Dr Christopher Cawthorne C.Cawthorne@hull.ac.uk
Dr Christopher Cawthorne C.Cawthorne@hull.ac.uk
Dr Vicky Green V.L.Green@hull.ac.uk
Professor John Greenman J.Greenman@hull.ac.uk
Professor of Tumour Immunology
The project aims to both reduce the total number of animals used for preclinical radiotherapy experiments whilst concurrently increasing the accuracy of such investigations in order to maximise their clinical impact. This will be achieved through the development of a multipurpose small animal phantom and standardized dosimetry procedures aiming to reduce dose uncertainties in preclinical investigations (due to the steep dose responses, a 5% improvement in dose uncertainty would roughly halve the number of animal required to achieve the same statistical relevance). Inclusion of a bespoke microfluidic device, for human tissue culture, will also offer an alternative in vivo-like option for radiation-drug synergistic studies, standardizing radiobiological experiments to be undertaken by new groups using human tissue biopsies. The proposed phantom will scale down established medical physics methodologies to provide confidence and accuracy for pre-clinical studies to match current clinical practice. The project addresses pre-clinical issues identified by translational research groups, the funding bodies and the clinical community opening up new business opportunities for dosimetry services.
Type of Project | Project |
---|---|
Status | Project Complete |
Funder(s) | Innovate UK |
Value | £193,197.00 |
Project Dates | Apr 1, 2016 - Mar 31, 2019 |
Blood test for clinical therapy guidance of non-small cell lung cancer patients Jan 1, 2017 - Dec 31, 2021
TRANSFORM: Reducing Inequalities in Cancer Outcomes in Yorkshire: Realising our potential for innovation in Diagnosis, Patient Management, Survivorship and Palliative Care Research Sep 1, 2017 - Aug 31, 2022
The death rate is higher in Yorkshire than the rest of England resulting in about 200 extra deaths each year of which more than half are in Hull. There are other significant cancer outcome inequalities between different groups; for example poorer pe...
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Positron Emission Tomography research Mar 1, 2016 - Feb 28, 2017
Development of an immune-responsive 3D skin model May 1, 2019 - Jul 31, 2019
About Repository@Hull
Administrator e-mail: repository@hull.ac.uk
This application uses the following open-source libraries:
Apache License Version 2.0 (http://www.apache.org/licenses/)
Apache License Version 2.0 (http://www.apache.org/licenses/)
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
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