An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels

Beltran-Alvarez, Pedro; Onwuli, Donatus O.

Abstract

Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials. Voltage-gated sodium channels expression, localisation and function are regulated by a range of transcriptional and post-translational mechanisms. Here, we review our understanding of regulation of brain voltage-gated sodium channels, in particular SCN1A (Naᵥ1.1), SCN2A (Naᵥ1.2), SCN3A (Naᵥ1.3) and SCN8A (Naᵥ1.6), by transcription factors, by alternative splicing, and by post-translational modifications. Our focus is strongly centred on recent research lines, and newly generated knowledge.

Citation

Beltran-Alvarez, P., & Onwuli, D. O. (2016). An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels. Amino acids, 48(3), 641-651. https://doi.org/10.1007/s00726-015-2122-y

• Journal Article Type: Article
• Acceptance Date: Oct 16, 2015
• Online Publication Date: Oct 27, 2015
• Publication Date: Mar 1, 2016
• Deposit Date: Dec 15, 2015
• Publicly Available Date: Nov 23, 2017
• Journal: Amino acids
• Print ISSN: 0939-4451
• Electronic ISSN: 1438-2199
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 48
• Issue: 3
• Pages: 641-651
• DOI: https://doi.org/10.1007/s00726-015-2122-y
• Keywords: Voltage-gated sodium channel; Regulation; Transcription factor; Alternative splicing; Post-translational modification
• Public URL: https://hull-repository.worktribe.com/output/382706
• Publisher URL: http://link.springer.com/article/10.1007%2Fs00726-015-2122-y
• Additional Information: The final publication is available at Springer via http://dx.doi.org/10.1007/s00726-015-2122-y