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A mixed-method feasibility study of a novel transitional regime of incremental haemodialysis: study design and protocol

Twiddy, Maureen; Hazara, Adil; Bhandari, Sunil; Allgar, Victoria

Authors

Adil Hazara

Sunil Bhandari

Victoria Allgar



Abstract

Background: Incremental haemodialysis/haemodiafiltration (HD) may help reduce early mortality rates in patients starting HD. This mixed-method feasibility study aims to test the acceptability, tolerance and safety of a novel incremental HD regime, and to study its impact on parameters of patient wellbeing. Method: We aim to enrol 20 patients who will commence HD twice-weekly with progressive increases in duration and frequency, achieving conventional treatment times over 15weeks (incremental group). Participants will be followed-up for 6months and will undergo regular tests including urine collections, bio-impedance analyses and quality-of-life questionnaires. Semi-structured interviews will be conducted to explore patients’ prior expectations from HD, their motivations for participation and experiences of receiving incremental HD. For comparison of safety and indicators of dialysis adequacy, a cohort of 40 matched patients who previously received conventional HD will be constructed from local dialysis records (historical controls). Results: Data will be recorded on the numbers screened and proportions consented and completing the study (primary outcome). Incremental and conventional groups will be compared in terms of differences in blood pressure control, interdialytic weight changes, indicators of dialysis adequacy and differences in adverse and serious adverse events. In analyses restricted to incremental group, measurements of RRF, fluid load and quality-of-life during follow-up will be compared with baseline values. From patient interviews, a narrative description of key themes along with anonymised quotes will be presented. Conclusion: Results from this study will address a significant knowledge gap in the prescription HD therapy and inform the development novel future therapy regimens.

Citation

Twiddy, M., Hazara, A., Bhandari, S., & Allgar, V. (in press). A mixed-method feasibility study of a novel transitional regime of incremental haemodialysis: study design and protocol. Clinical and Experimental Nephrology, https://doi.org/10.1007/s10157-021-02072-1

Journal Article Type Article
Acceptance Date Apr 26, 2021
Online Publication Date Jun 8, 2021
Deposit Date Apr 29, 2021
Publicly Available Date Jun 9, 2021
Journal Clinical and Experimental Nephrology
Print ISSN 1342-1751
Electronic ISSN 1437-7799
Publisher Springer
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1007/s10157-021-02072-1
Keywords Haemodialysis; Hemodialysis; Incremental HD; Chronic kidney disease; Dialysis
Public URL https://hull-repository.worktribe.com/output/3761357

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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/

Copyright Statement
© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.





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