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An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels

Beltran-Alvarez, Pedro; Onwuli, Donatus O.


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Dr Pedro Beltran-Alvarez
Senior Lecturer in Health and Climate Change and Programme co-Director of the MSc Health and Climate Change

Donatus O. Onwuli


Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials. Voltage-gated sodium channels expression, localisation and function are regulated by a range of transcriptional and post-translational mechanisms. Here, we review our understanding of regulation of brain voltage-gated sodium channels, in particular SCN1A (Naᵥ1.1), SCN2A (Naᵥ1.2), SCN3A (Naᵥ1.3) and SCN8A (Naᵥ1.6), by transcription factors, by alternative splicing, and by post-translational modifications. Our focus is strongly centred on recent research lines, and newly generated knowledge.


Beltran-Alvarez, P., & Onwuli, D. O. (2016). An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels. Amino acids, 48(3), 641-651.

Journal Article Type Article
Acceptance Date Oct 16, 2015
Online Publication Date Oct 27, 2015
Publication Date Mar 1, 2016
Deposit Date Dec 15, 2015
Publicly Available Date Nov 23, 2017
Journal Amino acids
Print ISSN 0939-4451
Electronic ISSN 1438-2199
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 48
Issue 3
Pages 641-651
Keywords Voltage-gated sodium channel; Regulation; Transcription factor; Alternative splicing; Post-translational modification
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Publisher URL
Additional Information The final publication is available at Springer via


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Copyright Statement
© The Author(s) 2015. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://​creativecommons.​org/​licenses/​by/​4.​0/​), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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