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Relationship between stair ascent gait speed, bone density and gait characteristics of postmenopausal women (2023)
Journal Article
Dostan, A., Dobson, C. A., & Vanicek, N. (2023). Relationship between stair ascent gait speed, bone density and gait characteristics of postmenopausal women. PLoS ONE, 18(3), Article e0283333. https://doi.org/10.1371/journal.pone.0283333

Stair ascent is a biomechanically challenging task for older women. Bone health may affect gait stability during stair walking. This study investigated the gait biomechanics associated with stair ascent in a group of postmenopausal women in relation... Read More about Relationship between stair ascent gait speed, bone density and gait characteristics of postmenopausal women.

Modeling and control of anterior–posterior and medial–lateral sways in standing posture (2022)
Journal Article
Hou, M., Fagan, M., Vanicek, N., & Dobson, C. A. (2022). Modeling and control of anterior–posterior and medial–lateral sways in standing posture. Journal of biomechanics, 134, Article 110930. https://doi.org/10.1016/j.jbiomech.2021.110930

To study essential anterior–posterior and medial–lateral sways of the stance caused by rotational movements about the ankle and hip joints, a mathematical model is developed for the 3D postural kinematics and dynamics. The model is in the form of non... Read More about Modeling and control of anterior–posterior and medial–lateral sways in standing posture.

The influence of musculoskeletal forces on the growth of the prenatal cortex in the ilium: a finite element study (2020)
Journal Article
Watson, P. J., Fagan, M. J., & Dobson, C. A. (in press). The influence of musculoskeletal forces on the growth of the prenatal cortex in the ilium: a finite element study. Computer methods in biomechanics and biomedical engineering, https://doi.org/10.1080/10255842.2020.1777546

Remodelling and adaptation of bone within the pelvis is believed to be influenced by the mechanical strains generated during locomotion. Variation in the cortical bone thickness observed in the prenatal ilium has been linked to the musculoskeletal lo... Read More about The influence of musculoskeletal forces on the growth of the prenatal cortex in the ilium: a finite element study.

A 12-month continuous and intermittent high-impact exercise intervention and its effects on bone mineral density in early postmenopausal women: A feasibility randomized controlled trial (2020)
Journal Article
Montgomery, G. . J. H., Abt, G., Dobson, C. A., Evans, W. J., Aye, M., & Ditroilo, M. (2020). A 12-month continuous and intermittent high-impact exercise intervention and its effects on bone mineral density in early postmenopausal women: A feasibility randomized controlled trial. Journal of Sports Medicine and Physical Fitness, 60(5), 770-778. https://doi.org/10.23736/S0022-4707.20.10412-2

BACKGROUND: Intermittent mechanical loading generates greater bone adaptations than continuous mechanical loading in rodents but has never been evaluated in humans. This study aimed to evaluate the feasibility of a continuous and intermittent counter... Read More about A 12-month continuous and intermittent high-impact exercise intervention and its effects on bone mineral density in early postmenopausal women: A feasibility randomized controlled trial.

The mechanical loading and muscle activation of four common exercises used in osteoporosis prevention for early postmenopausal women (2018)
Journal Article
Montgomery, G., Abt, G., Dobson, C., Smith, T., Evans, W., & Ditroilo, M. (2019). The mechanical loading and muscle activation of four common exercises used in osteoporosis prevention for early postmenopausal women. Journal of Electromyography and Kinesiology, 44, 124-131. https://doi.org/10.1016/j.jelekin.2018.12.004

High impact exercise can reduce postmenopausal bone loss, however stimulus frequency (loading cycles per second) can affect osteogenesis. We aimed to examine the effect of stimulus frequency on the mechanical loading of four common osteoporosis preve... Read More about The mechanical loading and muscle activation of four common exercises used in osteoporosis prevention for early postmenopausal women.

Relationships between walking speed, T-score and age with gait parameters in older post-menopausal women with low bone mineral density (2018)
Journal Article
Dostanpor, A., Dobson, C. A., & Vanicek, N. (2018). Relationships between walking speed, T-score and age with gait parameters in older post-menopausal women with low bone mineral density. Gait and Posture, 64, 230-237. https://doi.org/10.1016/j.gaitpost.2018.05.005

Background: The gait patterns of women with low bone mineral density (BMD) or osteoporosis have not been thoroughly explored, and when examined, often studied in relation to falls and kyphosis. Research question: The aim of this study was to investig... Read More about Relationships between walking speed, T-score and age with gait parameters in older post-menopausal women with low bone mineral density.

