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Integrin αvβ6 Positron Emission Tomography Imaging in Lung Cancer Patients Treated With Pulmonary Radiation Therapy (2020)
Journal Article
Saleem, A., Helo, Y., Win, Z., Dale, R., Cook, J., Searle, G. E., & Wells, P. (2020). Integrin αvβ6 Positron Emission Tomography Imaging in Lung Cancer Patients Treated With Pulmonary Radiation Therapy. International journal of radiation oncology, biology, physics, 107(2), 370-376. https://doi.org/10.1016/j.ijrobp.2020.02.014

© 2020 Elsevier Inc. Purpose: Post radiation therapy (RT) lung fibrosis is a major barrier to improved cure rate in lung cancer. Integrin αvβ6 plays a key role in fibrogenesis by activating transforming growth factor-β. Positron emission tomography (... Read More about Integrin αvβ6 Positron Emission Tomography Imaging in Lung Cancer Patients Treated With Pulmonary Radiation Therapy.

Clinical quantification of the integrin αvβ6 by [18F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study) (2019)
Journal Article
Lukey, P. T., Coello, C., Gunn, R., Parker, C., Wilson, F. J., Saleem, A., Garman, N., Costa, M., Kendrick, S., Onega, M., Kang’ombe, A. R., Listanco, A., Davies, J., Ramada-Magalhaes, J., Moz, S., Fahy, W. A., Maher, T. M., Jenkins, G., Passchier, J., & Marshall, R. P. (2020). Clinical quantification of the integrin αvβ6 by [18F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study). European journal of nuclear medicine and molecular imaging, 47(4), 967-979. https://doi.org/10.1007/s00259-019-04586-z

© 2019, The Author(s). Purpose: The RGD-integrin, αvβ6, plays a role in the pathogenesis of pulmonary fibrosis through activation of transforming growth factor beta (TGFβ). This study sought to quantify expression of αvβ6 in the lungs of healthy huma... Read More about Clinical quantification of the integrin αvβ6 by [18F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study).

A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvβ6 integrin inhibitor (2020)
Journal Article
Maher, T. M., Simpson, J. K., Porter, J. C., Wilson, F. J., Chan, R., Eames, R., Cui, Y., Siederer, S., Parry, S., Kenny, J., Slack, R. J., Sahota, J., Paul, L., Saunders, P., Molyneaux, P. L., Lukey, P. T., Rizzo, G., Searle, G. E., Marshall, R. P., Saleem, A., …Vahdati-Bolouri, M. (2020). A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvβ6 integrin inhibitor. Respiratory Research, 21(1), Article 75. https://doi.org/10.1186/s12931-020-01339-7

© 2020 The Author(s). Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with poor prognosis and a significant unmet medical need. This study evaluated the safety, pharmacokinetics (PK) and target engagement in the... Read More about A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvβ6 integrin inhibitor.

Translocator protein as an imaging marker of macrophage and stromal activation in rheumatoid arthritis pannus (2018)
Journal Article
Narayan, N., Owen, D. R., Mandhair, H., Smyth, E., Carlucci, F., Saleem, A., Gunn, R. N., Rabiner, E. A., Wells, L., Dakin, S. G., Sabokbar, A., & Taylor, P. C. (2018). Translocator protein as an imaging marker of macrophage and stromal activation in rheumatoid arthritis pannus. Journal of nuclear medicine, 59(7), 1125-1132. https://doi.org/10.2967/jnumed.117.202200

PET radioligands targeted to translocator protein (TSPO) offer a highly sensitive and specific means of imaging joint inflammation in rheumatoid arthritis (RA). Through high expression of TSPO on activated macrophages, TSPO PET has been widely report... Read More about Translocator protein as an imaging marker of macrophage and stromal activation in rheumatoid arthritis pannus.

A Microdose PET Study of the Safety, Immunogenicity, Biodistribution, and Radiation Dosimetry of 18F-FBA20FMDV2 for Imaging the Integrin αvβ6 (2018)
Journal Article
Keat, N., Kenny, J., Chen, K., Onega, M., Garman, N., Slack, R. J., Parker, C. A., Lumbers, R. T., Hallett, W., Saleem, A., Passchier, J., & Lukey, P. T. (2018). A Microdose PET Study of the Safety, Immunogenicity, Biodistribution, and Radiation Dosimetry of 18F-FBA20FMDV2 for Imaging the Integrin αvβ6. Journal of Nuclear Medicine Technology, 46(2), 136-143. https://doi.org/10.2967/jnmt.117.203547

The αvβ6 integrin is involved in the pathogenesis of cancer and fibrosis. A radiolabeled 20-amino-acid αvβ6-binding peptide, derived from the foot and mouth virus (NAVPNLRGDLQVLAQKVART [A20FMDV2]), has been developed to image αvβ6 levels preclinicall... Read More about A Microdose PET Study of the Safety, Immunogenicity, Biodistribution, and Radiation Dosimetry of 18F-FBA20FMDV2 for Imaging the Integrin αvβ6.

