Professor John Greenman J.Greenman@hull.ac.uk
Professor of Tumour Immunology
Professor John Greenman J.Greenman@hull.ac.uk
Professor of Tumour Immunology
Parkinson’s disease affects 6.1 million people globally. The number of cases has more than doubled in the last 15 years and this cannot fully be attributed to an increase in life expectancy. The social and economic costs are in excess of £3 billion annually in the UK alone, with an estimated cost of £16 thousand per family affected per annum.
The causes of Parkinson’s have been attributed to both genetic and environmental effects, ultimately leading to the death of dopamine-producing cells in the base of the brain (the substantia nigra). Although environmental and behavioural risks are involved, this has not been examined effectively.
Testing hypotheses about the causes, and testing potential treatments currently requires the use of animal models and/or patient cooperation which both have implicit sensitivities, ethical consideration and restrictions and challenges. There is currently no treatment or cure for Parkinson’s. We need to understand more about this disease in order to develop effective treatments or provide effective risk prevention advice to the population.
This need could be well served if we had a high fidelity in-vitro model of the disease.
Status | Project Complete |
---|---|
Value | £1,000.00 |
Project Dates | Jan 1, 2020 - Dec 31, 2021 |
Blood test for clinical therapy guidance of non-small cell lung cancer patients Jan 1, 2017 - Oct 31, 2022
Lung cancer is the most common cancer worldwide. NSCLC alone make up about 75% of all lung cancers and most hospitals currently test all NSCLC patients for EGFR mutations (pharmacogenomics) for treatment decision (personalised medicine) – i.e., patie...
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The effect of corticosteroids on the release of immune modulating factors from Graves’ disease tissue maintained using microfluidic culture. Jun 1, 2017 - May 31, 2018
Graves’ disease (GD) affects approximately 2% of adult women. Current treatments for GD include anti-thyroid drugs, radioiodine therapy and surgery, of which none tackle the underlying pathogenic process. Immunosuppressive agents are therefore of gro...
Read More about The effect of corticosteroids on the release of immune modulating factors from Graves’ disease tissue maintained using microfluidic culture..
Development of a multipurpose small animal phantom for pre-clinical radiotherapy studies Apr 1, 2016 - Mar 31, 2019
The project aims to both reduce the total number of animals used for preclinical radiotherapy experiments whilst concurrently increasing the accuracy of such investigations in order to maximise their clinical impact. This will be achieved through the...
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The Hull-Norwich Gut-Brian Study May 31, 2016 - Jun 30, 2018
Objective To obtain mechanistic insights into how resident commensal gut bacteria (the microbiota) influences host physiology and in particular brain function and host behaviour. The focus is on identifying the pathways and molecules originating from...
Read More about The Hull-Norwich Gut-Brian Study.
Lab on a Chip NC3Rs Engagement Award Aug 15, 2016 - Aug 14, 2017
This project will deliver a programme of public engagement with innovative hands-on activities in the area of tissue/organ-on-a-chip which are emerging as life-like models to reduce and replace animal testing to school children and the general public...
Read More about Lab on a Chip NC3Rs Engagement Award.
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