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Microplastics in human urine: characterisation using µFTIR and sampling challenges using healthy donors and endometriosis participants. (2024)
Journal Article
Rotchell, J. M., Austin, C., Chapman, E., Atherall, C. A., Liddle, C. R., Dunstan, T. S., …Guinn, B. (2024). Microplastics in human urine: characterisation using µFTIR and sampling challenges using healthy donors and endometriosis participants. Ecotoxicology and environmental safety, 274, Article 116208. https://doi.org/10.1016/j.ecoenv.2024.116208

Microplastics (MPs) are found in all environments, within the human food chain, and have been recently detected in several human tissues. The objective herein was to undertake an analysis of MP contamination in human urine samples, from healthy indiv... Read More about Microplastics in human urine: characterisation using µFTIR and sampling challenges using healthy donors and endometriosis participants..

Parametrization of the Calcaneus and Medial Cuneiform to Aid Potential Advancements in Flatfoot Surgery (2024)
Journal Article
Cai, Y., Pascoletti, G., Zioupos, P., Budair, B., Zanetti, E. M., Ringrose, T. J., & Junaid, S. (2024). Parametrization of the Calcaneus and Medial Cuneiform to Aid Potential Advancements in Flatfoot Surgery. Life, 14(3), Article 328. https://doi.org/10.3390/life14030328

Introduction: Flatfoot is a condition commonly seen in children; however, there is general disagreement over its incidence, characterization and correction. Painful flatfoot accompanied with musculoskeletal and soft tissue problems requires surgery t... Read More about Parametrization of the Calcaneus and Medial Cuneiform to Aid Potential Advancements in Flatfoot Surgery.

Attentional bias in psoriasis: The role of processing time and emotional valence (2023)
Journal Article
Etty, S., George, D. N., van Laarhoven, A., Kleyn, C. E., Walton, S., & Holle, H. (in press). Attentional bias in psoriasis: The role of processing time and emotional valence. British Journal of Health Psychology, https://doi.org/10.1111/bjhp.12712

Purpose: The present study explored whether people with psoriasis display an attentional bias towards disease-related threat words and whether this bias occurs relatively early during the phase of stimulus disengagement, or during a later maintained... Read More about Attentional bias in psoriasis: The role of processing time and emotional valence.

A Direct Comparison, and Prioritisation, of the Immunotherapeutic Targets Expressed by Adult and Paediatric Acute Myeloid Leukaemia Cells: A Systematic Review and Meta-Analysis (2023)
Journal Article
Morris, V., Ghazi, H., Fletcher, D., & Guinn, B. A. (2023). A Direct Comparison, and Prioritisation, of the Immunotherapeutic Targets Expressed by Adult and Paediatric Acute Myeloid Leukaemia Cells: A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences, 24(11), Article 9667. https://doi.org/10.3390/ijms24119667

Acute myeloid leukaemia (AML) is characterized by impaired myeloid differentiation resulting in an accumulation of immature blasts in the bone marrow and peripheral blood. Although AML can occur at any age, the incidence peaks at age 65. The pathobio... Read More about A Direct Comparison, and Prioritisation, of the Immunotherapeutic Targets Expressed by Adult and Paediatric Acute Myeloid Leukaemia Cells: A Systematic Review and Meta-Analysis.

A Combination of the Immunotherapeutic Drug Anti-Programmed Death 1 with Lenalidomide Enhances Specific T Cell Immune Responses against Acute Myeloid Leukemia Cells (2023)
Journal Article
Guinn, B. A., Schuler, P. J., Schrezenmeier, H., Hofmann, S., Weiss, J., Bulach, C., …Greiner, J. (2023). A Combination of the Immunotherapeutic Drug Anti-Programmed Death 1 with Lenalidomide Enhances Specific T Cell Immune Responses against Acute Myeloid Leukemia Cells. International Journal of Molecular Sciences, 24(11), Article 9285. https://doi.org/10.3390/ijms24119285

Immune checkpoint inhibitors can block inhibitory molecules on the surface of T cells, switching them from an exhausted to an active state. One of these inhibitory immune checkpoints, programmed cell death protein 1 (PD-1) is expressed on T cell subp... Read More about A Combination of the Immunotherapeutic Drug Anti-Programmed Death 1 with Lenalidomide Enhances Specific T Cell Immune Responses against Acute Myeloid Leukemia Cells.

