Professor John Greenman
| Post Nominals | BSc (Hons) PhD |
|---|---|
| Biography | John is a tumour immunologist with extensive experience of developing lab on a chip technology for analysing tumour biopsies. He has published more than 200 peer-reviewed publications and his interdisciplinary immunobiology group works closely with clinicians, chemists and biomedical engineers. His research work has focused on Glioblastoma and tumours of the head and neck region, identifying novel markers of progression or treatment response. He has supervised successfully more than 100 postgraduate students (PhD, MD and MSc by Thesis) during his time in Hull. 1991-1995 Post-doctoral Research Fellow, Sir William Dunn School of Pathology, MRC Cellular Immunology Unit, University of Oxford 1995-1999 Lecturer in Immunology, Dept of Surgery, University of Hull 1999-2004 Senior Lecturer in Tumour Immunology 2004- 2009 Reader in Tumour Immunology 2009 - to date Prof of Tumour Immunology REF2014 - Appointed as Output Assessor for Panel UoA3 (2014) REF2020 - UoA3 Panel member |
| Research Interests | Coming from an immunology background, Professor Greenman is extremely interested in understanding how the immune system is often subverted during carcinogenesis, and more importantly how such knowledge can be used clinically (diagnostically, prognostically or therapeutically). Current and recent grants Breast Cancer UK £199,108 (Wade and Greenman) The role of endocrine disrupting chemicals on extracellular vesicle release and breast carcinogenesis. Sep 2025 – Aug 2027. Help for Health (£150,000) Six MSc Research studentships (Greenman). Nov 2022 – Sep 2026. T Cypher Bio (£16,000). Characterization of cancer specific T cells identified from head and neck cancer patient samples (Greenman). July 2023 – June 2027. Brignall Charitable Trust (£75,000). Detection of novel biomarkers for identifying thyroid tumours using novel microfluidic technology (Greenman and Green) Nov 2022 – Oct 2025. NERC Discipline Hopping award £13,582 (Beltran-Alvarez, Joyce, Greenman) Fish on chips: developing a new microfluidics model as a tool for testing and mitigating the effects of environmental and biological contaminants on fish. 12/2022 – 04/2023 Development of point-of-care and wearable sensors for Hepatitis C diagnostics. £75,000 (Ibrahim, Walter, Greenman) British Council Studentship 09/2020 – 08/2023. Coalition for Epidemic Preparedness Innovations (CEPI) £439,828 (Greenman, Green – collaboration with UK-HSA and Quadram) SARS-CoV-2 Variant Assessment in Microphysiological Systems (VAMPS) SO11 04/2022 – end 11/2025 Brain Research UK £109, 580 (Marsh – student, Wade, Greenman) The epigenetic regulatory protein CBX2 as a novel therapeutic target for glioblastoma 09/2022 – 09/2025 Commercial. £294,000 (Greenman and Green), Investigating the effect of novel bispecifics targeting immunostimulatory molecules to target human tumour tissue using Hull's tissue-on-chip ex vivo platform 01/04/2022 – 311/03/2023 (with year extension agreed) H2020-MSCA-RISE-2016, €976,000 (€153k to Hull) (Greenman). Blood test for clinical therapy guidance of non-small cell lung cancer patients. Yorkshire Cancer Research, €99,198 (Lind and Greenman). Peripheral blood detection of EGFR status in lung cancer patients. 01/11/2016 - 31/10/2018 Innovate UK/EPSRC €496,000 (€193k to Hull) (Greenman, Green, Cawthorne). Development of a multi-purpose small animal phantom for pre-clinical radiotherapy studies. 01/03/2016 - 28/02/2018. |
| Teaching and Learning | BSc programmes - Microbiology and Immunology (Level 4) - Clinical Microbiology and Immunology (Level 5) - Professional and Research skills for Biomedical Sciences (Level 5) - Canc er biology (Level 6) - Final Year Research Projects (Level 6) MSc programmes - Tumour Immunology and Microenvironment - Research Project and Dissertation |
| Scopus Author ID | 57197936420 |
| PhD Supervision Availability | Yes |
| PhD Topics | I welcome applications to work with me in either the biomedical applications of microfluidic devices or head and neck immunobiology. These can come from basic scientists or medically trained individuals. Completed PhDs 104 postgraduate (PhD, MD and MSc (Research)) students successfully supervised since 1999. PhD Cheah, R. (2016), Monitoring the Response of Head and Neck Tumour Tissue to Irradiation Using a Microfluidic-Based Approach Smith, J. (2016), The Effect of HNSCC-derived Soluble Factors on the Proliferation and Function of Immune Cells Chandrabalan, K. (2016), A Microfluidic Approach to the Study of Cellular Responses to Oxidative Stress Williamson, J. (2016), The Role of Endothelial Adhesins in Leukocyte Adhesion in Response to Pharmaceutical Agents that Induce Pulmonary Fibrosis Todd, A. (2016), Role of Hypoxia-Induced Adam 10 in Colorectal Cancer Progression Pacelli, A. (2015), Development of a Pet Probe for the Imaging of Cox-2 Expression in Cancers MD Patel, R. (2016), An Observational Pilot Study to Assess the Potential of a Microfluidic Tissue Culture Model to Predict Rectal Cancer Response to Neo-Adjuvant Therapy Zahoor, T. (2016), Does HPV-16 Seropositivity Correlate with T-cell Distribution Providing Additional Prognostic Information in Infected HNSCC Patients? Carr, S. (2013), Assessing the Effects of Radiotherapy on Head and Neck Squamous Cell Carcinoma using Microfluidic Techniques Current PhD supervisors Currently acting as primary and secondary supervisor to 6 postgraduate students covering all aspects of my research interests. |