Skip to main content

Research Repository

Advanced Search

Outputs (66)

Use of the enhanced frog embryo teratogenesis assay-Xenopus (FETAX) to determine chemically-induced phenotypic effects (2014)
Journal Article
Hu, L., Zhu, J., Rotchell, J. M., Wu, L., Gao, J., & Shi, H. (2015). Use of the enhanced frog embryo teratogenesis assay-Xenopus (FETAX) to determine chemically-induced phenotypic effects. Science of the Total Environment, 508, 258-265. https://doi.org/10.1016/j.scitotenv.2014.11.086

The frog embryo teratogenesis assay-Xenopus (FETAX) is an established method for the evaluation of the developmental toxicities of chemicals. To develop an enhanced FETAX that is appropriate for common environmental contaminants, we exposed Xenopus t... Read More about Use of the enhanced frog embryo teratogenesis assay-Xenopus (FETAX) to determine chemically-induced phenotypic effects.

Genetic alterations and cancer formation in a European flatfish at sites of different contamination burdens (2014)
Journal Article
Lerebours, A., Stentiford, G., Bignell, J. P., Lyons, B. P., Derocles, S. A. P., & Rotchell, J. (2014). Genetic alterations and cancer formation in a European flatfish at sites of different contamination burdens. Environmental Science and Technology, 48(17), 10448-10455. https://doi.org/10.1021/es502591p

Fish diseases are an indicator for marine ecosystem health since they provide a biological end-point of historical exposure to stressors. Liver cancer has been used to monitor the effects of exposure to anthropogenic pollution in flatfish for many ye... Read More about Genetic alterations and cancer formation in a European flatfish at sites of different contamination burdens.

Effects of antagonist of retinoid X receptor (UVI3003) on morphology and gene profile of Xenopus tropicalis embryos (2014)
Journal Article
Zhu, J., Shi, H., Zhu, P., Hu, L., Wu, L., Yang, Y., & Rotchell, J. M. (2014). Effects of antagonist of retinoid X receptor (UVI3003) on morphology and gene profile of Xenopus tropicalis embryos. Environmental Toxicology and Pharmacology, 38(1), 153-162. https://doi.org/10.1016/j.etap.2014.05.010

We exposed Xenopus tropicalis embryos to a selective antagonist of retinoid X receptor (UVI3003). UVI3003 induced multiple malformations at the concentrations of 200-1000. μg/L after 48. h exposure. The most prominent malformations affected brains, e... Read More about Effects of antagonist of retinoid X receptor (UVI3003) on morphology and gene profile of Xenopus tropicalis embryos.

Evidence of altered fertility in female roach (Rutilus rutilus) from the River Seine (France) (2014)
Journal Article
Gerbron, M., Geraudie, P., Fernandes, D., Rotchell, J. M., Porte, C., & Minier, C. (2014). Evidence of altered fertility in female roach (Rutilus rutilus) from the River Seine (France). Environmental pollution, 191, 58-62. https://doi.org/10.1016/j.envpol.2014.04.015

A large variety of anthropogenic chemicals present in the aquatic environment have been shown to be able to alter the endocrine system of exposed organisms, potentially impacting their reproductive function. The aim of this study was to assess the ef... Read More about Evidence of altered fertility in female roach (Rutilus rutilus) from the River Seine (France).

Advanced diagnostics applied to fish liver tumours: Relating pathology to underlying molecular aetiology (2013)
Journal Article
Lerebours, A., Bignell, J. P., Stentiford, G. D., Feist, S. W., Lyons, B. P., & Rotchell, J. M. (2013). Advanced diagnostics applied to fish liver tumours: Relating pathology to underlying molecular aetiology. Marine pollution bulletin, 72(1), 94-98. https://doi.org/10.1016/j.marpolbul.2013.04.016

Liver tumours in flatfish have been diagnosed using histopathology for decades in order to monitor the impacts of marine pollution in coastal and estuarine environments. This traditional method has been coupled with molecular analyses of tumours in t... Read More about Advanced diagnostics applied to fish liver tumours: Relating pathology to underlying molecular aetiology.

Intersex in scrobicularia plana: transcriptomic analysis reveals novel genes involved in endocrine disruption (2012)
Journal Article
Ciocan, C. M., Cubero-Leon, E., Peck, M. R., Langston, W. J., Pope, N., Minier, C., & Rotchell, J. M. (2012). Intersex in scrobicularia plana: transcriptomic analysis reveals novel genes involved in endocrine disruption. Environmental Science and Technology, 46(23), 12936-12942. https://doi.org/10.1021/es302948g

Intersex, the appearance of female characteristics in male gonads, has been identified in a wide range of aquatic species worldwide, yet the underpinning molecular etiology remains uncharacterised. The presence of intersex has been shown to be a wide... Read More about Intersex in scrobicularia plana: transcriptomic analysis reveals novel genes involved in endocrine disruption.

Combined effect of cadmium and estradiol on the endocrine system of roach (Rutilus rutilus): In vitro and in vivo approaches (2012)
Journal Article
Gerbron, M., Geraudie, P., Xuereb, B., Hill, E. M., Rotchell, J., & Minier, C. (2012). Combined effect of cadmium and estradiol on the endocrine system of roach (Rutilus rutilus): In vitro and in vivo approaches. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 163(Supplement), S34-S34. https://doi.org/10.1016/j.cbpa.2012.05.099

Two CYP3A-like genes in the marine mussel Mytilus edulis: mRNA expression modulation following short-term exposure to endocrine disruptors (2012)
Journal Article
Cubero-Leon, E., Puinean, A. M., Labadie, P., Ciocan, C., Itoh, N., Kishida, M., Osada, M., Minier, C., Hill, E. M., & Rotchell, J. M. (2012). Two CYP3A-like genes in the marine mussel Mytilus edulis: mRNA expression modulation following short-term exposure to endocrine disruptors. Marine environmental research, 74, 32-39. https://doi.org/10.1016/j.marenvres.2011.11.012

Members of the vertebrate CYP3A subfamily are involved in the metabolism of steroids and a wide range of xenobiotics. In this study two CYP3A- like mRNAs have been isolated from the mussel (Mytilus edulis), and their seasonal expression profile and m... Read More about Two CYP3A-like genes in the marine mussel Mytilus edulis: mRNA expression modulation following short-term exposure to endocrine disruptors.

Metabolomic analysis of sex specific metabolites in gonads of the mussel, Mytilus edulis (2012)
Journal Article
Cubero-Leon, E., Minier, C., Hill, E. M., & Rotchell, J. (2012). Metabolomic analysis of sex specific metabolites in gonads of the mussel, Mytilus edulis. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 7(2), 212-219. https://doi.org/10.1016/j.cbd.2012.03.002

Marine mussels have been used as sentinel organisms to monitor exposure to a variety of chemical contaminants, including endocrine disrupting chemicals, in the aquatic environment. Although they are an important species for use in ecotoxicology inves... Read More about Metabolomic analysis of sex specific metabolites in gonads of the mussel, Mytilus edulis.