yield incentiv... Read More about Incentive or habit learning in amphibians?.