Professor John Greenman's Projects (31)

Help 4 Health MSc studentships (2nd tranche) Feb 15, 2025 - Feb 1, 2027
Help 4 Health, through a competitive review process agreed to fund 3 MSc students (covering fees, a stipend of £16,062, and approximately £4k towards consumables).

Identification of circulating miRNA biomarkers in thyroid disease Jul 1, 2024 - Jun 30, 2025
Background: Currently, calcitonin, thyroglobulin and thyroid stimulating hormone receptor antibodies (TSH-R-Ab) can help monitor thyroid cancer post-operatively, however, these cannot distinguish between benign and malignant neoplasms, or between dif... Read More about Identification of circulating miRNA biomarkers in thyroid disease.

Fully humanised model of ageing endothelium to study ageing-associated lung diseases: Apr 1, 2024 - Jan 1, 2025

Wolfson Equipment bid 2023 - Confocal Imaging ZEISS Elyra 7 with Lattice SIM² Oct 1, 2024 - Sep 30, 2029

NERC Discipline Hopping: Fish on chips: developing a new microfluidics model as a tool for testing and mitigating the effects of environmental and biological contaminants on fish Dec 1, 2022 - Mar 31, 2023

Detection of novel biomarkers for identifying thyroid tumours using novel microfluidic technology - Brignall Trust Nov 1, 2022 - Oct 31, 2025
This PhD studentship was awarded by the Brignall Trust - PhD attached.
The funding is held by Alumni & Development- CRCJ29
The PhD student started in September 2022

Help 4 Health MSc studentships Nov 1, 2022 - Feb 29, 2024
Help 4 Health, through a competitive review process agreed to fund 3 MSc students (covering fees, a stipend of £16,062, and approximately £4k towards consumables).

Support for the Thyroid Cancer Research team Oct 1, 2022 - Jul 31, 2024
Support for the Thyroid Cancer Research team.

RISE: Establishing super-Resolution Imaging in Hull for impactful multimorbidity ReSEarch MRC Equipment bid 2024 - Confocal Imaging ZEISS Elyra 7 with Lattice SIM² Oct 1, 2024 - Sep 30, 2029

UKRI Covid 19 Extension Pot - Global analysis of molecular changes in head and neck squamous cell carcinoma (HNSCC) tissue maintained and treated on microfluidic devices Jul 1, 2020 - Sep 30, 2021
The technician employed (0.5 FTE) on the grant started work at the Daisy Laboratories, Castle Hill Hospital, on 2nd March 2020 and was trained on all of the techniques necessary. However, due to the onset of Covid-19 only one tumour sample was obtai... Read More about UKRI Covid 19 Extension Pot - Global analysis of molecular changes in head and neck squamous cell carcinoma (HNSCC) tissue maintained and treated on microfluidic devices.

The epigenetic regulatory protein CBX2 as a novel therapeutic target for glioblastoma multiform Sep 19, 2022 - Sep 18, 2025
PhD Studentship:

Glioblastoma (GBM) is the deadliest form of brain tumour, affecting 2-3 per 100,000 people each year. The average length of survival for GBM remain low at only 12-15 months following diagnosis, in part, due to a lack of targeted t... Read More about The epigenetic regulatory protein CBX2 as a novel therapeutic target for glioblastoma multiform.

Identification of exosomal miRNA biomarkers in thyroid disease using microfluidics Jan 3, 2022 - Aug 31, 2023
Invasive tissue biopsies remain the gold standard for diagnosis of diseases within solid tissues. However, for some diseases, accessibility of the tissue prevents a diagnostic biopsy and for those that are sampled, the biopsy only takes a small frac... Read More about Identification of exosomal miRNA biomarkers in thyroid disease using microfluidics.

Identification of exosomal miRNA biomarkers in thyroid disease using microfluidics Sep 1, 2021 - Aug 31, 2022
Invasive tissue biopsies remain the gold standard for diagnosis of diseases within solid tissues. However, for some diseases, accessibility of the tissue prevents a diagnostic biopsy and for those that are sampled, the biopsy only takes a small frac... Read More about Identification of exosomal miRNA biomarkers in thyroid disease using microfluidics.

Exploiting microfluidic technology to predict chemoradiation responses in HNSCC May 31, 2022 - Nov 30, 2023
Head and neck cancer (HNC) is the 6th most prevalent cancer worldwide. The mainstay of treatment involves a combination of radiation and cisplatin. Despite improvements in the delivery of these treatments, and enhanced guided radiotherapy, 3yr surv... Read More about Exploiting microfluidic technology to predict chemoradiation responses in HNSCC.

Development of an in-vitro model for Parkinson's disease Jan 1, 2020 - Dec 31, 2021
Parkinson’s disease affects 6.1 million people globally. The number of cases has more than doubled in the last 15 years and this cannot fully be attributed to an increase in life expectancy. The social and economic costs are in excess of £3 billion a... Read More about Development of an in-vitro model for Parkinson's disease.

Global analysis of molecular changes in head and neck squamous cell carcinoma (HNSCC) tissue maintained and treated on microfluidic devices Feb 1, 2020 - Sep 30, 2021
We have developed a microfluidic platform in which small pieces of human tissue from tumours are maintained in an in vivo-like state. These laboratory-maintained samples appear to respond to treatment in the same way as patients do clinically, but th... Read More about Global analysis of molecular changes in head and neck squamous cell carcinoma (HNSCC) tissue maintained and treated on microfluidic devices.

Development of point-of-care and wearable sensors for Hepatitis C diagnostics Sep 1, 2020 - Aug 31, 2023
PhD studentship application for full PhD studentship as part of Netwon Mosharafa Fund, allows for £25k per annum for registration and bench fees.

