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THYME: Digital Optimisation of Mammalian Process Control.

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Professor Ron Patton R.J.Patton@hull.ac.uk
Emeritus Professor of Control and Intelligent Systems Engineering

Improved control strategies for the environment within cell culture bioreactors (2023)
Journal Article
Jones, J., Kindembe, D., Branton, H., Lawal, N., Montero, E. L., Mack, J., Shi, S., Patton, R., & Montague, G. (2023). Improved control strategies for the environment within cell culture bioreactors. Food and Bioproducts Processing, 138, 209-220. https://doi.org/10.1016/j.fbp.2023.02.004

This paper describes the development of improved control strategies for the standard environmental conditions in a fed-batch bioreactor used for monoclonal antibody cell culture. The consequences of relying on fixed parameter PID based controllers ar... Read More about Improved control strategies for the environment within cell culture bioreactors.