Outputs (54)

Feasibility of a novel exercise prehabilitation programme in patients scheduled for elective colorectal surgery: a feasibility randomised controlled trial (2019)
Journal Article
Northgraves, M. J., Arunachalam, L., Madden, L. A., Marshall, P., Hartley, J. E., MacFie, J., & Vince, R. V. (2019). Feasibility of a novel exercise prehabilitation programme in patients scheduled for elective colorectal surgery: a feasibility randomised controlled trial. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, https://doi.org/10.1007/s00520-019-05098-0

© 2019, The Author(s). Background and objectives: To investigate the feasibility of delivering a functional exercise-based prehabilitation intervention and its effects on postoperative length of hospital stay, preoperative physical functioning and he... Read More about Feasibility of a novel exercise prehabilitation programme in patients scheduled for elective colorectal surgery: a feasibility randomised controlled trial.

A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol (2019)
Journal Article
Wright, C., Hart, S. P., Allgar, V., English, A., Swan, F., Dyson, J., Richardson, G., Twiddy, M., Cohen, J., Hussain, J., Johnson, M., Hargreaves, I., & Crooks, M. G. (2019). A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol. ERJ Open Research, 5(4), Article 0186. https://doi.org/10.1183/23120541.00186-2019

Introduction: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease that causes breathlessness and cough that worsen over time, limiting daily activities and negatively impacting quality of life. Although treatments are now av... Read More about A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol.

Effectiveness of surgical fixation for lateral compression type one (LC-1) fragility fractures of the pelvis: a systematic review (2019)
Journal Article
Booth, A., Ingoe, H. M. A., Northgraves, M., Coleman, E., Harden, M., Kassam, J., Kwok, I., Hilton, C., Bates, P., & McDaid, C. (2019). Effectiveness of surgical fixation for lateral compression type one (LC-1) fragility fractures of the pelvis: a systematic review. BMJ open, 9(5), Article e024737. https://doi.org/10.1136/bmjopen-2018-024737

© 2019 Author(s). Objectives: To undertake a systematic review of the evidence base for the effectiveness of surgical fixation of lateral compression (LC-1) fragility fractures of the pelvis compared with non-surgical approaches. Searches: MEDLINE, E... Read More about Effectiveness of surgical fixation for lateral compression type one (LC-1) fragility fractures of the pelvis: a systematic review.

Knee Replacement Bandaging Study (KReBS) evaluating the effect of a two-layer compression bandage system on knee function following total knee arthroplasty: study protocol for a randomised controlled trial. (2019)
Journal Article
Cook, L., Northgraves, M. J., Fairhurst, C., Ronaldson, S., Torgerson, D. J., Kent, J., & Reed, M. (2019). Knee Replacement Bandaging Study (KReBS) evaluating the effect of a two-layer compression bandage system on knee function following total knee arthroplasty: study protocol for a randomised controlled trial. Trials, 20(1), Article 261. https://doi.org/10.1186/s13063-019-3344-1

Background: Data from a feasibility study suggest that the use of an inelastic, short-stretch compression bandage following total knee arthroplasty is a safe technique that may improve patient-reported health outcomes, and that it is feasible to recr... Read More about Knee Replacement Bandaging Study (KReBS) evaluating the effect of a two-layer compression bandage system on knee function following total knee arthroplasty: study protocol for a randomised controlled trial..

Study reporting guidelines : how valid are they? (2019)
Journal Article
Arundel, C., James, S., Northgraves, M., & Booth, A. (2019). Study reporting guidelines : how valid are they?. Contemporary clinical trials communications, 14, Article 100343. https://doi.org/10.1016/j.conctc.2019.100343

Reporting guidelines help improve the reporting of specific study designs, and clear guidance on the best approaches for developing guidelines is available. The methodological strength, or validation of guidelines is however unclear. This article exp... Read More about Study reporting guidelines : how valid are they?.

