Urine biomarkers for the early detection of ovarian cancer – are we there yet?

Grayson, Kelly; Gregory, Ebony; Khan, Ghazala; Guinn, Barbara-Ann

Abstract

Ovarian cancer affects around 7500 women in the United Kingdom every year. Despite this, there is no effective screening strategy or standard treatment for ovarian cancer. If diagnosed during stage I, ovarian cancer has a 90% 5-year survival rate; however, there is usually a masking of symptoms which leads to an often late-stage diagnosis and correspondingly poor survival rate. Current diagnostic methods are invasive and consist of a pelvic examination, transvaginal ultrasonography, and blood tests to detect cancer antigen 125 (CA125). Unfortunately, surgery is often still required to make a positive diagnosis. To address the need for accurate, specific, and non-invasive diagnostic methods, there has been an increased interest in biomarkers identified through non-invasive tests as tools for the earlier diagnosis of ovarian cancer. Although most studies have focused on the identification of biomarkers in blood, the ease of availability of urine and the high patient compliance rates suggest that it could provide a promising resource for the screening of patients for ovarian cancer.

Citation

Grayson, K., Gregory, E., Khan, G., & Guinn, B.-A. (2019). Urine biomarkers for the early detection of ovarian cancer – are we there yet?. Biomarkers in Cancer, 11, Article 1983097. https://doi.org/10.1177/1179299x19830977

• Journal Article Type: Article
• Acceptance Date: Jan 24, 2019
• Online Publication Date: Feb 26, 2019
• Publication Date: 2019-01
• Deposit Date: Mar 13, 2019
• Publicly Available Date: Mar 13, 2019
• Journal: Biomarkers in Cancer
• Print ISSN: 1179-299X
• Publisher: Libertas Academica
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Article Number: 1983097
• DOI: https://doi.org/10.1177/1179299x19830977
• Keywords: Biomarker; Ovarian cancer; Early detection; Diagnosis; Urine
• Public URL: https://hull-repository.worktribe.com/output/1331131
• Publisher URL: https://journals.sagepub.com/doi/10.1177/1179299X19830977
• Contract Date: Mar 13, 2019