Dr Pedro Beltran-Alvarez P.Beltran-Alvarez@hull.ac.uk
Senior Lecturer in Health and Climate Change and Programme co-Director of the MSc Health and Climate Change
An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels
Beltran-Alvarez, Pedro; Onwuli, Donatus O.
Authors
Donatus O. Onwuli
Abstract
Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials. Voltage-gated sodium channels expression, localisation and function are regulated by a range of transcriptional and post-translational mechanisms. Here, we review our understanding of regulation of brain voltage-gated sodium channels, in particular SCN1A (Naᵥ1.1), SCN2A (Naᵥ1.2), SCN3A (Naᵥ1.3) and SCN8A (Naᵥ1.6), by transcription factors, by alternative splicing, and by post-translational modifications. Our focus is strongly centred on recent research lines, and newly generated knowledge.
Citation
Beltran-Alvarez, P., & Onwuli, D. O. (2016). An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels. Amino acids, 48(3), 641-651. https://doi.org/10.1007/s00726-015-2122-y
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 16, 2015 |
Online Publication Date | Oct 27, 2015 |
Publication Date | Mar 1, 2016 |
Deposit Date | Dec 15, 2015 |
Publicly Available Date | Mar 28, 2024 |
Journal | Amino acids |
Print ISSN | 0939-4451 |
Electronic ISSN | 1438-2199 |
Publisher | Springer Verlag |
Peer Reviewed | Peer Reviewed |
Volume | 48 |
Issue | 3 |
Pages | 641-651 |
DOI | https://doi.org/10.1007/s00726-015-2122-y |
Keywords | Voltage-gated sodium channel; Regulation; Transcription factor; Alternative splicing; Post-translational modification |
Public URL | https://hull-repository.worktribe.com/output/382706 |
Publisher URL | http://link.springer.com/article/10.1007%2Fs00726-015-2122-y |
Additional Information | The final publication is available at Springer via http://dx.doi.org/10.1007/s00726-015-2122-y |
Files
Article.pdf
(780 Kb)
PDF
Copyright Statement
© The Author(s) 2015. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
You might also like
Heat induces multiomic and phenotypic stress propagation in zebrafish embryos
(2023)
Journal Article
Inhibition of arginine methylation impairs platelet function
(2021)
Journal Article
Downloadable Citations
About Repository@Hull
Administrator e-mail: repository@hull.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search