UKRI Covid 19 Extension Pot - Global analysis of molecular changes in head and neck squamous cell carcinoma (HNSCC) tissue maintained and treated on microfluidic devices

Overview

People Involved

Professor John Greenman J.Greenman@hull.ac.uk
Professor of Tumour Immunology

Project Description

The technician employed (0.5 FTE) on the grant started work at the Daisy Laboratories, Castle Hill Hospital, on 2nd March 2020 and was trained on all of the techniques necessary. However, due to the onset of Covid-19 only one tumour sample was obtained prior to the first lockdown at the end of March. The technician was furloughed for 6months and returned to the lab on 1st October 2020. Sample collection has been slow to get restarted due to the reduced availability of samples as the Hospital has had to prioritise dealing with Covid patients, especially during Lockdown 2. As a result of furlough the technician’s employment was extended to 30.06.20.

Status	Project Complete
Value	£13,771.00
Project Dates	Jul 1, 2020 - Sep 30, 2021
Partner Organisations	No Partners

Related Projects

Global analysis of molecular changes in head and neck squamous cell carcinoma (HNSCC) tissue maintained and treated on microfluidic devices Feb 1, 2020 - Sep 30, 2021
We have developed a microfluidic platform in which small pieces of human tissue from tumours are maintained in an in vivo-like state. These laboratory-maintained samples appear to respond to treatment in the same way as patients do clinically, but th... Read More about Global analysis of molecular changes in head and neck squamous cell carcinoma (HNSCC) tissue maintained and treated on microfluidic devices.

COVID 19 Grant Extension Allocation University of Hull Jul 1, 2020 - Sep 30, 2021

Blood test for clinical therapy guidance of non-small cell lung cancer patients Jan 1, 2017 - Oct 31, 2022
Lung cancer is the most common cancer worldwide. NSCLC alone make up about 75% of all lung cancers and most hospitals currently test all NSCLC patients for EGFR mutations (pharmacogenomics) for treatment decision (personalised medicine) – i.e., patie... Read More about Blood test for clinical therapy guidance of non-small cell lung cancer patients.

The effect of corticosteroids on the release of immune modulating factors from Graves’ disease tissue maintained using microfluidic culture. Jun 1, 2017 - May 31, 2018
Graves’ disease (GD) affects approximately 2% of adult women. Current treatments for GD include anti-thyroid drugs, radioiodine therapy and surgery, of which none tackle the underlying pathogenic process. Immunosuppressive agents are therefore of gro... Read More about The effect of corticosteroids on the release of immune modulating factors from Graves’ disease tissue maintained using microfluidic culture..

Development of a multipurpose small animal phantom for pre-clinical radiotherapy studies Apr 1, 2016 - Mar 31, 2019
The project aims to both reduce the total number of animals used for preclinical radiotherapy experiments whilst concurrently increasing the accuracy of such investigations in order to maximise their clinical impact. This will be achieved through the... Read More about Development of a multipurpose small animal phantom for pre-clinical radiotherapy studies.

The Hull-Norwich Gut-Brian Study May 31, 2016 - Jun 30, 2018
Objective To obtain mechanistic insights into how resident commensal gut bacteria (the microbiota) influences host physiology and in particular brain function and host behaviour. The focus is on identifying the pathways and molecules originating from... Read More about The Hull-Norwich Gut-Brian Study.

Lab on a Chip NC3Rs Engagement Award Aug 15, 2016 - Aug 14, 2017
This project will deliver a programme of public engagement with innovative hands-on activities in the area of tissue/organ-on-a-chip which are emerging as life-like models to reduce and replace animal testing to school children and the general public... Read More about Lab on a Chip NC3Rs Engagement Award.