Dr Ahmed Aburima A.Aburima@hull.ac.uk
Lecturer in Cardiovascular Science
PD-L1 promotes platelet activation and enhances thrombus formation.
People Involved
Dr Stefano Caserta S.Caserta@hull.ac.uk
Lecturer in Immunology
Project Description
The cardiovascular system protects the body from the risk of bleeding and heart attacks through a complex network of cells, signals and organs. Platelets are small blood cells that play a key role in maintaining blood vessel integrity. Upon injury, platelets enter an active state and release molecules to be able to stop bleeding.
We identified a platelet protein, called PD-L1, as a key player for platelet activation. We know this because platelets do not function correctly when PD-L1 is missing. In this study, we will determine what aspects of platelet function that PD-L1 regulates. To do this, we will use platelets that are deficient of PD-L1. Our work will help us understand more about platelet biology. We need new drugs that can efficiently treat people with bleeding problems, and that is only possible by fully understanding the basics of platelet biology
| Status | Project Live |
|---|---|
| Value | £110,207.00 |
| Project Dates | Oct 1, 2022 - Sep 30, 2025 |
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