Outputs (21)

Notch signalling is a potential resistance mechanism of progenitor cells within patient‐derived prostate cultures following ROS‐inducing treatments (2019)
Journal Article
Packer, J. R., Hirst, A. M., Droop, A. P., Adamson, R., Simms, M. S., Mann, V. M., Frame, F. M., O'Connell, D., & Maitland, N. J. (2019). Notch signalling is a potential resistance mechanism of progenitor cells within patient‐derived prostate cultures following ROS‐inducing treatments. FEBS Letters, https://doi.org/10.1002/1873-3468.13589

Low Temperature Plasma (LTP) generates reactive oxygen and nitrogen species, causing cell death, similarly to radiation. Radiation resistance results in tumour recurrence, however mechanisms of LTP resistance are unknown. LTP was applied to patient‐d... Read More about Notch signalling is a potential resistance mechanism of progenitor cells within patient‐derived prostate cultures following ROS‐inducing treatments.

Epigenetic Control of Gene Expression in the Normal and Malignant Human Prostate: A Rapid Response Which Promotes Therapeutic Resistance (2019)
Journal Article
Frame, F. M., & Maitland, N. J. (2019). Epigenetic Control of Gene Expression in the Normal and Malignant Human Prostate: A Rapid Response Which Promotes Therapeutic Resistance. International Journal of Molecular Sciences, 20(10), Article 2437. https://doi.org/10.3390/ijms20102437

A successful prostate cancer must be capable of changing its phenotype in response to a variety of microenvironmental influences, such as adaptation to treatment or successful proliferation at a particular metastatic site. New cell phenotypes emerge... Read More about Epigenetic Control of Gene Expression in the Normal and Malignant Human Prostate: A Rapid Response Which Promotes Therapeutic Resistance.

Effects on prostate cancer cells of targeting RNA polymerase III (2019)
Journal Article
Petrie, J. L., Swan, C., Ingram, R. M., Frame, F. M., Collins, A. T., Dumay-Odelot, H., Teichmann, M., Maitland, N. J., & White, R. J. (2019). Effects on prostate cancer cells of targeting RNA polymerase III. Nucleic Acids Research, 47(8), 3937-3956. https://doi.org/10.1093/nar/gkz128

RNA polymerase (pol) III occurs in two forms, containing either the POLR3G subunit or the related paralogue POLR3GL. Whereas POLR3GL is ubiquitous, POLR3G is enriched in undifferentiated cells. Depletion of POLR3G selectively triggers proliferative a... Read More about Effects on prostate cancer cells of targeting RNA polymerase III.

Phenotype-independent DNA methylation changes in prostate cancer (2018)
Journal Article
Pellacani, D., Droop, A. P., Frame, F. M., Simms, M. S., Mann, V. M., Collins, A. T., Eaves, C. J., & Maitland, N. J. (2018). Phenotype-independent DNA methylation changes in prostate cancer. The British Journal of Cancer, 119(9), 1133-1143. https://doi.org/10.1038/s41416-018-0236-1

Background
Human prostate cancers display numerous DNA methylation changes compared to normal tissue samples. However, definitive identification of features related to the cells’ malignant status has been compromised by the predominance of cells wit... Read More about Phenotype-independent DNA methylation changes in prostate cancer.

Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer (2017)
Journal Article
Butler, D. E., Marlein, C., Walker, H. F., Frame, F. M., Mann, V. M., Simms, M. S., Davies, B. R., Collins, A. T., & Maitland, N. J. (2017). Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer. Oncotarget, 8(34), 56698-56713. https://doi.org/10.18632/oncotarget.18082

The PI3K/AKT/mTOR pathway is frequently activated in advanced prostate cancer, due to loss of the tumour suppressor PTEN, and is an important axis for drug development. We have assessed the molecular and functional consequences of pathway blockade by... Read More about Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer.

