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IL-10-Conditioned Dendritic Cells, Decommissioned for Recruitment of Adaptive Immunity, Elicit Innate Inflammatory Gene Products in Response to Danger Signals (2004)
Journal Article
Nolan, K. F., Croxton, R., Strong, V., Soler, D., Fairchild, P. J., Cobbold, S. P., Gonzalo, J.-A., Rubio, A., Wells, M., & Waldmann, H. (2004). IL-10-Conditioned Dendritic Cells, Decommissioned for Recruitment of Adaptive Immunity, Elicit Innate Inflammatory Gene Products in Response to Danger Signals. Journal of Immunology, 172(4), 2201-2209. https://doi.org/10.4049/jimmunol.172.4.2201

Dendritic cells (DCs) are the professional APCs of the immune system, enabling T cells to perceive and respond appropriately to potentially dangerous microbes, while also being able to maintain T cell tolerance toward self. In part, such tolerance ca... Read More about IL-10-Conditioned Dendritic Cells, Decommissioned for Recruitment of Adaptive Immunity, Elicit Innate Inflammatory Gene Products in Response to Danger Signals.

GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis (2003)
Journal Article
Sturge, J., Wienke, D., East, L., Jones, G. E., & Isacke, C. M. (2003). GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis. Journal of Cell Biology, 162(5), 789-794. https://doi.org/10.1083/jcb.200302124

Urokinase-type plasminogen activator (uPA) and its receptor (uPAR) play an important role in cell guidance and chemotaxis during normal and pathological events. uPAR is GPI-anchored and the mechanism by which it transmits intracellular polarity cues... Read More about GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis.

Transcriptional regulation of the CRLR gene in human microvascular endothelial cells by hypoxia. (2003)
Journal Article
Nikitenko, L. L., Smith, D. M., Bicknell, R., & Rees, M. C. (2003). Transcriptional regulation of the CRLR gene in human microvascular endothelial cells by hypoxia. FASEB Journal, 17(11), 1499-1501. https://doi.org/10.1096/fj.02-0993fje

Adrenomedullin is a 52 amino acid peptide that shows a remarkable range of effects on the vasculature that include inter alia, vasodilatation, regulation of permeability, inhibition of endothelial cell apoptosis, and promotion of angiogenesis. Recent... Read More about Transcriptional regulation of the CRLR gene in human microvascular endothelial cells by hypoxia..

A targeted deletion in the endocytic receptor gene Endo 180 results in a defect in collagen uptake (2003)
Journal Article
East, L., McCarthy, A., Wienke, D., Sturge, J., Ashworth, A., & Isacke, C. M. (2003). A targeted deletion in the endocytic receptor gene Endo 180 results in a defect in collagen uptake. EMBO Reports, 4(7), 710-716. https://doi.org/10.1038/sj.embor.embor882

The four members of the mannose receptor family (the mannose receptor, the M-type phospholipase A2 receptor, DEC-205 and Endo180) share a common extracellular arrangement of an amino-terminal cysteine-rich domain followed by a fibronectin type II (FN... Read More about A targeted deletion in the endocytic receptor gene Endo 180 results in a defect in collagen uptake.

Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-Kinase p110δ (2003)
Journal Article
Sawyer, C., Sturge, J., Bennett, D. C., O'Hare, M. J., Allen, W. E., Bain, J., Jones, G. E., & Vanhaesebroeck, B. (2003). Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-Kinase p110δ. Cancer Research, 63(7), 1667-1675

Class IA phosphoinositide 3′-kinases (PI3Ks) regulate many cellular processes downstream of tyrosine kinases and Ras. Despite a clear implication of PI3K in cancer, little is known about the distribution of the different PI3K isoforms in malignant ce... Read More about Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-Kinase p110δ.

Adrenomedullin and the microvasculature (2002)
Journal Article
Nikitenko, L. L., Smith, D. M., Hague, S., Wilson, C. R., Bicknell, R., & Rees, M. C. (2002). Adrenomedullin and the microvasculature. Trends in Pharmacological Sciences, 23(3), 101-103. https://doi.org/10.1016/S0165-6147%2800%2901983-0

The peptide adrenomedullin shows a remarkable range of effects on the vasculature that include vasodilatation, regulation of vascular smooth muscle cell proliferation, inhibition of endothelial apoptosis and promotion of angiogenesis. It is becoming... Read More about Adrenomedullin and the microvasculature.

N-WASP activation by a β1-integrin-dependent mechanism supports PI3K-independent chemotaxis stimulated by urokinase-type plasminogen activator (2002)
Journal Article
Sturge, J., Hamelin, J., & Jones, G. (2002). N-WASP activation by a β1-integrin-dependent mechanism supports PI3K-independent chemotaxis stimulated by urokinase-type plasminogen activator. Journal of cell science, 115(4), 699-711

Urokinase-type plasminogen activator (uPA)-uPA receptor (uPAR) and epidermal growth factor (EGF)-EGF receptor (EGFR) expression is highly correlated with breast cancer metastasis. Phosphoinositide 3-kinase (PI3K), small Rho GTPases, such as Cdc42 and... Read More about N-WASP activation by a β1-integrin-dependent mechanism supports PI3K-independent chemotaxis stimulated by urokinase-type plasminogen activator.