Clinical translation of a click-labeled 18F-octreotate radioligand for imaging neuroendocrine tumors (2016)
Journal Article
Dubash, S. R., Nicholas Keat, Mapelli, P., Twyman, F., Carroll, L., Kozlowski, K., Al-Nahhas, A., Saleem, A., Huiban, M., Janisch, R., Frilling, A., Sharma, R., & Aboagye, E. O. (2016). Clinical translation of a click-labeled 18F-octreotate radioligand for imaging neuroendocrine tumors. Journal of nuclear medicine, 57(8), 1207-1213. https://doi.org/10.2967/jnumed.115.169532

© 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc. We conducted the first-in-human study of 18F-fluoroethyl triazole [Tyr3] octreotate (18F-FET-βAG-TOCA) in patients with neuroendocrine tumors (NETs) to evaluate biodistribution, do... Read More about Clinical translation of a click-labeled 18F-octreotate radioligand for imaging neuroendocrine tumors.

18F-FLT PET imaging of cellular proliferation in pancreatic cancer (2015)
Journal Article
Lamarca, A., Asselin, M. C., Manoharan, P., McNamara, M. G., Trigonis, I., Hubner, R., Saleem, A., & Valle, J. W. (2016). 18F-FLT PET imaging of cellular proliferation in pancreatic cancer. Critical Reviews in Oncology/Hematology, 99, 158-169. https://doi.org/10.1016/j.critrevonc.2015.12.014

Pancreatic ductal adenocarcinoma is known for its poor prognosis. Since the development of computerized tomography, magnetic resonance and endoscopic ultrasound, novel imaging techniques have struggled to get established in the management of patients... Read More about 18F-FLT PET imaging of cellular proliferation in pancreatic cancer.

Specificity of translocator protein-targeted positron emission tomography in inflammatory joint disease (2020)
Journal Article
Helo, Y., Searle, G. E., Borghese, F., Abraham, S., & Saleem, A. (2020). Specificity of translocator protein-targeted positron emission tomography in inflammatory joint disease. EJNMMI Research, 10(1), Article 147. https://doi.org/10.1186/s13550-020-00736-9

© 2020, The Author(s). Objective: Expression of the translocator protein (TSPO) on inflammatory cells has facilitated imaging of synovitis with TSPO-targeted positron emission tomography (PET). We aimed to quantitatively assess the specificity of the... Read More about Specificity of translocator protein-targeted positron emission tomography in inflammatory joint disease.

Advanced imaging for quantification of abnormalities in the salivary glands of patients with primary Sjögren's syndrome (2020)
Journal Article
Jimenez-Royo, P., Bombardieri, M., Ciurtin, C., Kostapanos, M., Tappuni, A. R., Jordan, N., Saleem, A., Fuller, T., Port, K., Pontarini, E., Lucchesi, D., Janiczek, R., Galette, P., Searle, G., Patel, N., Kershaw, L., Gray, C., Ratia, N., van Maurik, A., de Groot, M., …Tarzi, R. (2021). Advanced imaging for quantification of abnormalities in the salivary glands of patients with primary Sjögren's syndrome. Rheumatology, 60(5), 2396-2408. https://doi.org/10.1093/rheumatology/keaa624

OBJECTIVES: To assess non-invasive imaging for detection and quantification of gland structure, inflammation and function in patients with primary Sjogren's syndrome (pSS) using PET-CT with 11C-Methionine (11C-MET; radiolabelled amino acid), and 18F-... Read More about Advanced imaging for quantification of abnormalities in the salivary glands of patients with primary Sjögren's syndrome.

Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles (2021)
Journal Article
Baghdadi, N. E., Burke, B. P., Alresheedi, T., Nigam, S., Saeed, A., Almutairi, F., Domarkas, J., Khan, A., & Archibald, S. J. (2021). Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles. Dalton Transactions : an international journal of inorganic chemistry, 50(5), 1599-1603. https://doi.org/10.1039/d0dt02626c

The CXCR4 chemokine receptor is an important biomolecular target in cancer diagnostics and therapeutics. In a new multivalent approach, iron oxide nanoparticles were conjugated with multiple binding units of a low affinity azamacrocylic CXCR4 antagon... Read More about Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles.

