Skip to main content

Research Repository

Advanced Search

Sensing Intra‐ and Extra‐Cellular Ca 2+ in the Islet of Langerhans

Huang, Weikun; Wu, Tongzhi; Xie, Cong; Rayner, Christopher K.; Priest, Craig; Ebendorff‐Heidepriem, Heike; Zhao, Jiangbo (Tim)

Authors

Weikun Huang

Tongzhi Wu

Cong Xie

Christopher K. Rayner

Craig Priest

Heike Ebendorff‐Heidepriem



Abstract

Calcium ions (Ca2+) take part in intra- and inter-cellular signaling to mediate cellular functions. Sensing this ubiquitous messenger is instrumental in disentangling the specific functions of cellular sub-compartments and/or intercellular communications. In this review, the authors first describe intra- and inter-cellular Ca2+ signaling in relation to insulin secretion from the pancreatic islets, and then outline the development of diverse sensors, for example, chemically synthesized indicators, genetically encoded proteins, and ion-selective microelectrodes, for intra- and extra-cellular sensing of Ca2+. Particular emphasis is placed on emerging approaches in this field, such as low-affinity Ca2+ indicators and unique Ca2+-responsive composite materials. The authors conclude by remarking on the challenges and opportunities for further developments in this field, which may facilitate a more comprehensive understanding of Ca2+ signaling within and outside the islets, and its relevance in health and disease.

Citation

Huang, W., Wu, T., Xie, C., Rayner, C. K., Priest, C., Ebendorff‐Heidepriem, H., & Zhao, J. (. (2022). Sensing Intra‐ and Extra‐Cellular Ca 2+ in the Islet of Langerhans. Advanced Functional Materials, 32(3), Article 2106020. https://doi.org/10.1002/adfm.202106020

Journal Article Type Article
Acceptance Date Oct 16, 2021
Online Publication Date Nov 5, 2021
Publication Date Jan 14, 2022
Deposit Date Nov 9, 2021
Publicly Available Date Nov 6, 2022
Journal Advanced Functional Materials
Print ISSN 1616-301X
Electronic ISSN 1616-3028
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 32
Issue 3
Article Number 2106020
DOI https://doi.org/10.1002/adfm.202106020
Keywords Ca 2+ oscillation; Ca 2+ sensors; Ca 2+ signaling; Insulin secretion; Islets of Langerhans
Public URL https://hull-repository.worktribe.com/output/3875517

Files


Accepted manuscript (3.3 Mb)
PDF

Copyright Statement
©2021 The authors. All rights reserved. No part of this publication may be reproduced without the written permission of the copyright holder




You might also like



Downloadable Citations