Dr Barbara Guinn B.Guinn@hull.ac.uk
Reader in Biomedical Sciences
Development of a cell line that represents early stage ovarian cancer
People Involved
Project Description
We want to develop an early stage model of OC and determine whether SSX2 is a driver for this disease. To do this we wish to purchase fallopian tube cells that have been immortalised. This process of acquiring fallopian tube cells, immortalising them and maintaining them in cell culture requires a lot of skill and experience which we, like many research labs, do not have. Therefore we will ask a company called Creative Bioarray to immortalise fallopian tube cells for us.
We then plan to add one more gene to the cells to see whether that changes how they behave. Once we have added this gene we will look for signs of early stage OC developing such as:-
• Increase cell division rate
• Change in cell behaviour – morphology, adhesion, invasion
• Decrease in cell death
| Status | Project Complete |
|---|---|
| Value | £14,616.00 |
| Project Dates | Jan 1, 2022 - Jun 30, 2023 |
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