The potential role of variations in juvenile hip geometry on the development of Legg-Calvé-Perthes disease: a biomechanical investigation (2018)
Journal Article
Pinheiro, M. D. S., Dobson, C., Clarke, N. M., & Fagan, M. (2018). The potential role of variations in juvenile hip geometry on the development of Legg-Calvé-Perthes disease: a biomechanical investigation. Computer methods in biomechanics and biomedical engineering, 21(2), 194-200. https://doi.org/10.1080/10255842.2018.1437151

© 2018 Informa UK Limited, trading as Taylor & Francis Group Legg-Calvé-Perthes disease (LCP) is one of the most poorly understood diseases in paediatric orthopaedics. One common trait of LCP is the marked morphological difference between healthy a... Read More about The potential role of variations in juvenile hip geometry on the development of Legg-Calvé-Perthes disease: a biomechanical investigation.

New insights into the biomechanics of Legg-Calvé-Perthes’ disease: The role of epiphyseal skeletal immaturity in vascular obstruction (2018)
Journal Article
Pinheiro, M., Dobson, C. A., Perry, D., & Fagan, M. J. (2018). New insights into the biomechanics of Legg-Calvé-Perthes’ disease: The role of epiphyseal skeletal immaturity in vascular obstruction. Bone & joint research, 7(2), 148-156. https://doi.org/10.1302/2046-3758.72.bjr-2017-0191.r1

Objectives
Legg–Calvé–Perthes’ disease (LCP) is an idiopathic osteonecrosis of the femoral head that is most common in children between four and eight years old. The factors that lead to the onset of LCP are still unclear; however, it is believed th... Read More about New insights into the biomechanics of Legg-Calvé-Perthes’ disease: The role of epiphyseal skeletal immaturity in vascular obstruction.

The effect of boundary constraints on finite element modelling of the human pelvis (2017)
Journal Article
Watson, P., Dostanpor, A., Fagan, M. J., & Dobson, C. A. (2017). The effect of boundary constraints on finite element modelling of the human pelvis. Medical engineering & physics, 43, 48-57. https://doi.org/10.1016/j.medengphy.2017.02.001

The use of finite element analysis (FEA) to investigate the biomechanics of anatomical systems critically relies on the specification of physiologically representative boundary conditions. The biomechanics of the pelvis has been the specific focus of... Read More about The effect of boundary constraints on finite element modelling of the human pelvis.

Tibial impacts and muscle activation during walking, jogging and running when performed overground, and on motorised and non-motorised treadmills (2016)
Journal Article
Montgomery, G., Abt, G., Dobson, C., Smith, T., & Ditroilo, M. (2016). Tibial impacts and muscle activation during walking, jogging and running when performed overground, and on motorised and non-motorised treadmills. Gait and Posture, 49, 120-126. https://doi.org/10.1016/j.gaitpost.2016.06.037

Purpose To examine tibial acceleration and muscle activation during overground (OG), motorised treadmill (MT) and non-motorised treadmill conditions (NMT) when walking, jogging and running at matched velocities. Methods An accelerometer recorded acce... Read More about Tibial impacts and muscle activation during walking, jogging and running when performed overground, and on motorised and non-motorised treadmills.

Skeletal immaturity, rostral sparing, and disparate hip morphologies as biomechanical causes for Legg-Calvé-Perthes’ disease (2016)
Journal Article
Berthaume, M. A., Perry, D. C., Dobson, C. A., Witzel, U., Clarke, N. M., & Fagan, M. J. (2016). Skeletal immaturity, rostral sparing, and disparate hip morphologies as biomechanical causes for Legg-Calvé-Perthes’ disease. Clinical Anatomy, 29(6), 759-772. https://doi.org/10.1002/ca.22690

Legg-Calvé-Perthes' (Perthes') disease is a developmental disease of the hip joint that may result in numerous short and long term problems. The etiology of the disease remains largely unknown, but the mechanism is believed to be vascular and/or biom... Read More about Skeletal immaturity, rostral sparing, and disparate hip morphologies as biomechanical causes for Legg-Calvé-Perthes’ disease.