#118. Co-creation of an educational event to support an integrated field approach, student collaboration and ongoing student growth within health care education (2023)
Presentation / Conference
Jennison, L., Combe, K., Jennison, L., Pattrick, K., Holden, G., Maile, C., & Morris, T. (2023, April). #118. Co-creation of an educational event to support an integrated field approach, student collaboration and ongoing student growth within health care education. Paper presented at RCN Education Forum National Conference & Exhibition 2023. Ambitions for change: Investing in the health and social care workforce for the future, Birmingham

The NMC Code and educational guidelines recommend nursing students work co-operatively and maintain communication with all fields of practice. Education programs should be designed to deliver learning that supports students and provides exposure ac... Read More about #118. Co-creation of an educational event to support an integrated field approach, student collaboration and ongoing student growth within health care education.

The Many Challenges of Human Experimental Itch Research (2023)
Book Chapter
Holle, H., & Lloyd, D. M. (2023). The Many Challenges of Human Experimental Itch Research. In N. P. Holmes (Ed.), Somatosensory Research Methods (161-180). New York: Humana Press. https://doi.org/10.1007/978-1-0716-3068-6_8

Itch has long been a neglected sense within somatosensory research, and with good reason: acute itch, although relatively easy to trigger, is notoriously difficult to control experimentally. Its time course and behavior cannot easily be predicted and... Read More about The Many Challenges of Human Experimental Itch Research.

Relationship between stair ascent gait speed, bone density and gait characteristics of postmenopausal women (2023)
Journal Article
Dostan, A., Dobson, C. A., & Vanicek, N. (2023). Relationship between stair ascent gait speed, bone density and gait characteristics of postmenopausal women. PLoS ONE, 18(3), Article e0283333. https://doi.org/10.1371/journal.pone.0283333

Stair ascent is a biomechanically challenging task for older women. Bone health may affect gait stability during stair walking. This study investigated the gait biomechanics associated with stair ascent in a group of postmenopausal women in relation... Read More about Relationship between stair ascent gait speed, bone density and gait characteristics of postmenopausal women.

Expert Views on Medical Involvement in the Swiss Assisted Dying Practice: “We Want to Have Our Cake and Eat It Too”? (2023)
Journal Article
Nyquist, C., Cohen-Almagor, R., & Kim, S. Y. H. (2023). Expert Views on Medical Involvement in the Swiss Assisted Dying Practice: “We Want to Have Our Cake and Eat It Too”?. AJOB Empirical Bioethics, https://doi.org/10.1080/23294515.2023.2232796

Background: Most jurisdictions that allow euthanasia and assisted suicide (AS) regulate it through the medical profession. However, the extent and nature of how medicine should be involved are debated. Swiss AS practice is unusual in that it is manag... Read More about Expert Views on Medical Involvement in the Swiss Assisted Dying Practice: “We Want to Have Our Cake and Eat It Too”?.

Accuracy and utility of blood and urine biomarkers for the noninvasive diagnosis of endometriosis: a systematic literature review and meta-analysis (2022)
Journal Article
Dolińska, W., Draper, H., Othman, L., Thompson, C., Girvan, S., Cunningham, K., …Guinn, B. A. (2023). Accuracy and utility of blood and urine biomarkers for the noninvasive diagnosis of endometriosis: a systematic literature review and meta-analysis. F&S Reviews, 4(2), 116-130. https://doi.org/10.1016/j.xfnr.2022.12.001

Objective: Endometriosis is a chronic, incurable condition associated with debilitating pain and subfertility affecting over 190 million women worldwide, which has no reliable noninvasive diagnostic tool. We aimed to determine the state-of-the-art in... Read More about Accuracy and utility of blood and urine biomarkers for the noninvasive diagnosis of endometriosis: a systematic literature review and meta-analysis.

Deluge and disease: plague, the poetry of flooding, and the history of health inequalities in Andrew Marvell’s Hull (2022)
Journal Article
Mottram, S. (2023). Deluge and disease: plague, the poetry of flooding, and the history of health inequalities in Andrew Marvell’s Hull. Seventeenth Century, https://doi.org/10.1080/0268117X.2022.2142656

This article redresses a predominant focus on London among historians of health inequalities by turning to the port town of Kingston upon Hull and offering the first demographic analysis of burial records from Hull’s ‘great plague’ of 1637–38. The ar... Read More about Deluge and disease: plague, the poetry of flooding, and the history of health inequalities in Andrew Marvell’s Hull.

