Professor Ron Patton R.J.Patton@hull.ac.uk
Emeritus Professor of Control and Intelligent Systems Engineering
THYME: Digital Optimisation of Mammalian Process Control.
People Involved
Project Description
Efficient and reproducible production of high quality biopharmaceuticals in large quantities is of highest priority to the biopharmaceutical industry. However, bioprocessing is a complex topic and the numerous factors affecting cell growth in culture are difficult to determine and interpret reliably. This project seeks to understand the effect of the individual gasses on bioprocessing systems during cell growth. Cell culture control systems are challenging to tune. Air, oxygen and nitrogen are used to control the dissolved oxygen concentration and carbon dioxide is used to control pH. However, control loops act independently of each other and don’t understand each other’s impact on the system and carbon dioxide can be stripped from solution by the gases used to control dissolved oxygen. As a result, volumetric flows are, most likely, much higher than necessary causing harsh growing environments, high gas consumption and challenges in process transfer and scale up, all of which increase production costs and cause waste. This project will use a model system to mimic cell growth in a bioreactor vessel and chart the effects of gases on dissolved oxygen and pH, thereby providing the data needed to developing model which could be used in predictive control systems.
| Status | Project Complete |
|---|---|
| Value | £45,403.00 |
| Project Dates | Feb 1, 2020 - May 31, 2021 |
| Partner Organisations | Teesside University Perceptive Engineering Limited Centre for Process Innovation |
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