Harvesting human prostate tissue material and culturing primary prostate epithelial cells (2016)
Book Chapter
Frame, F. M., Pellacani, D., Collins, A. T., & Maitland, N. J. (2016). Harvesting human prostate tissue material and culturing primary prostate epithelial cells. In I. J. McEwan (Ed.), The nuclear receptor superfamily: methods and protocols (181-201). Humana Press. https://doi.org/10.1007/978-1-4939-3724-0_12

In order to fully explore the biology of a complex solid tumor such as prostate cancer, it is desirable to work with patient tissue. Only by working with cells from a tissue can we take into account patient variability and tumor heterogeneity. Cell l... Read More about Harvesting human prostate tissue material and culturing primary prostate epithelial cells.

Stem cells and the role of ETS transcription factors in the differentiation hierarchy of normal and malignant prostate epithelium (2016)
Journal Article
Archer, L. K., Frame, F. M., & Maitland, N. J. (2017). Stem cells and the role of ETS transcription factors in the differentiation hierarchy of normal and malignant prostate epithelium. Journal of Steroid Biochemistry and Molecular Biology, 166, 68-83. https://doi.org/10.1016/j.jsbmb.2016.05.006

Prostate cancer is the most common cancer of men in the UK and accounts for a quarter of all new cases. Although treatment of localised cancer can be successful, there is no cure for patients presenting with invasive prostate cancer and there are les... Read More about Stem cells and the role of ETS transcription factors in the differentiation hierarchy of normal and malignant prostate epithelium.

An epigenetic reprogramming strategy to resensitize radioresistant prostate cancer cells (2016)
Journal Article
Peitzsch, C., Cojoc, M., Hein, L., Kurth, I., Mäbert, K., Trautmann, F., Klink, B., Schröck, E., Wirth, M. P., Krause, M., Stakhovsky, E. A., Telegeev, G. D., Novotny, V., Toma, M., Muders, M., Baretton, G. B., Frame, F. M., Maitland, N. J., Baumann, M., & Dubrovska, A. (2016). An epigenetic reprogramming strategy to resensitize radioresistant prostate cancer cells. Cancer Research, 76(9), 2637-2651. https://doi.org/10.1158/0008-5472.can-15-2116

Radiotherapy is a mainstay of curative prostate cancer treatment, but risks of recurrence after treatment remain significant in locally advanced disease. Given that tumor relapse can be attributed to a population of cancer stem cells (CSC) that survi... Read More about An epigenetic reprogramming strategy to resensitize radioresistant prostate cancer cells.

Low temperature plasmas as emerging cancer therapeutics: the state of play and thoughts for the future (2016)
Journal Article
Hirst, A. M., Frame, F. M., Arya, M., Maitland, N. J., & O’Connell, D. (2016). Low temperature plasmas as emerging cancer therapeutics: the state of play and thoughts for the future. Tumor Biology, 37(6), 7021-7031. https://doi.org/10.1007/s13277-016-4911-7

The field of plasma medicine has seen substantial advances over the last decade, with applications developed for bacterial sterilisation, wound healing and cancer treatment. Low temperature plasmas (LTPs) are particularly suited for medical purposes... Read More about Low temperature plasmas as emerging cancer therapeutics: the state of play and thoughts for the future.

Mechanisms of growth inhibition of primary prostate epithelial cells following gamma irradiation or photodynamic therapy including senscence, necrosis, and autophagy, but not apoptosis (2015)
Journal Article
Frame, F. M., Savoie, H., Bryden, F., Giuntini, F., Mann, V. M., Simms, M. S., Boyle, R. W., & Maitland, N. J. (2016). Mechanisms of growth inhibition of primary prostate epithelial cells following gamma irradiation or photodynamic therapy including senscence, necrosis, and autophagy, but not apoptosis. Cancer medicine, 5(1), 61-73. https://doi.org/10.1002/cam4.553

In comparison to more differentiated cells, prostate cancer stem-like cells are radioresistant, which could explain radio-recurrent prostate cancer. Improvement of radiotherapeutic efficacy may therefore require combination therapy. We have investiga... Read More about Mechanisms of growth inhibition of primary prostate epithelial cells following gamma irradiation or photodynamic therapy including senscence, necrosis, and autophagy, but not apoptosis.