Creating a Classification Module to Analysis the Usage of Mobile Health Apps (2022)
Journal Article
Azuma, K., Al Jaber, T., & Gordon, N. (2022). Creating a Classification Module to Analysis the Usage of Mobile Health Apps. Acta Scientific Computer Sciences, 4(12), 34-42

With an ageing society becoming a major issue for many countries, health-related concerns are growing and mobile health applications (MHAs) are rapidly gaining users. The applications available range from those that promote exercise to maintain healt... Read More about Creating a Classification Module to Analysis the Usage of Mobile Health Apps.

No preconscious attentional bias towards itch in healthy individuals (2022)
Journal Article
Becker, J. M., Holle, H., van Ryckeghem, D. M., Van Damme, S., Crombez, G., Veldhuijzen, D. S., …van Laarhoven, A. I. (2022). No preconscious attentional bias towards itch in healthy individuals. PLoS ONE, 17(9), Article e0273581. https://doi.org/10.1371/journal.pone.0273581

Rapidly attending towards potentially harmful stimuli to prevent possible damage to the body is a critical component of adaptive behavior. Research suggests that individuals display an attentional bias, i.e., preferential allocation of attention, for... Read More about No preconscious attentional bias towards itch in healthy individuals.

Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release (2022)
Journal Article
Diego-Taboada, A., Sathyapalan, T., Courts, F., Lorch, M., Almutairi, F., Burke, B. P., …Mackenzie, G. (2022). Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release. Journal of controlled release : official journal of the Controlled Release Society, 350, 244-255. https://doi.org/10.1016/j.jconrel.2022.08.017

Sporopollenin exine capsules (SpECs) are microcapsules derived from the outer shells (exines) of plant spore and pollen grains. This work reports the first clinical study on healthy volunteers to show enhanced bioavailability of vitamin D encapsulate... Read More about Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release.

Can contagious itch be affected by positive and negative suggestions? (2022)
Journal Article
Meeuwis, S. H., Skvortsova, A., van Laarhoven, A. I. M., Holle, H., & Evers, A. W. (in press). Can contagious itch be affected by positive and negative suggestions?. Experimental Dermatology, https://doi.org/10.1111/exd.14663

Contagious itch can be evoked by observing people scratching. Verbal suggestions about to-be-received itch can influence itch intensity, as shown by placebo research, but it is unknown whether this extends to contagious itch. The current study aimed... Read More about Can contagious itch be affected by positive and negative suggestions?.

Epithelial arginase-1 is a key mediator of age-associated delayed healing in vaginal injury (2022)
Journal Article
Wilkinson, H. N., Reubinoff, B., Shveiky, D., Hardman, M. J., & Menachem-Zidon, O. B. (2022). Epithelial arginase-1 is a key mediator of age-associated delayed healing in vaginal injury. Frontiers in endocrinology, 13, Article 927224. https://doi.org/10.3389/fendo.2022.927224

Pelvic organ prolapse is a disorder that substantially affects the quality of life of millions of women worldwide. The greatest risk factors for prolapse are increased parity and older age, with the largest group requiring surgical intervention being... Read More about Epithelial arginase-1 is a key mediator of age-associated delayed healing in vaginal injury.

Identification of the Antigens Recognised by Colorectal Cancer Patients Using Sera from Patients Who Exhibit a Crohn’s-like Lymphoid Reaction (2022)
Journal Article
Boncheva, V. B., Linnebacher, M., Kdimati, S., Draper, H., Orchard, L., Mills, K. I., …Guinn, B. A. (2022). Identification of the Antigens Recognised by Colorectal Cancer Patients Using Sera from Patients Who Exhibit a Crohn’s-like Lymphoid Reaction. Biomolecules, 12(8), 1058. https://doi.org/10.3390/biom12081058

A Crohn’s-like lymphoid reaction (CLR) is observed in about 15% of colorectal cancer (CRC) patients and is associated with favourable outcomes. To identify the immune targets recognised by CRC CLR patient sera, we immunoscreened a testes cDNA library... Read More about Identification of the Antigens Recognised by Colorectal Cancer Patients Using Sera from Patients Who Exhibit a Crohn’s-like Lymphoid Reaction.

Research priorities in diabetic foot disease (2022)
Journal Article
Collings, R., Shalhoub, J., Atkin, L., Game, F., Hitchman, L., Long, J., …Russell, D. (2022). Research priorities in diabetic foot disease. Journal of Vascular Societies Great Britain and Ireland, 1(4), 124-129. https://doi.org/10.54522/jvsgbi.2022.031

Introduction: Diabetic foot disease is a life-changing event for patients and is associated with high burdens to society in terms of cost, mortality and morbidity. The Vascular Society Diabetic Foot Specialist Interest Group (VSDFSIG), in association... Read More about Research priorities in diabetic foot disease.