The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules (2021)
Journal Article
Archibald, S. J., & Allott, L. (2021). The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules. EJNMMI Radiopharmacy and Chemistry, 6(1), Article 30. https://doi.org/10.1186/s41181-021-00141-0

The aluminium-[18F]fluoride ([18F]AlF) radiolabelling method combines the favourable decay characteristics of fluorine-18 with the convenience and familiarity of metal-based radiochemistry and has been used to parallel gallium-68 radiopharmaceutical... Read More about The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules.

A practical guide to automating fluorine-18 PET radiochemistry using commercially available cassette-based platforms (2022)
Journal Article
Barnes, C., Nair, M., Aboagye, E. O., Archibald, S. J., & Allott, L. (2022). A practical guide to automating fluorine-18 PET radiochemistry using commercially available cassette-based platforms. Reaction Chemistry and Engineering, https://doi.org/10.1039/d2re00219a

The automation of positron emission tomography (PET) radiochemistry using cassette-based automated radiosynthesis platforms is an essential component of clinical translation for the vast majority of 18F-based radiopharmaceuticals. The technology is w... Read More about A practical guide to automating fluorine-18 PET radiochemistry using commercially available cassette-based platforms.

Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release (2022)
Journal Article
Diego-Taboada, A., Sathyapalan, T., Courts, F., Lorch, M., Almutairi, F., Burke, B. P., …Mackenzie, G. (2022). Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release. Journal of controlled release : official journal of the Controlled Release Society, 350, 244-255. https://doi.org/10.1016/j.jconrel.2022.08.017

Sporopollenin exine capsules (SpECs) are microcapsules derived from the outer shells (exines) of plant spore and pollen grains. This work reports the first clinical study on healthy volunteers to show enhanced bioavailability of vitamin D encapsulate... Read More about Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release.

Isothiocyanato-calix[4]phyrin-(1,1,1,1): a useful intermediate for the synthesis of derivatised anion sensors (2007)
Journal Article
Lorch, M., Boyle, R., Archibald, S., & Lewis, R. (2007). Isothiocyanato-calix[4]phyrin-(1,1,1,1): a useful intermediate for the synthesis of derivatised anion sensors. Organic & biomolecular chemistry, 5(12), 1970 - 1974. https://doi.org/10.1039/b703646a

A calix[4] phyrin-(1,1,1,1) substituted with a 4-isothiocyanatophenyl group has been synthesised and used to attach the macrocycle to a solid support. The NCS group can also be used to further functionalise the calix[4] phyrin-(1,1,1,1) by reaction w... Read More about Isothiocyanato-calix[4]phyrin-(1,1,1,1): a useful intermediate for the synthesis of derivatised anion sensors.

Ultrastable complexes for in vivo use: a bifunctional chelator incorporating a cross-bridged macrocycle (2004)
Journal Article
Boyle, R., & Archibald, S. (2004). Ultrastable complexes for in vivo use: a bifunctional chelator incorporating a cross-bridged macrocycle. Chemical communications : Chem comm / the Royal Society of Chemistry, 2212 - 2213. https://doi.org/10.1039/b406906d

The synthesis, copper(II) complexation and biotin conjugation of a bifunctional chelator incorporating a cross-bridged macrocycle are described.

A cellular assay using metal-modified fluorescence lifetime analysis for high-content screening of protein internalization (2010)
Journal Article
Archibald, S. (2010). A cellular assay using metal-modified fluorescence lifetime analysis for high-content screening of protein internalization. https://doi.org/10.1117/12.852547

Current high-content screening (HCS) techniques involve the analysis of cellular assays using high-resolution imaging combined with sophisticated algorithms for automated image analysis. Commercially available platforms are invariably highly speciali... Read More about A cellular assay using metal-modified fluorescence lifetime analysis for high-content screening of protein internalization.

Synthesis and structural characterisation of novel bimetallic dipyrromethene complexes: Rotational locking of the 5-aryl group (2004)
Journal Article
Sutton, J. M., Rogerson, E., Wilson, C. J., Sparke, A. E., Archibald, S. J., & Boyle, R. W. (2004). Synthesis and structural characterisation of novel bimetallic dipyrromethene complexes: Rotational locking of the 5-aryl group. Chemical communications : Chem comm / the Royal Society of Chemistry, 10(11), 1328-1329

Complexation of 2,8-diethyl-1,3,7,9-tetramethyl-5-(2-pyridyl)- dipyrromethene with zinc(II) generated an unprecedented structural motif for a dipyrromethene ligand, of formula Zn 2 (dipyrromethene) 2 X 2 , where X represents a coordinated anion.