Thomas M Drake
Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study
Drake, Thomas M; Docherty, Annemarie B; Harrison, Ewen M; Quint, Jennifer K; Adamali, Huzaifa; Agnew, Sarah; Babu, Suresh; Barber, Christopher M; Barratt, Shaney; Bendstrup, Elisabeth; Bianchi, Stephen; Villegas, Diego Castillo; Chaudhuri, Nazia; Chua, Felix; Coker, Robina; Chang, William; Crawshaw, Anjali; Crowley, Louise E.; Dosanjh, Davinder; Fiddler, Christine A; Forrest, Ian A.; George, Peter M; Gibbons, Michael A; Groom, Katherine; Haney, Sarah; Hart, Simon P.; Heiden, Emily; Henry, Michael; Ho, Ling Pei; Hoyles, Rachel K; Hutchinson, John; Hurley, Killian; Jones, Mark G; Jones, Steve; Kokosi, Maria; Kreuter, Michael; Mackay, Laura S; Mahendran, Siva; Margaritopoulos, George; Molina-Molina, Maria; Molyneaux, Philip L; O'Brien, Aidan; O'Reilly, Katherine; Packham, Alice; Parfrey, Helen; Poletti, Venerino; Porter, Joanna C.; Renzoni, Elisabetta; Rivera-Ortega, Pilar; Russell, Anne Marie; Saini, Gauri; Spencer, Lisa G; Stella, Giulia M.; Stone, Helen; Sturney, Sharon; Thickett, Davi...
Authors
Annemarie B Docherty
Ewen M Harrison
Jennifer K Quint
Huzaifa Adamali
Sarah Agnew
Suresh Babu
Christopher M Barber
Shaney Barratt
Elisabeth Bendstrup
Stephen Bianchi
Diego Castillo Villegas
Nazia Chaudhuri
Felix Chua
Robina Coker
William Chang
Anjali Crawshaw
Louise E. Crowley
Davinder Dosanjh
Christine A Fiddler
Ian A. Forrest
Peter M George
Michael A Gibbons
Katherine Groom
Sarah Haney
Professor Simon Hart S.Hart@hull.ac.uk
Professor in Respiratory Medicine
Emily Heiden
Michael Henry
Ling Pei Ho
Rachel K Hoyles
John Hutchinson
Killian Hurley
Mark G Jones
Steve Jones
Maria Kokosi
Michael Kreuter
Laura S Mackay
Siva Mahendran
George Margaritopoulos
Maria Molina-Molina
Philip L Molyneaux
Aidan O'Brien
Katherine O'Reilly
Alice Packham
Helen Parfrey
Venerino Poletti
Joanna C. Porter
Elisabetta Renzoni
Pilar Rivera-Ortega
Anne Marie Russell
Gauri Saini
Lisa G Spencer
Giulia M. Stella
Helen Stone
Sharon Sturney
David Thickett
Muhunthan Thillai
Tim Wallis
Katie Ward
Athol U Wells
Alex West
Melissa Wickremasinghe
Felix Woodhead
Glenn Hearson
Lucy Howard
J. Kenneth Baillie
Peter J.M. Openshaw
Malcolm G Semple
Iain Stewart
R. Gisli Jenkins
ISARIC4C Investigators
Abstract
Rationale: The impact of coronavirus disease (COVID-19) on patients with interstitial lung disease (ILD) has not been established.Objectives: To assess outcomes in patients with ILD hospitalized for COVID-19 versus those without ILD in a contemporaneous age-, sex-, and comorbidity-matched population.Methods: An international multicenter audit of patients with a prior diagnosis of ILD admitted to the hospital with COVID-19 between March 1 and May 1, 2020, was undertaken and compared with patients without ILD, obtained from the ISARIC4C (International Severe Acute Respiratory and Emerging Infection Consortium Coronavirus Clinical Characterisation Consortium) cohort, admitted with COVID-19 over the same period. The primary outcome was survival. Secondary analysis distinguished idiopathic pulmonary fibrosis from non-idiopathic pulmonary fibrosis ILD and used lung function to determine the greatest risks of death.Measurements and Main Results: Data from 349 patients with ILD across Europe were included, of whom 161 were admitted to the hospital with laboratory or clinical evidence of COVID-19 and eligible for propensity score matching. Overall mortality was 49% (79/161) in patients with ILD with COVID-19. After matching, patients with ILD with COVID-19 had significantly poorer survival (hazard ratio [HR], 1.60; confidence interval, 1.17-2.18; P = 0.003) than age-, sex-, and comorbidity-matched controls without ILD. Patients with an FVC of
Citation
Drake, T. M., Docherty, A. B., Harrison, E. M., Quint, J. K., Adamali, H., Agnew, S., …ISARIC4C Investigators. (2020). Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study. American Journal of Respiratory and Critical Care Medicine, 202(12), 1656-1665. https://doi.org/10.1164/rccm.202007-2794OC
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 2, 2020 |
Online Publication Date | Oct 2, 2020 |
Publication Date | Dec 15, 2020 |
Deposit Date | Oct 7, 2020 |
Publicly Available Date | Oct 9, 2020 |
Journal | American journal of respiratory and critical care medicine |
Print ISSN | 1073-449X |
Electronic ISSN | 1535-4970 |
Publisher | American Thoracic Society |
Peer Reviewed | Peer Reviewed |
Volume | 202 |
Issue | 12 |
Pages | 1656-1665 |
DOI | https://doi.org/10.1164/rccm.202007-2794OC |
Keywords | COVID-19; IPF; ILD; Obesity; Lung function; Hospitalisation |
Public URL | https://hull-repository.worktribe.com/output/3632790 |
Publisher URL | https://www.atsjournals.org/doi/10.1164/rccm.202007-2794OC |
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Copyright Statement
Copyright © 2020 by the American Thoracic Society. This article is open access and distributed under the terms of the Creative
Commons Attribution Non-Commercial No Derivatives License 4.0
(http://creativecommons.org/licenses/by-nc-nd/4.0/).
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Copyright Statement
Copyright © 2020 by the American Thoracic Society. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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