All Projects (160)

B-More: A 24-month prospective, non-interventional, international, multicentre study to describe the real-world effectiveness and usage of Alprolix in patients with haemophilia B in selected European and Middle Eastern countries Sep 1, 2019 - Dec 31, 2022
A phase IV multicentre, international study investigating the real-world efficacy of Alprolix, an extended half-life factor IX concentrate, in the management of haemophilia B.

Development of an in-vitro model for Parkinson's disease Jan 1, 2020 - Dec 31, 2021
Parkinson’s disease affects 6.1 million people globally. The number of cases has more than doubled in the last 15 years and this cannot fully be attributed to an increase in life expectancy. The social and economic costs are in excess of £3 billion a... Read More about Development of an in-vitro model for Parkinson's disease.

Establishing the sperm and seminal plasma specific mechanisms of paternal programming Jan 1, 2022 - Dec 31, 2024

Development of novel acyclic chelates for gallium-68 and scandium-44 radiometals used in PET Jun 14, 2021 - Jun 13, 2024
This proposal sets out to design, synthesize and validate the next generation of chelators for radiometals that are utilised in positron emission tomography. The radiometals; gallium-68 and scandium-44 that are produced on generators the size of a be... Read More about Development of novel acyclic chelates for gallium-68 and scandium-44 radiometals used in PET.

THYME: Summer Internship Jun 15, 2020 - Sep 15, 2020
The students will carry out a computer-based project that will focus on the metabolism of the probiotic bacterium Lactobacillus reuterii and the proteins that affect attachment to surfaces and colonisation. This work will help us to better understand... Read More about THYME: Summer Internship.

Targeting ADAM10 as a novel strategy for radiotherapy enhancement in hypoxic colorectal cancer Sep 19, 2021 - Aug 18, 2024
Radiotherapy remains one of the most effective non-invasive treatments for solid cancers, including bowel cancer. However, specific aspects of the biology of tumours, particularly the presence of low oxygen regions, remain a key limitation for its su... Read More about Targeting ADAM10 as a novel strategy for radiotherapy enhancement in hypoxic colorectal cancer.

The Biomarker Driven Antifungal Stewardship in AML: The BioDriveAFS Trial Sep 1, 2021 - Feb 28, 2026
NIHR commisioned bid for Antifungal Stewardship in Haemato-oncology.

https://www.nihr.ac.uk/documents/2026-antifungal-stewardship-in-haemato-oncology/24460

Translational nanoconstructs for targeted tissue accumulation and guided surgery in cancer May 1, 2023 - Apr 30, 2026

Investigation of chromatin-bound CBX2-associated protein complexes in advanced cancer Jul 1, 2021 - Jun 30, 2024

CageTag: Caged Theranostics as a Universal Platform for Nuclear Medicine Apr 1, 2022 - Mar 31, 2025
Molecular imaging in cancer allows specific features of the disease to be characterised. In particular, receptor expression levels can be prognostic and allow targeting of systemic radiotherapies. There are roadblocks in the widespread use of molecul... Read More about CageTag: Caged Theranostics as a Universal Platform for Nuclear Medicine.

Re-Purposing Anti-Ageing Drugs to Heal Diabetic Foot Ulcers Sep 30, 2021 - Sep 29, 2024
Diabetes UK PhD Studentship application.

An in silico genomic study of biofilm formation by foodborne bacterial pathogens Aug 10, 2020 - Nov 10, 2020

Development and publication of the booklet for the pulmonary fibrosis (disease with a degree of similarity to coronavirus disease). Nov 1, 2020 - Oct 31, 2021
Chronic diseases associated with fibrosis present a challenge for healthcare; two of them are idiopathic pulmonary fibrosis (IPF) and lymphoedema. IPF is a form of lung disease in which scarring occurs (with no known cause) leading to increased breat... Read More about Development and publication of the booklet for the pulmonary fibrosis (disease with a degree of similarity to coronavirus disease)..

Evaluating the antibacterial properties of natural cleaning products by Bio-D. Oct 19, 2020 - May 26, 2023
A pilot study to test natural cleaning products (Bio-D) for antibacterial activity with the aim to establish future collaborations.

Does PRP affect oocyte and embryo development? Jan 1, 2021 - Dec 31, 2023
Ovarian exhaustion describes the condition that occurs when the ovary runs out of follicles and is thus no longer able to ovulate oocytes. This results in infertility and is associated with menstrual disturbances as oestrogen levels fall dramaticall... Read More about Does PRP affect oocyte and embryo development?.

Bacterial Modulation of Cellular Senescence in Impaired Skin Healing Apr 1, 2022 - Mar 31, 2025

Endolysin technology for selective management of MRSA biofilms on skin and wounds Sep 1, 2021 - Apr 30, 2022

Consumables for PhD project Study of Tumour Regulatory Molecules as Markers of Malignancy in Pancreatic Cystic Lesions (TEM-PAC) Feb 1, 2021 - Jul 31, 2026

Article Processing Costs Apr 1, 2021 - Mar 31, 2023
Breaththrough Cancer Reserach has agreed to pay the APC for an article we are publishing based on work that was initiated by funds from them.

Molecular pathways of pancreatic cancer carcinogenesis from pancreatic cystic neoplasms to adenocarcinoma Sep 1, 2020 - Aug 31, 2023
Pancreatic cancer is one of the main research areas of expertise of Professor Maraveyas and his team. This is an exciting opportunity to work on molecular pathways in pancreatic tissue that reflect the early changes during carcinogenesis and transla... Read More about Molecular pathways of pancreatic cancer carcinogenesis from pancreatic cystic neoplasms to adenocarcinoma.