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An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels

Beltran-Alvarez, Pedro; Onwuli, Donatus O.

Authors

Donatus O. Onwuli

Abstract

Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials. Voltage-gated sodium channels expression, localisation and function are regulated by a range of transcriptional and post-translational mechanisms. Here, we review our understanding of regulation of brain voltage-gated sodium channels, in particular SCN1A (Naᵥ1.1), SCN2A (Naᵥ1.2), SCN3A (Naᵥ1.3) and SCN8A (Naᵥ1.6), by transcription factors, by alternative splicing, and by post-translational modifications. Our focus is strongly centred on recent research lines, and newly generated knowledge.

Journal Article Type Article
Publication Date Mar 1, 2016
Journal Amino acids
Print ISSN 0939-4451
Electronic ISSN 1438-2199
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 48
Issue 3
Pages 641-651
Institution Citation Beltran-Alvarez, P., & Onwuli, D. O. (2016). An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels. Amino acids, 48(3), 641-651. https://doi.org/10.1007/s00726-015-2122-y
DOI https://doi.org/10.1007/s00726-015-2122-y
Keywords Voltage-gated sodium channel; Regulation; Transcription factor; Alternative splicing; Post-translational modification
Publisher URL http://link.springer.com/article/10.1007%2Fs00726-015-2122-y
Copyright Statement © The Author(s) 2015. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://​creativecommons.​org/​licenses/​by/​4.​0/​), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Additional Information The final publication is available at Springer via http://dx.doi.org/10.1007/s00726-015-2122-y

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Copyright Statement
© The Author(s) 2015. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://​creativecommons.​org/​licenses/​by/​4.​0/​), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.



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