Sensing Intra‐ and Extra‐Cellular Ca 2+ in the Islet of Langerhans

Huang, Weikun; Wu, Tongzhi; Xie, Cong; Rayner, Christopher K.; Priest, Craig; Ebendorff‐Heidepriem, Heike; Zhao, Jiangbo (Tim)

Abstract

Calcium ions (Ca2+) take part in intra- and inter-cellular signaling to mediate cellular functions. Sensing this ubiquitous messenger is instrumental in disentangling the specific functions of cellular sub-compartments and/or intercellular communications. In this review, the authors first describe intra- and inter-cellular Ca2+ signaling in relation to insulin secretion from the pancreatic islets, and then outline the development of diverse sensors, for example, chemically synthesized indicators, genetically encoded proteins, and ion-selective microelectrodes, for intra- and extra-cellular sensing of Ca2+. Particular emphasis is placed on emerging approaches in this field, such as low-affinity Ca2+ indicators and unique Ca2+-responsive composite materials. The authors conclude by remarking on the challenges and opportunities for further developments in this field, which may facilitate a more comprehensive understanding of Ca2+ signaling within and outside the islets, and its relevance in health and disease.

Citation

Huang, W., Wu, T., Xie, C., Rayner, C. K., Priest, C., Ebendorff‐Heidepriem, H., & Zhao, J. (. (2022). Sensing Intra‐ and Extra‐Cellular Ca 2+ in the Islet of Langerhans. Advanced Functional Materials, 32(3), Article 2106020. https://doi.org/10.1002/adfm.202106020

• Journal Article Type: Article
• Acceptance Date: Oct 16, 2021
• Online Publication Date: Nov 5, 2021
• Publication Date: Jan 14, 2022
• Deposit Date: Nov 9, 2021
• Publicly Available Date: Nov 6, 2022
• Journal: Advanced Functional Materials
• Print ISSN: 1616-301X
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 32
• Issue: 3
• Article Number: 2106020
• DOI: https://doi.org/10.1002/adfm.202106020
• Keywords: Ca 2+ oscillation; Ca 2+ sensors; Ca 2+ signaling; Insulin secretion; Islets of Langerhans
• Public URL: https://hull-repository.worktribe.com/output/3875517