The development of RAPTA compounds for the treatment of tumors

Murray, Benjamin S.; Babak, Maria V.; Hartinger, Christian G.; Dyson, Paul J.

Abstract

© 2015 Elsevier B.V. Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties. Herein a comprehensive review of this class of compounds is provided. A discussion of the basic RAPTA structure is given together with the ways it has been modified to elucidate the key role of each part and to afford targeted derivatives. The various mechanistic studies conducted on RAPTA compounds are described and these are linked to the observed macroscopic biological properties. Ultimately, the review shows that certain RAPTA compounds display quite unique properties that point towards a clinical investigation.

Citation

Murray, B. S., Babak, M. V., Hartinger, C. G., & Dyson, P. J. (2016). The development of RAPTA compounds for the treatment of tumors. Coordination chemistry reviews, 306(P1), 86-114. https://doi.org/10.1016/j.ccr.2015.06.014

• Acceptance Date: Jun 29, 2015
• Online Publication Date: Jul 7, 2015
• Publication Date: Jan 1, 2016
• Deposit Date: Oct 14, 2015
• Publicly Available Date: Nov 23, 2017
• Journal: Coordination chemistry reviews
• Print ISSN: 0010-8545
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 306
• Issue: P1
• Pages: 86-114
• DOI: https://doi.org/10.1016/j.ccr.2015.06.014
• Keywords: RAPTA; Bioorganometallic chemistry; Cancer; Metastasis; Angiogenesis
• Public URL: https://hull-repository.worktribe.com/output/379675
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S0010854515002192
• Additional Information: Authors' accepted manuscript of article published in: Coordination chemistry reviews, 2016, v.306, part 1