Sensitivity to model geometry in finite element analyses of reconstructed skeletal structures: Experience with a juvenile pelvis (2014)
Journal Article
Watson, P. J., Fagan, M. J., & Dobson, C. A. (2015). Sensitivity to model geometry in finite element analyses of reconstructed skeletal structures: Experience with a juvenile pelvis. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 229(1), 9-19. https://doi.org/10.1177/0954411914564476

Biomechanical analysis of juvenile pelvic growth can be used in the evaluation of medical devices and investigation of hip joint disorders. This requires access to scan data of healthy juveniles, which are not always freely available. This article an... Read More about Sensitivity to model geometry in finite element analyses of reconstructed skeletal structures: Experience with a juvenile pelvis.

Validation of a morphometric reconstruction technique applied to a juvenile pelvis (2010)
Journal Article
Watson, P., O'Higgins, P., Fagan, M. J., & Dobson, C. A. (2011). Validation of a morphometric reconstruction technique applied to a juvenile pelvis. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 225(1), 48-57. https://doi.org/10.1243/09544119jeim810

Three-dimensional reconstructions of bone geometry from microCT (computed tomography) data are frequently used in biomechanical and finite element analyses. Digitization of bone models is usually a simple process for specimens with a complete geometr... Read More about Validation of a morphometric reconstruction technique applied to a juvenile pelvis.

Masticatory loading and bone adaptation in the supraorbital torus of developing macaques (2008)
Journal Article
Kupczik, K., Dobson, C. A., Crompton, R. H., Phillips, R., Oxnard, C. E., Fagan, M. J., & O'Higgins, P. (2009). Masticatory loading and bone adaptation in the supraorbital torus of developing macaques. American journal of physical anthropology, 139(2), 193-203. https://doi.org/10.1002/ajpa.20972

Research on the evolution and adaptive significance of primate craniofacial morphologies has focused on adult, fully developed individuals. Here, we investigate the possible relationship between the local stress environment arising from masticatory l... Read More about Masticatory loading and bone adaptation in the supraorbital torus of developing macaques.

Assessing mechanical function of the zygomatic region in macaques: validation and sensitivity testing of finite element models (2006)
Journal Article
Kupczik, K., Dobson, C. A., Fagan, M. J., Crompton, R. H., Oxnard, C. E., & O'Higgins, P. (2007). Assessing mechanical function of the zygomatic region in macaques: validation and sensitivity testing of finite element models. Journal of anatomy, 210(1), 41-53. https://doi.org/10.1111/j.1469-7580.2006.00662.x

Crucial to the interpretation of the results of any finite element analysis of a skeletal system is a test of the validity of the results and an assessment of the sensitivity of the model parameters. We have therefore developed finite element models... Read More about Assessing mechanical function of the zygomatic region in macaques: validation and sensitivity testing of finite element models.

Three dimensional stereolithography models of cancellous bone structures from μCT data: Testing and validation of finite element results (2006)
Journal Article
Dobson, C. A., Sisias, G., Phillips, R., Langton, C. M., & Fagan, M. J. (2006). Three dimensional stereolithography models of cancellous bone structures from μCT data: Testing and validation of finite element results. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 220(3), 481-484. https://doi.org/10.1243/09544119H00405

Stereolithography (STL) models of complex cancellous bone structures have been produced from three-dimensional micro-computed tomography data sets of human cancellous bone histological samples from four skeletal sites. The STL models have been mechan... Read More about Three dimensional stereolithography models of cancellous bone structures from μCT data: Testing and validation of finite element results.

Stereo visualization of 3D trabecular bone structures produced by bone remodelling simulation (2003)
Presentation / Conference Contribution
Phillips, R., Grunchec, J. A., Ward, J. W., Fagan, M. J., Dobson, C. A., Langton, C. M., & Sisias, G. Stereo visualization of 3D trabecular bone structures produced by bone remodelling simulation

Adult human bone is constantly being renewed by a process known as remodelling. For cancellous bone this renewal process occurs at the interface between bone and marrow where bone is depleted by osteoclasts and rebuilt by osteoblasts. This remodellin... Read More about Stereo visualization of 3D trabecular bone structures produced by bone remodelling simulation.