Statistical design and analysis in trials of proportionate interventions: a systematic review (2019)
Journal Article
Candlish, J., Teare, M. D., Cohen, J., & Bywater, T. (2019). Statistical design and analysis in trials of proportionate interventions: a systematic review. Trials, 20(1), Article 151. https://doi.org/10.1186/s13063-019-3206-x

Background: In proportionate or adaptive interventions, the dose or intensity can be adjusted based on individual need at predefined decision stages during the delivery of the intervention. The development of such interventions may require an evaluat... Read More about Statistical design and analysis in trials of proportionate interventions: a systematic review.

Tissue inflammation signatures point towards resolution in adhesive capsulitis (2019)
Journal Article
Dakin, S. G., Rangan, A., Martinez, F., Brealey, S., Northgraves, M., Kottam, L., Cooper, C., Buckley, C. D., & Carr, A. J. (2019). Tissue inflammation signatures point towards resolution in adhesive capsulitis. Rheumatology, 58(6), 1109–1111. https://doi.org/10.1093/rheumatology/kez007

Proresolving receptors, macrophage and fibroblast activation point towards a resolving inflammatory milieu in adhesive capsulitis.

Oral anticoagulation is preferable to injected, but only if it is safe and effective: An interview study of patient and carer experience of oral and injected anticoagulant therapy for cancer-associated thrombosis in the select-d trial (2018)
Journal Article
Hutchinson, A., Rees, S., Young, A., Maraveyas, A., Date, K., & Johnson, M. J. (2019). Oral anticoagulation is preferable to injected, but only if it is safe and effective: An interview study of patient and carer experience of oral and injected anticoagulant therapy for cancer-associated thrombosis in the select-d trial. Palliative medicine, 33(5), 510-517. https://doi.org/10.1177/0269216318815377

Background: Cancer patients have a four- to fivefold greater risk of thrombosis than the general population. Recommended treatment for cancer-associated thrombosis is 3–6 months of low-molecular-weight heparin. The ‘select-d’ trial is an open-label,... Read More about Oral anticoagulation is preferable to injected, but only if it is safe and effective: An interview study of patient and carer experience of oral and injected anticoagulant therapy for cancer-associated thrombosis in the select-d trial.

Selecting pregnant or postpartum women with suspected pulmonary embolism for diagnostic imaging: The DiPEP diagnostic study with decision-analysis modelling (2018)
Journal Article
Goodacre, S., Horspool, K., Shephard, N., Pollard, D., Hunt, B. J., Fuller, G., Nelson-Piercy, C., Knight, M., Thomas, S., Lecky, F., & Cohen, J. (2018). Selecting pregnant or postpartum women with suspected pulmonary embolism for diagnostic imaging: The DiPEP diagnostic study with decision-analysis modelling. Health Technology Assessment, 22(47), V-229. https://doi.org/10.3310/hta22470

Background
Pulmonary embolism (PE) is a leading cause of death in pregnancy and post partum, but the symptoms of PE are common in normal pregnancy. Simple diagnostic tests are needed to select women for diagnostic imaging.

Objective
To estimate the... Read More about Selecting pregnant or postpartum women with suspected pulmonary embolism for diagnostic imaging: The DiPEP diagnostic study with decision-analysis modelling.

Does early intervention improve outcomes in the physiotherapy management of lumbar radicular syndrome? Results of the POLAR pilot randomised controlled trial (2018)
Journal Article
Reddington, M., Walters, S. J., Cohen, J., Baxter, S. K., & Cole, A. (2018). Does early intervention improve outcomes in the physiotherapy management of lumbar radicular syndrome? Results of the POLAR pilot randomised controlled trial. BMJ open, 8(7), Article e021631. https://doi.org/10.1136/bmjopen-2018-021631

© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY. Published by BMJ. Objective To investigate the feasibility of undertaking a definitive randomised controlled trial (RCT). Setting This was a pilot, pragmatic superiority RCT with... Read More about Does early intervention improve outcomes in the physiotherapy management of lumbar radicular syndrome? Results of the POLAR pilot randomised controlled trial.