EARLY DIAPAC: EARLY DIAgnosis of PAncreatic Cancer by combined proteomics and genomics testing of pancreatic cyst fluid.

Dr Leonid Nikitenko L.Nikitenko@hull.ac.uk
Lecturer in Biomedical Sciences

Professor Anthony Maraveyas A.Maraveyas@hull.ac.uk
Professor in Cancer Medicine

A study of the incorporation and release of tissue factor as cancer cell-derived microparticles. Aug 1, 2014 - Jul 31, 2017

Can prevention of the activation of PAR2 prevent the release of procoagulant microvesicles from cancer cells, reduce the risk of VTE and contain the deterioration of the vasculature? Jul 1, 2015 - Jun 30, 2020
The study aims to demonstrate the indirect effect of Apixaban on suppressing the release of pro-inflammatory, pro-coagulant tissue factor-containing microvesicles, by inhibiting factor Xa and preventing the activation of PAR2. The study also demonstr... Read More about Can prevention of the activation of PAR2 prevent the release of procoagulant microvesicles from cancer cells, reduce the risk of VTE and contain the deterioration of the vasculature?.

Differentiating the malignant potential of pancreatic cysts Oct 1, 2017 - Dec 31, 2022
The effective diagnosis of pancreatic cancer is often quite challenging, due to a lack of disease-specific symptoms, resulting in the majority of patients presenting with advanced disease, with an associated dismal prognosis. Earlier detection of pan... Read More about Differentiating the malignant potential of pancreatic cysts.

Development of fully humanised animal free models to study the role of endothelial cells in chronic diseases. Jul 2, 2018 - Aug 28, 2018
Endothelial cells play important roles within the human body. They line blood and lymphatic vessels and regulate the work of cardiovascular and lymphatic systems. The faulty function of endothelial cells often contributes to the development of life-t... Read More about Development of fully humanised animal free models to study the role of endothelial cells in chronic diseases..

Dissecting the role of neuropeptide CGRP in human lymphatic endothelial cells Jun 10, 2019 - Aug 2, 2019
Calcitonin receptor-like receptor (CLR) is a key G-protein-coupled receptor (GPCR) that mediates the signalling of three peptides - adrenomedullin (AM), calcitonin gene-related peptide (CGRP; neuropeptide) and intermedin (IMD/AM-2). Animal models rev... Read More about Dissecting the role of neuropeptide CGRP in human lymphatic endothelial cells.