Principal component analysis of atrial fibrillation: Inclusion of posterior ECG leads does not improve correlation with left atrial activity

Raine, Daniel; Langley, Philip; Shepherd, Ewen; Lord, Stephen; Murray, Stephen; Murray, Alan; Bourke, John P.

Abstract

Background Lead V₁ is routinely analysed due to its large amplitude AF waveform. V₁ correlates strongly with right atrial activity but only moderately with left atrial activity. Posterior lead V₉ correlates strongest with left atrial activity. Aims (1) To establish whether surface dominant AF frequency (DAF) calculated using principal component analysis (PCA) of a modified 12-lead ECG (including posterior leads) has a stronger correlation with left atrial activity compared to the standard ECG. (2) To assess the contribution of individual ECG leads to the AF principal component in both ECG configurations. Methods Patients were assigned to modified or standard ECG groups. In the modified ECG, posterior leads V₈ and V₉ replaced V₄ and V₆. AF waveform was extracted from one-minute surface ECG recordings using PCA. Surface DAF was correlated with intracardiac DAF from the high right atrium (HRA), coronary sinus (CS) and pulmonary veins (PVs). Results 96 patients were studied. Surface DAF from the modified ECG did not have a stronger correlation with left atrial activity compared to the standard ECG. Both ECG configurations correlated strongly with HRA, CS and right PVs but only moderately with left PVs. V₁ contributed most to the AF principal component in both ECG configurations.

Citation

Raine, D., Langley, P., Shepherd, E., Lord, S., Murray, S., Murray, A., & Bourke, J. P. (2015). Principal component analysis of atrial fibrillation: Inclusion of posterior ECG leads does not improve correlation with left atrial activity. Medical engineering & physics, 37(2), 251-255. https://doi.org/10.1016/j.medengphy.2014.12.008

• Journal Article Type: Article
• Acceptance Date: Dec 26, 2014
• Publication Date: Feb 1, 2015
• Deposit Date: Oct 21, 2015
• Publicly Available Date: Nov 23, 2017
• Journal: Medical engineering and physics
• Print ISSN: 1350-4533
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 37
• Issue: 2
• Pages: 251-255
• DOI: https://doi.org/10.1016/j.medengphy.2014.12.008
• Keywords: Surface electrocardiogram; Principal component analysis; QRST subtraction; Dominant frequency; Atrial fibrillation
• Public URL: https://hull-repository.worktribe.com/output/379861
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S1350453315000077
• Additional Information: Copy of article first published in: Medical engineering and physics, 2015, v.37, issue 2.
• Contract Date: Nov 23, 2017