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Normative reference values for estimated cardiorespiratory fitness in apparently healthy British men and women

Ingle, Lee; Rigby, Alan; Brodie, David; Sandercock, Gavin

Authors

Alan Rigby

David Brodie

Gavin Sandercock



Contributors

Hugo A. Kerhervé
Editor

Abstract

Copyright: © 2020 Ingle et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Objectives To develop normative reference standards for estimated cardiorespiratory fitness (eCRF) measured from treadmill-based incremental exercise testing in ~12 000 British men and women. Methods Cross-sectional study using retrospectively collected eCRF data from five preventative health screening clinics in the United Kingdom. Reference centiles were developed using a parametric approach by fitting fractional polynomials. We selected the ‘best’ powers by considering both the smallest deviance, and clinical knowledge from the following set of a priori decided powers (-2,-1,-0.5, 0, 0.5,1,2,3). A series of fractional polynomials (FPs) were investigated with three-parameters (median, standard deviation and skewness). The following reference centiles were plotted (3, 5, 10, 25, 50, 75, 90, 95, 97). Results We included 9 204 males (median [25th,75th centiles] age 48 [44, 53] years; BMI 27 {25, 29] kgm-2; peak VO2 36.9 [30.5, 44.7] mlkg-1min-1) and 2 687 females (age 48, [41, 51] years; BMI 24 {22, 27] kgm-2; peak VO2 36.5 [30.1, 44.8] mlkg-1min-1) in our analysis to develop the normative values. Conclusion Reference values and nomograms for eCRF were derived from a relatively large cohort of preventative health care screening examinations of apparently healthy British men and women. Age- and sex-specific eCRF percentiles were similar to data from international cohort studies. The adoption of submaximal exercise testing protocols reduces individual risk when exercise history is unknown and testing is conducted in a community-based setting. Our findings can be used by health professionals to help guide clinical decision making.

Citation

Ingle, L., Rigby, A., Brodie, D., & Sandercock, G. (2020). Normative reference values for estimated cardiorespiratory fitness in apparently healthy British men and women. PLoS ONE, 15(10), https://doi.org/10.1371/journal.pone.0240099

Journal Article Type Article
Acceptance Date Sep 19, 2020
Online Publication Date Oct 8, 2020
Publication Date Oct 8, 2020
Deposit Date Oct 9, 2020
Publicly Available Date Oct 12, 2020
Journal PLoS ONE
Print ISSN 1932-6203
Electronic ISSN 1932-6203
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 15
Issue 10
Article Number e0240099
DOI https://doi.org/10.1371/journal.pone.0240099
Keywords General Biochemistry, Genetics and Molecular Biology; General Agricultural and Biological Sciences; General Medicine
Public URL https://hull-repository.worktribe.com/output/3633514
Publisher URL https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0240099

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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/

Copyright Statement
© 2020 Ingle et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.





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