Monitoring the secretome of advanced thyroid cancers for metastatic markers May 20, 2019 - Sep 18, 2019
Aim
To identify potential biomarkers of thyroid cancer aggressiveness and metastasis.

Background
Despite differentiated thyroid cancer (DTC) typically presenting as a localised and highly treatable disease with an excellent 10-year survival rate... Read More about Monitoring the secretome of advanced thyroid cancers for metastatic markers.

Utilising tissue-on-a-chip technology as an ex vivo model of breast cancer metastatic colonisation Jul 1, 2019 - Mar 31, 2021
Breast cancer kills over 11,000 women each year in the UK. Virtually all of these women die because their breast cancer cells travel to other organs within the body such as the liver, lungs, bones and brain, where they grow into new tumours and stop... Read More about Utilising tissue-on-a-chip technology as an ex vivo model of breast cancer metastatic colonisation.

Development of an immune-responsive 3D skin model May 1, 2019 - Jul 31, 2019
The immune system is an essential regulator of normal physiologic and wound repair processes within the skin, and it contributes to the progression of many different skin diseases. The nature of the interactions between circulating immune cells and r... Read More about Development of an immune-responsive 3D skin model.

Evaluating EV as a therapeutic target in Graves’ disease Feb 1, 2019 - Dec 31, 2020
Evaluating EV as a therapeutic target in Graves’ disease

Graves’ disease is an autoimmune disease characterised by elevated circulating autoantibodies to the thyrotropin receptor (TRAB), resulting in hyperthyroidism. Inflammation, characteristic o... Read More about Evaluating EV as a therapeutic target in Graves’ disease.

Understanding cardiac failure in patients with chronic kidney disease Aug 1, 2018 - Jan 31, 2019
As previously shown Chronic Kidney Disease (CKD) patients have additional cardiovascular risk associated with increased mortality. Uraemic Cardiomyopathy (UCM) a frequent finding in CKD contributes to the poor clinical outcomes. Prof Bhandair and col... Read More about Understanding cardiac failure in patients with chronic kidney disease.

Investigation of immunological response to chemoradiation, using checkpoint inhibitors, in rectal tumours Jan 1, 2019 - Dec 31, 2026
The plan is for Hull to partner with a colleague in Glasgow (Dr Campbell Roxborough) and to pool resources. Both are aiming to recruit 40 patients with locally-advanced, non-metastatic rectal cancer who are deemed suitable by an authorised colorectal... Read More about Investigation of immunological response to chemoradiation, using checkpoint inhibitors, in rectal tumours.

Development of fully humanised animal free models to study the role of endothelial cells in chronic diseases. Jul 2, 2018 - Aug 28, 2018
Endothelial cells play important roles within the human body. They line blood and lymphatic vessels and regulate the work of cardiovascular and lymphatic systems. The faulty function of endothelial cells often contributes to the development of life-t... Read More about Development of fully humanised animal free models to study the role of endothelial cells in chronic diseases..

An evaluation of the CAMS - Collaborative Assessment and Management of Suicidality Apr 1, 2018 - Mar 31, 2021
This study will conduct the first evaluation of the psychosocial impact of a new therapeutic framework (Collaborative Assessment and Management of Suicidality - CAMS) on patients and clinicians in the National Health Service (NHS). CAMS, developed in... Read More about An evaluation of the CAMS - Collaborative Assessment and Management of Suicidality.

In vitro analysis of thyroid cancer and it's response to radiotherapy May 22, 2015 - May 21, 2018

The effect of corticosteroids on the release of immune modulating factors from Graves’ disease tissue maintained using microfluidic culture. Jun 1, 2017 - May 31, 2018
Graves’ disease (GD) affects approximately 2% of adult women. Current treatments for GD include anti-thyroid drugs, radioiodine therapy and surgery, of which none tackle the underlying pathogenic process. Immunosuppressive agents are therefore of gro... Read More about The effect of corticosteroids on the release of immune modulating factors from Graves’ disease tissue maintained using microfluidic culture..

Development of a multipurpose small animal phantom for pre-clinical radiotherapy studies Apr 1, 2016 - Mar 31, 2019
The project aims to both reduce the total number of animals used for preclinical radiotherapy experiments whilst concurrently increasing the accuracy of such investigations in order to maximise their clinical impact. This will be achieved through the... Read More about Development of a multipurpose small animal phantom for pre-clinical radiotherapy studies.

The Hull-Norwich Gut-Brian Study May 31, 2016 - Jun 30, 2018
Objective To obtain mechanistic insights into how resident commensal gut bacteria (the microbiota) influences host physiology and in particular brain function and host behaviour. The focus is on identifying the pathways and molecules originating from... Read More about The Hull-Norwich Gut-Brian Study.

Blood test for clinical therapy guidance of non-small cell lung cancer patients Jan 1, 2017 - Oct 31, 2022
Lung cancer is the most common cancer worldwide. NSCLC alone make up about 75% of all lung cancers and most hospitals currently test all NSCLC patients for EGFR mutations (pharmacogenomics) for treatment decision (personalised medicine) – i.e., patie... Read More about Blood test for clinical therapy guidance of non-small cell lung cancer patients.

Lab on a Chip NC3Rs Engagement Award Aug 15, 2016 - Aug 14, 2017
This project will deliver a programme of public engagement with innovative hands-on activities in the area of tissue/organ-on-a-chip which are emerging as life-like models to reduce and replace animal testing to school children and the general public... Read More about Lab on a Chip NC3Rs Engagement Award.