Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk

Crowther-Swanepoel, Dalemari; Broderick, Peter; Di Bernardo, Maria Chiara; Dobbins, Sara E.; Torres, María; Mansouri, Mahmoud; Ruiz-Ponte, Clara; Enjuanes, Anna; Rosenquist, Richard; Carracedo, Angel; Jurlander, Jesper; Campo, Elias; Juliusson, Gunnar; Montserrat, Emilio; Smedby, Karin E.; Dyer, Martin J.S.; Matutes, Estella; Dearden, Claire; Sunter, Nicola J.; Hall, Andrew G.; Mainou-Fowler, Tryfonia; Jackson, Graham H.; Summerfield, Geoffrey; Harris, Robert J.; Pettitt, Andrew R.; Allsup, David J.; Bailey, James R.; Pratt, Guy; Pepper, Chris; Fegan, Chris; Parker, Anton; Oscier, David; Allan, James M.; Catovsky, Daniel; Houlston, Richard S.

Abstract

To identify new risk variants for chronic lymphocytic leukemia (CLL), we conducted a genome-wide association study of 299,983 tagging SNPs, with validation in four additional series totaling 2,503 cases and 5,789 controls. We identified four new risk loci for CLL at 2q37.3 (rs757978, FARP2; odds ratio (OR) = 1.39; P = 2.11 × 10 9), 8q24.21 (rs2456449; OR = 1.26; P = 7.84 × 10 10), 15q21.3 (rs7169431; OR = 1.36; P = 4.74 × 10 7) and 16q24.1 (rs305061; OR = 1.22; P = 3.60 × 10 7). We also found evidence for risk loci at 15q25.2 (rs783540, CPEB1; OR = 1.18; P = 3.67 × 10 6) and 18q21.1 (rs1036935; OR = 1.22; P = 2.28 × 10 6). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy. © 2010 Nature America, Inc. All rights reserved.

Citation

Crowther-Swanepoel, D., Broderick, P., Di Bernardo, M. C., Dobbins, S. E., Torres, M., Mansouri, M., Ruiz-Ponte, C., Enjuanes, A., Rosenquist, R., Carracedo, A., Jurlander, J., Campo, E., Juliusson, G., Montserrat, E., Smedby, K. E., Dyer, M. J., Matutes, E., Dearden, C., Sunter, N. J., Hall, A. G., …Houlston, R. S. (2010). Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk. Nature genetics, 42(2), 132-136. https://doi.org/10.1038/ng.510

• Journal Article Type: Article
• Acceptance Date: Nov 20, 2009
• Online Publication Date: Jan 10, 2010
• Publication Date: Feb 1, 2010
• Deposit Date: Apr 4, 2022
• Publicly Available Date: Oct 9, 2024
• Journal: Nature Genetics
• Print ISSN: 1061-4036
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 42
• Issue: 2
• Pages: 132-136
• DOI: https://doi.org/10.1038/ng.510
• Public URL: https://hull-repository.worktribe.com/output/3578035