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The development of RAPTA compounds for the treatment of tumors

Murray, Benjamin S.; Babak, Maria V.; Hartinger, Christian G.; Dyson, Paul J.


Benjamin S. Murray

Maria V. Babak

Christian G. Hartinger

Paul J. Dyson


© 2015 Elsevier B.V. Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties. Herein a comprehensive review of this class of compounds is provided. A discussion of the basic RAPTA structure is given together with the ways it has been modified to elucidate the key role of each part and to afford targeted derivatives. The various mechanistic studies conducted on RAPTA compounds are described and these are linked to the observed macroscopic biological properties. Ultimately, the review shows that certain RAPTA compounds display quite unique properties that point towards a clinical investigation.


Murray, B. S., Babak, M. V., Hartinger, C. G., & Dyson, P. J. (2016). The development of RAPTA compounds for the treatment of tumors. Coordination chemistry reviews, 306(P1), 86-114.

Acceptance Date Jun 29, 2015
Online Publication Date Jul 7, 2015
Publication Date Jan 1, 2016
Deposit Date Oct 14, 2015
Publicly Available Date Nov 23, 2017
Journal Coordination chemistry reviews
Print ISSN 0010-8545
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 306
Issue P1
Pages 86-114
Keywords RAPTA; Bioorganometallic chemistry; Cancer; Metastasis; Angiogenesis
Public URL
Publisher URL
Additional Information Authors' accepted manuscript of article published in: Coordination chemistry reviews, 2016, v.306, part 1


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Copyright Statement
© 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

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