Dr Simon Calaminus S.Calaminus@hull.ac.uk
Senior Lecturer
Matrix Metalloproteinase Activated Multimodal 'Theranostic' Drug Delivery Imaging Agents For Thrombosis
People Involved
Professor David Allsup D.J.Allsup@hull.ac.uk
Professor of Haematology
Dr Jean-Sebastien Bouillard J.Bouillard@hull.ac.uk
Senior Lecturer in Physics and Nanotechnology
Bn2DT3A, a Chelator for 68Ga Positron Emission Tomography: Hydroxide Coordination Increases Biological Stability of [68Ga][Ga(Bn2DT3A)(OH)]− (2022)
Journal Article
Price, T. W., Renard, I., Prior, T. J., Kubíček, V., Benoit, D. M., Archibald, S. J., Seymour, A. M., Hermann, P., & Stasiuk, G. J. (2022). Bn2DT3A, a Chelator for 68Ga Positron Emission Tomography: Hydroxide Coordination Increases Biological Stability of [68Ga][Ga(Bn2DT3A)(OH)]−. Inorganic chemistry, 61(43), 17059–17067. https://doi.org/10.1021/acs.inorgchem.2c01992The chelator Bn2DT3A was used to produce a novel 68Ga complex for positron emission tomography (PET). Unusually, this system is stabilized by a coordinated hydroxide in aqueous solutions above pH 5, which confers sufficient stability for it to be use... Read More about Bn2DT3A, a Chelator for 68Ga Positron Emission Tomography: Hydroxide Coordination Increases Biological Stability of [68Ga][Ga(Bn2DT3A)(OH)]−.
Scandium calix[n]arenes (n= 4, 6, 8): structural, cytotoxicity and ring opening polymerization studies (2021)
Journal Article
Alshamrani, A. F., Santoro, O., Prior, T. J., Alamri, M. A., Stasiuk, G. J., Elsegood, M. R. J., & Redshaw, C. (2021). Scandium calix[n]arenes (n= 4, 6, 8): structural, cytotoxicity and ring opening polymerization studies. Dalton Transactions : an international journal of inorganic chemistry, 50(24), 8302-8306. https://doi.org/10.1039/d1dt01330kInteraction of [Sc(OR)3] (R = iPr or triflate) with p-tert-butylcalix[n]arenes, where n = 4, 6, or 8, affords a number of intriguing structural motifs, which are relatively non-toxic (cytotoxicity evaluated against cell lines HCT116 and HT-29) and a... Read More about Scandium calix[n]arenes (n= 4, 6, 8): structural, cytotoxicity and ring opening polymerization studies.
A Single-Pot Template Reaction Towards a Manganese-Based T1 Contrast Agent (2021)
Journal Article
Stasiuk, G. J., Martins, A. F., Botta, M., Prior, T. J., Price, T. W., Kenning, L., Carniato, F., Hoffmann, S. H. L., & Anbu, S. (in press). A Single-Pot Template Reaction Towards a Manganese-Based T1 Contrast Agent. Angewandte Chemie, 60(19), 10736-10744. https://doi.org/10.1002/anie.202100885Manganese-based contrast agents (MnCAs) have emerged as suitable alternatives to gadolinium-based contrast agents (GdCAs). However, due to their kinetic lability and laborious synthetic procedures, only a few MnCAs have found clinical MRI application... Read More about A Single-Pot Template Reaction Towards a Manganese-Based T1 Contrast Agent.