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Infection in prosthetic material

Smith, George; Chetter, Ian



Surgical site infection (SSI) occurs when a wound created as part of a surgical procedure becomes infected. SSI is one of the most common healthcare-associated infections and occurs in approximately 5% of patients undergoing a surgical procedure. SSI may lead to patients suffering considerable morbidity or mortality and have significant cost implications. The aetiology involves the interplay of host, environmental and pathogen factors all of which should be addressed in seeking to reduce the risk of developing an infection. The presence of prosthetic material reduces the number of bacteria necessary for an infection to develop and can give rise to treatment and diagnostic difficulties. The responsible organisms are most commonly Staphylococcus aureus and S. epidermidis. Diagnosis is frequently problematic and antibiotic treatment alone is often ineffective due to biofilm formation necessitating removal of prosthesis in many cases. Prevention of infection is by far the most important aspect of prosthetic implant surgery. Patient optimization is equally important as the cutting edge research into biological prostheses in reducing the incidence of prosthetic infection in future practice.


Smith, G., & Chetter, I. (2015). Infection in prosthetic material. Surgery (Oxford), 33(11), 559-564.

Journal Article Type Article
Acceptance Date Jan 1, 2015
Online Publication Date Oct 7, 2015
Publication Date 2015-11
Deposit Date Dec 18, 2015
Publicly Available Date Nov 23, 2017
Journal Surgery
Print ISSN 0263-9319
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 33
Issue 11
Pages 559-564
Keywords Infection; Orthopaedics; Prosthesis; Radiology; Surgery; Vascular
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Publisher URL
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Additional Information Authors' accepted manuscript of article published in: Surgery, 2015, v.33, issue 11.


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